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                  Page - 1 of 1                  Record - 1 of 6   [TOP]
Compound ID3902
Compound Structure
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Plant SourceAllium stipitatum Regel     Common Name:Ornamental Onion, Glory of Pamir
Source FamilyAmaryllidaceae
OriginSpalding, Lincolnshire, UK
Plant Part UsedBulb
ExtractChloroform
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test Done
Positive Control Used (conc.)Ethambutol, Isoniazid
Inhibition [%]90 %
Activity [MIC] µg/ml0.01 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified2 - (Methyldithio) Pyridine - N - Oxide
PubChem IDNR
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19093848
Extract PreparationA 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol
Chemical Classification [Active Compound]Aromatic, Alkaloid, Pyridine-N-Oxide, Disulfide
Media / Broth Used [Antimicrobial Assay/Test]Columbia blood agar (Oxoid)
Cytotoxicity Assay [AID]Sulforhodamine B Short - Term Cytotoxicity Assay
Molecular Weight172.997
Molecular FormulaC6H7NOS2
SMILESC1cc[n+](c(c1)SSC)[O-]
XLogP1.646
PSA77.540
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count2
No. of Rings1
No. of N1
No. of O1
No. of S2
Reference(s)1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

CuratorVikramjitmandal

                  Record - 2 of 6   [TOP]
Compound ID3903
Compound Structure
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Plant SourceAllium stipitatum Regel     Common Name:Ornamental Onion, Glory of Pamir
Source FamilyAmaryllidaceae
OriginSpalding, Lincolnshire, UK
Plant Part UsedBulb
ExtractChloroform
Target BacteriaMycobacterium fortuitum
Assay / Test DoneNR
Positive Control Used (conc.)Ethambutol (2 µg/ml), Isoniazid (0.25 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml8 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified2 - (Methyldithio) Pyridine - N - Oxide
PubChem IDNR
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19093848
Extract PreparationA 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol
Chemical Classification [Active Compound]Aromatic, Alkaloid, Pyridine-N-Oxide, Disulfide
Media / Broth Used [Antimicrobial Assay/Test]Columbia blood agar (Oxoid)
Cytotoxicity Assay [AID]Sulforhodamine B Short - Term Cytotoxicity Assay
Molecular Weight172.997
Molecular FormulaC6H7NOS2
SMILESC1cc[n+](c(c1)SSC)[O-]
XLogP1.646
PSA77.540
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count2
No. of Rings1
No. of N1
No. of O1
No. of S2
Reference(s)1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

CuratorVikramjitmandal

                  Record - 3 of 6   [TOP]
Compound ID3904
Compound Structure
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Plant SourceAllium stipitatum Regel     Common Name:Ornamental Onion, Glory of Pamir
Source FamilyAmaryllidaceae
OriginSpalding, Lincolnshire, UK
Plant Part UsedBulb
ExtractChloroform
Target BacteriaMycobacterium smegmatis
Assay / Test DoneNR
Positive Control Used (conc.)Ethambutol (32 µg/ml), Isoniazid (0.25 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml8 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified2 - (Methyldithio) Pyridine - N - Oxide
PubChem IDNR
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19093848
Extract PreparationA 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol
Chemical Classification [Active Compound]Aromatic, Alkaloid, Pyridine-N-Oxide, Disulfide
Media / Broth Used [Antimicrobial Assay/Test]Columbia blood agar (Oxoid)
Cytotoxicity Assay [AID]Sulforhodamine B Short - Term Cytotoxicity Assay
Molecular Weight172.997
Molecular FormulaC6H7NOS2
SMILESC1cc[n+](c(c1)SSC)[O-]
XLogP1.646
PSA77.540
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count2
No. of Rings1
No. of N1
No. of O1
No. of S2
Reference(s)1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

CuratorVikramjitmandal

                  Record - 4 of 6   [TOP]
Compound ID3905
Compound Structure
DOWNLOAD:
Plant SourceAllium stipitatum Regel     Common Name:Ornamental Onion, Glory of Pamir
Source FamilyAmaryllidaceae
OriginSpalding, Lincolnshire, UK
Plant Part UsedBulb
ExtractChloroform
Target BacteriaMycobacterium smegmatis (mc2 2700)
Assay / Test DoneNR
Positive Control Used (conc.)ND
Inhibition [%]NR
Activity [MIC] µg/ml8 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified2 - (Methyldithio) Pyridine - N - Oxide
PubChem IDNR
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19093848
Extract PreparationA 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol
Chemical Classification [Active Compound]Aromatic, Alkaloid, Pyridine-N-Oxide, Disulfide
Media / Broth Used [Antimicrobial Assay/Test]Columbia blood agar (Oxoid)
Cytotoxicity Assay [AID]Sulforhodamine B Short - Term Cytotoxicity Assay
Molecular Weight172.997
Molecular FormulaC6H7NOS2
SMILESC1cc[n+](c(c1)SSC)[O-]
XLogP1.646
PSA77.540
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count2
No. of Rings1
No. of N1
No. of O1
No. of S2
Reference(s)1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

CuratorVikramjitmandal

                  Record - 5 of 6   [TOP]
Compound ID3906
Compound Structure
DOWNLOAD:
Plant SourceAllium stipitatum Regel     Common Name:Ornamental Onion, Glory of Pamir
Source FamilyAmaryllidaceae
OriginSpalding, Lincolnshire, UK
Plant Part UsedBulb
ExtractChloroform
Target BacteriaMycobacterium phlei
Assay / Test DoneNR
Positive Control Used (conc.)Ethambutol (2 µg/ml), Isoniazid (128 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml2 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified2 - (Methyldithio) Pyridine - N - Oxide
PubChem IDNR
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19093848
Extract PreparationA 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol
Chemical Classification [Active Compound]Aromatic, Alkaloid, Pyridine-N-Oxide, Disulfide
Media / Broth Used [Antimicrobial Assay/Test]Columbia blood agar (Oxoid)
Cytotoxicity Assay [AID]Sulforhodamine B Short - Term Cytotoxicity Assay
Molecular Weight172.997
Molecular FormulaC6H7NOS2
SMILESC1cc[n+](c(c1)SSC)[O-]
XLogP1.646
PSA77.540
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count2
No. of Rings1
No. of N1
No. of O1
No. of S2
Reference(s)1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

CuratorVikramjitmandal

                  Record - 6 of 6   [TOP]
Compound ID3907
Compound Structure
DOWNLOAD:
Plant SourceAllium stipitatum Regel     Common Name:Ornamental Onion, Glory of Pamir
Source FamilyAmaryllidaceae
OriginSpalding, Lincolnshire, UK
Plant Part UsedBulb
ExtractChloroform
Target BacteriaMycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test DoneNR
Positive Control Used (conc.)Ethambutol, Isoniazid
Inhibition [%]90 %
Activity [MIC] µg/ml0.01 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified2 - (Methyldithio) Pyridine - N - Oxide
PubChem IDNR
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19093848
Extract PreparationA 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol
Chemical Classification [Active Compound]Aromatic, Alkaloid, Pyridine-N-Oxide, Disulfide
Media / Broth Used [Antimicrobial Assay/Test]Columbia blood agar (Oxoid)
Cytotoxicity Assay [AID]Sulforhodamine B Short - Term Cytotoxicity Assay
Molecular Weight172.997
Molecular FormulaC6H7NOS2
SMILESC1cc[n+](c(c1)SSC)[O-]
XLogP1.646
PSA77.540
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count2
No. of Rings1
No. of N1
No. of O1
No. of S2
Reference(s)1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

CuratorVikramjitmandal


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