| Compound ID | 1493 |
| Compound Structure |  |
| Plant Source | Clinacanthus siamensis Brem. Common Name:Sophaghni, Vishaghni, Vishalata (Sanskrit) |
| Source Family | Acanthaceae |
| Origin | Thailand |
| Plant Part Used | Fresh leaf |
| Extract | Ethanol |
| Target Bacteria | Mycobacterium tuberculosis H37Ra |
| Assay / Test Done | Microplate Alamar Blue Assay (MABA) |
| Positive Control Used (conc.) | Isoniazid (0.040 - 0.090 µg/ml) and Kanamycin sulphate (2.0 - 5.0 µg/ml) |
| Inhibition [%] | |
| Activity [MIC] µg/ml | 200 µg/ml |
| Activity (In terms of dilution) | |
| Activity (Zone of inhibition in mm) | |
| Active Compound Identified | Trans - 3 - Methylthioacrylamide |
| PubChem ID | 11819072 |
| Ethnomedicinal Information | Poison bites, inflammation, traumatic edema and swelling due to poison stings. |
| PubMed ID [Source Literature] | 14646322 |
| Extract Preparation | N/A |
| Chemical Classification [Active Compound] | Aliphatic, Alkene, Amide, Thioether |
| Media / Broth Used [Antimicrobial Assay/Test] | N/A |
| Cytotoxicity Assay [AID] | N/A |
| Molecular Weight | 117.025 |
| Molecular Formula | C4H7NOS
|
| SMILES | S(/C=C/C(=O)N)C |
| XLogP | 0.313 |
| PSA | 68.390 |
| H-bond Donor | 1 |
| H-bond Acceptor | 3 |
| No. of Rotatable Bond Count | 2 |
| No. of Rings | 0 |
| No. of N | 1 |
| No. of O | 1 |
| No. of S | 1 |
| Reference(s) | 1) Tuntiwachwuttikul P, Pootaeng-on Y, Pansa P, Srisanpang T, Taylor WC.Sulfur-containing compounds from Clinacanthus siamensis.Chem Pharm Bull (Tokyo). 2003 Dec;51(12):1423-5
2) http://ayurvedicmedicinalplants.com/index.php?option=com_zoom&Itemid=26&page=view&catid=3&key=63&hit=1
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| Curator | |
