|  Home  |Search   |  Browse  |Similarity   |Data Visualization  |Submission  |Contact Us  |  













                  Page - 1 of 1                  Record - 1 of 5   [TOP]
Compound ID1687
Compound Structure
DOWNLOAD:
Plant SourceEuclea natalensis A. DC.     Common Name:Natal Guarri, Natal Ebony, Large Leaved Guarri
Source FamilyEbenaceae
OriginAfrica
Plant Part UsedRoot
ExtractEthanol
Target BacteriaMycobacterium smegmatis
Assay / Test DoneModified two - fold serial dilution assay
Positive Control Used (conc.)Isoniazid (2.93 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml57.29 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedShinanolone
PubChem IDNR
Ethnomedicinal InformationRespiratory chest problems, coughs, tuberculosis
PubMed ID [Source Literature]18591787
Extract PreparationPowdered plant material was combined in a 1 : 10 ratio with solvent and shaken vigorously for 30 min using a mechanical shaker before being filtered through Whatman No. 1 filter paper. The solvent was removed in a stream of air and the residues redissolved in DMSO to a concentration of 200 mg/ml
Chemical Classification [Active Compound]Aromatic, Bicyclic, Ketone, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]Middlebrook 7H9 broth supplemented with 10 % OADC medium
Cytotoxicity Assay [AID]N/A
Molecular Weight192.079
Molecular FormulaC11H12O3
SMILESC1(CCC(=O)c2c(cc(cc12)C)O)O
XLogP0.653
PSA57.530
H-bond Donor2
H-bond Acceptor3
No. of Rotatable Bond Count0
No. of Rings2
No. of N0
No. of O3
No. of S0
Reference(s)1) McGaw LJ, Lall N, Hlokwe TM, Michel AL, Meyer JJ, Eloff JN.Purified compounds and extracts from Euclea species with antimycobacterial activity against Mycobacterium bovis and fast-growing mycobacteria.Biol Pharm Bull. 2008 Jul;31(7):1429-33

Curator

                  Record - 2 of 5   [TOP]
Compound ID1691
Compound Structure
DOWNLOAD:
Plant SourceEuclea natalensis A. DC.     Common Name:Natal Guarri, Natal Ebony, Large Leaved Guarri
Source FamilyEbenaceae
OriginAfrica
Plant Part UsedRoot
ExtractEthanol
Target BacteriaMycobacterium fortuitum
Assay / Test DoneModified two - fold serial dilution assay
Positive Control Used (conc.)Isoniazid (1.95 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml125 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedShinanolone
PubChem IDNR
Ethnomedicinal InformationRespiratory chest problems, coughs, tuberculosis
PubMed ID [Source Literature]18591787
Extract PreparationPowdered plant material was combined in a 1 : 10 ratio with solvent and shaken vigorously for 30 min using a mechanical shaker before being filtered through Whatman No. 1 filter paper. The solvent was removed in a stream of air and the residues redissolved in DMSO to a concentration of 200 mg/ml
Chemical Classification [Active Compound]Aromatic, Bicyclic, Ketone, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]Middlebrook 7H9 broth supplemented with 10 % OADC medium
Cytotoxicity Assay [AID]N/A
Molecular Weight192.079
Molecular FormulaC11H12O3
SMILESC1(CCC(=O)c2c(cc(cc12)C)O)O
XLogP0.653
PSA57.530
H-bond Donor2
H-bond Acceptor3
No. of Rotatable Bond Count0
No. of Rings2
No. of N0
No. of O3
No. of S0
Reference(s)1) McGaw LJ, Lall N, Hlokwe TM, Michel AL, Meyer JJ, Eloff JN.Purified compounds and extracts from Euclea species with antimycobacterial activity against Mycobacterium bovis and fast-growing mycobacteria.Biol Pharm Bull. 2008 Jul;31(7):1429-33

Curator

                  Record - 3 of 5   [TOP]
Compound ID1695
Compound Structure
DOWNLOAD:
Plant SourceEuclea natalensis A. DC.     Common Name:Natal Guarri, Natal Ebony, Large Leaved Guarri
Source FamilyEbenaceae
OriginAfrica
Plant Part UsedRoot
ExtractEthanol
Target BacteriaMycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test DoneModified two - fold serial dilution assay
Positive Control Used (conc.)Isoniazid (3.26 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml166.67 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedShinanolone
PubChem IDNR
Ethnomedicinal InformationRespiratory chest problems, coughs, tuberculosis
PubMed ID [Source Literature]18591787
Extract PreparationPowdered plant material was combined in a 1 : 10 ratio with solvent and shaken vigorously for 30 min using a mechanical shaker before being filtered through Whatman No. 1 filter paper. The solvent was removed in a stream of air and the residues redissolved in DMSO to a concentration of 200 mg/ml
Chemical Classification [Active Compound]Aromatic, Bicyclic, Ketone, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]Middlebrook 7H9 broth supplemented with 10 % OADC medium
Cytotoxicity Assay [AID]N/A
Molecular Weight192.079
Molecular FormulaC11H12O3
SMILESC1(CCC(=O)c2c(cc(cc12)C)O)O
XLogP0.653
PSA57.530
H-bond Donor2
H-bond Acceptor3
No. of Rotatable Bond Count0
No. of Rings2
No. of N0
No. of O3
No. of S0
Reference(s)1) McGaw LJ, Lall N, Hlokwe TM, Michel AL, Meyer JJ, Eloff JN.Purified compounds and extracts from Euclea species with antimycobacterial activity against Mycobacterium bovis and fast-growing mycobacteria.Biol Pharm Bull. 2008 Jul;31(7):1429-33

Curator

                  Record - 4 of 5   [TOP]
Compound ID1699
Compound Structure
DOWNLOAD:
Plant SourceEuclea natalensis A. DC.     Common Name:Natal Guarri, Natal Ebony, Large Leaved Guarri
Source FamilyEbenaceae
OriginAfrica
Plant Part UsedRoot
ExtractEthanol
Target BacteriaMycobacterium bovis ATCC
Assay / Test DoneModified two - fold serial dilution assay
Positive Control Used (conc.)Isoniazid (1.49 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml3.74 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedShinanolone
PubChem IDNR
Ethnomedicinal InformationRespiratory chest problems, coughs, tuberculosis
PubMed ID [Source Literature]18591787
Extract PreparationPowdered plant material was combined in a 1 : 10 ratio with solvent and shaken vigorously for 30 min using a mechanical shaker before being filtered through Whatman No. 1 filter paper. The solvent was removed in a stream of air and the residues redissolved in DMSO to a concentration of 200 mg/ml
Chemical Classification [Active Compound]Aromatic, Bicyclic, Ketone, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]Middlebrook 7H9 broth supplemented with 10 % OADC medium
Cytotoxicity Assay [AID]N/A
Molecular Weight192.079
Molecular FormulaC11H12O3
SMILESC1(CCC(=O)c2c(cc(cc12)C)O)O
XLogP0.653
PSA57.530
H-bond Donor2
H-bond Acceptor3
No. of Rotatable Bond Count0
No. of Rings2
No. of N0
No. of O3
No. of S0
Reference(s)1) McGaw LJ, Lall N, Hlokwe TM, Michel AL, Meyer JJ, Eloff JN.Purified compounds and extracts from Euclea species with antimycobacterial activity against Mycobacterium bovis and fast-growing mycobacteria.Biol Pharm Bull. 2008 Jul;31(7):1429-33

Curator

                  Record - 5 of 5   [TOP]
Compound ID1703
Compound Structure
DOWNLOAD:
Plant SourceEuclea natalensis A. DC.     Common Name:Natal Guarri, Natal Ebony, Large Leaved Guarri
Source FamilyEbenaceae
OriginAfrica
Plant Part UsedRoot
ExtractEthanol
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneModified two - fold serial dilution assay
Positive Control Used (conc.)Isoniazid (0.062 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedShinanolone
PubChem IDNR
Ethnomedicinal InformationRespiratory chest problems, coughs, tuberculosis
PubMed ID [Source Literature]18591787
Extract PreparationN/APowdered plant material was combined in a 1 : 10 ratio with solvent and shaken vigorously for 30 min using a mechanical shaker before being filtered through Whatman No. 1 filter paper. The solvent was removed in a stream of air and the residues redissolved in DMSO to a concentration of 200 mg/ml
Chemical Classification [Active Compound]Aromatic, Bicyclic, Ketone, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]Middlebrook 7H9 broth supplemented with 10 % OADC medium
Cytotoxicity Assay [AID]N/A
Molecular Weight192.079
Molecular FormulaC11H12O3
SMILESC1(CCC(=O)c2c(cc(cc12)C)O)O
XLogP0.653
PSA57.530
H-bond Donor2
H-bond Acceptor3
No. of Rotatable Bond Count0
No. of Rings2
No. of N0
No. of O3
No. of S0
Reference(s)1) McGaw LJ, Lall N, Hlokwe TM, Michel AL, Meyer JJ, Eloff JN.Purified compounds and extracts from Euclea species with antimycobacterial activity against Mycobacterium bovis and fast-growing mycobacteria.Biol Pharm Bull. 2008 Jul;31(7):1429-33

Curator


Developed by: CSIR- OSDD Unit, Delhi, India and Hosted by: Bioinformatics Centre,   Institute of Microbial Technology, Sec-39A, Chandigarh, India.
The website has been tested on the latest version of Google Chrome (34.0.1847.137 m) and Mozilla Firefox (29.0.1)