BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 6 [TOP]

Compound ID

3563

Compound Structure

Plant Source

Cryptolepis sanguinolenta Common Name:Nibima

Source Family

Apocynaceae

Origin

West Africa

Plant Part Used

Root

Extract

Ammonia moistened chloroform

Target Bacteria

Mycobacterium fortuitum

Assay / Test Done

MTT Assay

Positive Control Used (conc.)

Ethambutol (8 µg/ml), Isoniazid (0.5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

16 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Cryptolepine hydrochloride

PubChem ID

156093

Ethnomedicinal Information

Antimycobacterial, antimalarial

PubMed ID [Source Literature]

12722159

Extract Preparation

Cryptolepine was isolated from Cryptolepis sanguinolenta roots and crystallized as the hydrochloride salt

Chemical Classification [Active Compound]

Aromatic, Quinoline, Alkaloid, Indole

Media / Broth Used [Antimicrobial Assay/Test]

Mueller - Hinton broth, Colombia blood agar, 7H9 Middle Brook medium

Cytotoxicity Assay [AID]

Molecular Weight

232.100

Molecular Formula

C₁₆H₁₃ClN₂

SMILES

Cl.n1(c2c(nc3c2cccc3)cc2c1cccc2)C

XLogP

4.596

PSA

15.600

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Gibbons S, Fallah F, Wright CW.Cryptolepine hydrochloride: a potent antimycobacterial alkaloid derived from Cryptolepis sanguinolenta.Phytother Res. 2003 Apr;17(4):434-6

Curator

Wvarsha, rachanake

Record - 2 of 6 [TOP]

Compound ID

3564

Compound Structure

Plant Source

Cryptolepis sanguinolenta Common Name:Nibima

Source Family

Apocynaceae

Origin

West Africa

Plant Part Used

Root

Extract

Ammonia moistened chloroform

Target Bacteria

Mycobacterium smegmatis (ATCC 14468)

Assay / Test Done

MTT Assay

Positive Control Used (conc.)

Ethambutol (0.25 µg/ml), Isoniazid (2 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

8 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Cryptolepine hydrochloride

PubChem ID

156093

Ethnomedicinal Information

Antimycobacterial, antimalarial

PubMed ID [Source Literature]

12722159

Extract Preparation

Cryptolepine was isolated from Cryptolepis sanguinolenta roots and crystallized as the hydrochloride salt

Chemical Classification [Active Compound]

Aromatic, Quinoline, Alkaloid, Indole

Media / Broth Used [Antimicrobial Assay/Test]

Mueller - Hinton broth, Colombia blood agar, 7H9 Middle Brook medium

Cytotoxicity Assay [AID]

Molecular Weight

232.100

Molecular Formula

C₁₆H₁₃ClN₂

SMILES

Cl.n1(c2c(nc3c2cccc3)cc2c1cccc2)C

XLogP

4.596

PSA

15.600

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Gibbons S, Fallah F, Wright CW.Cryptolepine hydrochloride: a potent antimycobacterial alkaloid derived from Cryptolepis sanguinolenta.Phytother Res. 2003 Apr;17(4):434-6

Curator

Wvarsha, rachanake

Record - 3 of 6 [TOP]

Compound ID

3565

Compound Structure

Plant Source

Cryptolepis sanguinolenta Common Name:Nibima

Source Family

Apocynaceae

Origin

West Africa

Plant Part Used

Root

Extract

Ammonia moistened chloroform

Target Bacteria

Mycobacterium phlei

Assay / Test Done

MTT Assay

Positive Control Used (conc.)

Ethambutol (1 µg/ml), Isoniazid (2 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

4 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Cryptolepine hydrochloride

PubChem ID

156093

Ethnomedicinal Information

Antimycobacterial, antimalarial

PubMed ID [Source Literature]

12722159

Extract Preparation

Cryptolepine was isolated from Cryptolepis sanguinolenta roots and crystallized as the hydrochloride salt

Chemical Classification [Active Compound]

Aromatic, Quinoline, Alkaloid, Indole

Media / Broth Used [Antimicrobial Assay/Test]

Mueller - Hinton broth, Colombia blood agar, 7H9 Middle Brook medium

Cytotoxicity Assay [AID]

Molecular Weight

232.100

Molecular Formula

C₁₆H₁₃ClN₂

SMILES

Cl.n1(c2c(nc3c2cccc3)cc2c1cccc2)C

XLogP

4.596

PSA

15.600

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Gibbons S, Fallah F, Wright CW.Cryptolepine hydrochloride: a potent antimycobacterial alkaloid derived from Cryptolepis sanguinolenta.Phytother Res. 2003 Apr;17(4):434-6

Curator

Wvarsha, rachanake

Record - 4 of 6 [TOP]

Compound ID

3566

Compound Structure

Plant Source

Cryptolepis sanguinolenta Common Name:Nibima

Source Family

Apocynaceae

Origin

West Africa

Plant Part Used

Root

Extract

Ammonia moistened chloroform

Target Bacteria

Mycobacterium abscessus

Assay / Test Done

MTT Assay

Positive Control Used (conc.)

Ethambutol (128 µg/ml), Isoniazid (32 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

32 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Cryptolepine hydrochloride

PubChem ID

156093

Ethnomedicinal Information

Antimycobacterial, antimalarial

PubMed ID [Source Literature]

12722159

Extract Preparation

Cryptolepine was isolated from Cryptolepis sanguinolenta roots and crystallized as the hydrochloride salt

Chemical Classification [Active Compound]

Aromatic, Quinoline, Alkaloid, Indole

Media / Broth Used [Antimicrobial Assay/Test]

Mueller - Hinton broth, Colombia blood agar, 7H9 Middle Brook medium

Cytotoxicity Assay [AID]

Molecular Weight

232.100

Molecular Formula

C₁₆H₁₃ClN₂

SMILES

Cl.n1(c2c(nc3c2cccc3)cc2c1cccc2)C

XLogP

4.596

PSA

15.600

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Gibbons S, Fallah F, Wright CW.Cryptolepine hydrochloride: a potent antimycobacterial alkaloid derived from Cryptolepis sanguinolenta.Phytother Res. 2003 Apr;17(4):434-6

Curator

Wvarsha, rachanake

Record - 5 of 6 [TOP]

Compound ID

3567

Compound Structure

Plant Source

Cryptolepis sanguinolenta Common Name:Nibima

Source Family

Apocynaceae

Origin

West Africa

Plant Part Used

Root

Extract

Ammonia moistened chloroform

Target Bacteria

Mycobacterium aurum

Assay / Test Done

MTT Assay

Positive Control Used (conc.)

Ethambutol (1 µg/ml), Isoniazid (2 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

2 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Cryptolepine hydrochloride

PubChem ID

156093

Ethnomedicinal Information

Antimycobacterial,AntimalAerial

PubMed ID [Source Literature]

12722159

Extract Preparation

Cryptolepine was isolated from Cryptolepis sanguinolenta roots and crystallized as the hydrochloride salt

Chemical Classification [Active Compound]

Aromatic, Quinoline, Alkaloid, Indole

Media / Broth Used [Antimicrobial Assay/Test]

Mueller - Hinton broth, Colombia blood agar, 7H9 Middle Brook medium

Cytotoxicity Assay [AID]

Molecular Weight

232.100

Molecular Formula

C₁₆H₁₃ClN₂

SMILES

Cl.n1(c2c(nc3c2cccc3)cc2c1cccc2)C

XLogP

4.596

PSA

15.600

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Gibbons S, Fallah F, Wright CW.Cryptolepine hydrochloride: a potent antimycobacterial alkaloid derived from Cryptolepis sanguinolenta.Phytother Res. 2003 Apr;17(4):434-6

Curator

Wvarsha, rachanake

Record - 6 of 6 [TOP]

Compound ID

3568

Compound Structure

Plant Source

Cryptolepis sanguinolenta Common Name:Nibima

Source Family

Apocynaceae

Origin

West Africa

Plant Part Used

Root

Extract

Ammonia moistened chloroform

Target Bacteria

Mycobacterium bovis (BCG - Bacillus Calmette Guerin)

Assay / Test Done

MTT Assay

Positive Control Used (conc.)

Streptomycin sulphate (6.25 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

12.5 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Cryptolepine hydrochloride

PubChem ID

156093

Ethnomedicinal Information

Antimycobacterial,AntimalAerial

PubMed ID [Source Literature]

12722159

Extract Preparation

Cryptolepine was isolated from Cryptolepis sanguinolenta roots and crystallized as the hydrochloride salt

Chemical Classification [Active Compound]

Aromatic, Quinoline, Alkaloid, Indole

Media / Broth Used [Antimicrobial Assay/Test]

Mueller - Hinton broth, Colombia blood agar, 7H9 Middle Brook medium

Cytotoxicity Assay [AID]

Molecular Weight

232.100

Molecular Formula

C₁₆H₁₃ClN₂

SMILES

Cl.n1(c2c(nc3c2cccc3)cc2c1cccc2)C

XLogP

4.596

PSA

15.600

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Gibbons S, Fallah F, Wright CW.Cryptolepine hydrochloride: a potent antimycobacterial alkaloid derived from Cryptolepis sanguinolenta.Phytother Res. 2003 Apr;17(4):434-6

Curator

Wvarsha, rachanake

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