|  Home  |Search   |  Browse  |Similarity   |Data Visualization  |Submission  |Contact Us  |  













                  Page - 1 of 1                  Record - 1 of 5   [TOP]
Compound ID1685
Compound Structure
DOWNLOAD:
Plant SourceEuclea natalensis A. DC.     Common Name:Natal Guarri, Natal Ebony, Large Leaved Guarri
Source FamilyEbenaceae
OriginAfrica
Plant Part UsedRoot
Extract
Target BacteriaMycobacterium smegmatis
Assay / Test DoneModified two - fold serial dilution assay
Positive Control Used (conc.)Isoniazid (2.93 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml4.72 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedNeodiospyrin
PubChem ID   16072922
Ethnomedicinal InformationRespiratory chest problems, coughs, tuberculosis
PubMed ID [Source Literature]18591787
Extract PreparationPowdered plant material was combined in a 1 : 10 ratio with solvent and shaken vigorously for 30 min using a mechanical shaker before being filtered through Whatman No. 1 filter paper. The solvent was removed in a stream of air and the residues redissolved in DMSO to a concentration of 200 mg/ml
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Nathalene, Napthoquinone, Phenol
Media / Broth Used [Antimicrobial Assay/Test]Middlebrook 7H9 broth supplemented with 10 % OADC medium
Cytotoxicity Assay [AID]N/A
Molecular Weight374.079
Molecular FormulaC22H14O6
SMILESOc1c2c(c(C3=CC(=O)c4c(C3=O)c(O)cc(c4)C)c(c1)C)C(=O)C=CC2=O
XLogP1.294
PSA108.740
H-bond Donor2
H-bond Acceptor6
No. of Rotatable Bond Count1
No. of Rings4
No. of N0
No. of O6
No. of S0
Reference(s)1) McGaw LJ, Lall N, Hlokwe TM, Michel AL, Meyer JJ, Eloff JN.Purified compounds and extracts from Euclea species with antimycobacterial activity against Mycobacterium bovis and fast-growing mycobacteria.Biol Pharm Bull. 2008 Jul;31(7):1429-33

Curator

                  Record - 2 of 5   [TOP]
Compound ID1689
Compound Structure
DOWNLOAD:
Plant SourceEuclea natalensis A. DC.     Common Name:Natal Guarri, Natal Ebony, Large Leaved Guarri
Source FamilyEbenaceae
OriginAfrica
Plant Part UsedRoot
Extract
Target BacteriaMycobacterium fortuitum
Assay / Test DoneModified two - fold serial dilution assay
Positive Control Used (conc.)Isoniazid (1.95 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml93.75 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedNeodiospyrin
PubChem ID   16072922
Ethnomedicinal InformationRespiratory chest problems, coughs, tuberculosis
PubMed ID [Source Literature]18591787
Extract PreparationPowdered plant material was combined in a 1 : 10 ratio with solvent and shaken vigorously for 30 min using a mechanical shaker before being filtered through Whatman No. 1 filter paper. The solvent was removed in a stream of air and the residues redissolved in DMSO to a concentration of 200 mg/ml
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Nathalene, Napthoquinone, Phenol
Media / Broth Used [Antimicrobial Assay/Test]Middlebrook 7H9 broth supplemented with 10 % OADC medium
Cytotoxicity Assay [AID]N/A
Molecular Weight374.079
Molecular FormulaC22H14O6
SMILESOc1c2c(c(C3=CC(=O)c4c(C3=O)c(O)cc(c4)C)c(c1)C)C(=O)C=CC2=O
XLogP1.294
PSA108.740
H-bond Donor2
H-bond Acceptor6
No. of Rotatable Bond Count1
No. of Rings4
No. of N0
No. of O6
No. of S0
Reference(s)1) McGaw LJ, Lall N, Hlokwe TM, Michel AL, Meyer JJ, Eloff JN.Purified compounds and extracts from Euclea species with antimycobacterial activity against Mycobacterium bovis and fast-growing mycobacteria.Biol Pharm Bull. 2008 Jul;31(7):1429-33

Curator

                  Record - 3 of 5   [TOP]
Compound ID1693
Compound Structure
DOWNLOAD:
Plant SourceEuclea natalensis A. DC.     Common Name:Natal Guarri, Natal Ebony, Large Leaved Guarri
Source FamilyEbenaceae
OriginAfrica
Plant Part UsedRoot
Extract
Target BacteriaMycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test DoneModified two - fold serial dilution assay
Positive Control Used (conc.)Isoniazid (3.26 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml98.96 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedNeodiospyrin
PubChem ID   16072922
Ethnomedicinal InformationRespiratory chest problems, coughs, tuberculosis
PubMed ID [Source Literature]18591787
Extract PreparationPowdered plant material was combined in a 1 : 10 ratio with solvent and shaken vigorously for 30 min using a mechanical shaker before being filtered through Whatman No. 1 filter paper. The solvent was removed in a stream of air and the residues redissolved in DMSO to a concentration of 200 mg/ml
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Nathalene, Napthoquinone, Phenol
Media / Broth Used [Antimicrobial Assay/Test]Middlebrook 7H9 broth supplemented with 10 % OADC medium
Cytotoxicity Assay [AID]N/A
Molecular Weight374.079
Molecular FormulaC22H14O6
SMILESOc1c2c(c(C3=CC(=O)c4c(C3=O)c(O)cc(c4)C)c(c1)C)C(=O)C=CC2=O
XLogP1.294
PSA108.740
H-bond Donor2
H-bond Acceptor6
No. of Rotatable Bond Count1
No. of Rings4
No. of N0
No. of O6
No. of S0
Reference(s)1) McGaw LJ, Lall N, Hlokwe TM, Michel AL, Meyer JJ, Eloff JN.Purified compounds and extracts from Euclea species with antimycobacterial activity against Mycobacterium bovis and fast-growing mycobacteria.Biol Pharm Bull. 2008 Jul;31(7):1429-33

Curator

                  Record - 4 of 5   [TOP]
Compound ID1697
Compound Structure
DOWNLOAD:
Plant SourceEuclea natalensis A. DC.     Common Name:Natal Guarri, Natal Ebony, Large Leaved Guarri
Source FamilyEbenaceae
OriginAfrica
Plant Part UsedRoot
Extract
Target BacteriaMycobacterium bovis ATCC
Assay / Test DoneModified two - fold serial dilution assay
Positive Control Used (conc.)Isoniazid (1.49 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml17.58 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedNeodiospyrin
PubChem ID   16072922
Ethnomedicinal InformationRespiratory chest problems, coughs, tuberculosis
PubMed ID [Source Literature]18591787
Extract PreparationPowdered plant material was combined in a 1 : 10 ratio with solvent and shaken vigorously for 30 min using a mechanical shaker before being filtered through Whatman No. 1 filter paper. The solvent was removed in a stream of air and the residues redissolved in DMSO to a concentration of 200 mg/ml
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Nathalene, Napthoquinone, Phenol
Media / Broth Used [Antimicrobial Assay/Test]Middlebrook 7H9 broth supplemented with 10 % OADC medium
Cytotoxicity Assay [AID]N/A
Molecular Weight374.079
Molecular FormulaC22H14O6
SMILESOc1c2c(c(C3=CC(=O)c4c(C3=O)c(O)cc(c4)C)c(c1)C)C(=O)C=CC2=O
XLogP1.294
PSA108.740
H-bond Donor2
H-bond Acceptor6
No. of Rotatable Bond Count1
No. of Rings4
No. of N0
No. of O6
No. of S0
Reference(s)1) McGaw LJ, Lall N, Hlokwe TM, Michel AL, Meyer JJ, Eloff JN.Purified compounds and extracts from Euclea species with antimycobacterial activity against Mycobacterium bovis and fast-growing mycobacteria.Biol Pharm Bull. 2008 Jul;31(7):1429-33

Curator

                  Record - 5 of 5   [TOP]
Compound ID1701
Compound Structure
DOWNLOAD:
Plant SourceEuclea natalensis A. DC.     Common Name:Natal Guarri, Natal Ebony, Large Leaved Guarri
Source FamilyEbenaceae
OriginAfrica
Plant Part UsedRoot
Extract
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneModified two - fold serial dilution assay
Positive Control Used (conc.)Isoniazid (0.062 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml10 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedNeodiospyrin
PubChem ID   16072922
Ethnomedicinal InformationRespiratory chest problems, coughs, tuberculosis
PubMed ID [Source Literature]18591787
Extract PreparationPowdered plant material was combined in a 1 : 10 ratio with solvent and shaken vigorously for 30 min using a mechanical shaker before being filtered through Whatman No. 1 filter paper. The solvent was removed in a stream of air and the residues redissolved in DMSO to a concentration of 200 mg/ml
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Nathalene, Napthoquinone, Phenol
Media / Broth Used [Antimicrobial Assay/Test]Middlebrook 7H9 broth supplemented with 10 % OADC medium
Cytotoxicity Assay [AID]N/A
Molecular Weight374.079
Molecular FormulaC22H14O6
SMILESOc1c2c(c(C3=CC(=O)c4c(C3=O)c(O)cc(c4)C)c(c1)C)C(=O)C=CC2=O
XLogP1.294
PSA108.740
H-bond Donor2
H-bond Acceptor6
No. of Rotatable Bond Count1
No. of Rings4
No. of N0
No. of O6
No. of S0
Reference(s)1) McGaw LJ, Lall N, Hlokwe TM, Michel AL, Meyer JJ, Eloff JN.Purified compounds and extracts from Euclea species with antimycobacterial activity against Mycobacterium bovis and fast-growing mycobacteria.Biol Pharm Bull. 2008 Jul;31(7):1429-33

Curator


Developed by: CSIR- OSDD Unit, Delhi, India and Hosted by: Bioinformatics Centre,   Institute of Microbial Technology, Sec-39A, Chandigarh, India.
The website has been tested on the latest version of Google Chrome (34.0.1847.137 m) and Mozilla Firefox (29.0.1)