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                  Page - 1 of 1                  Record - 1 of 4   [TOP]
Compound ID1412
Compound Structure
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Plant SourceCephaelis dichroa     Common Name:
Source FamilyRubiaceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Isoniazid (0.06 µg/ml), Ethambutol (2 µg/ml), Rifampin (0.06 µg/ml), Streptomycin (0.50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml> 50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedStrictosidine
PubChem ID   161336
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tricyclic, Alkaloid, Indole, Pyran, Ester, Sugar
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight530.226
Molecular FormulaC27H34N2O9
SMILESO([C@@H]1OC=C([C@@H](C[C@@H]2NCCc3c2[nH]c2c3cccc2)[C@H]1C=C)C(=O)OC)[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)CO
XLogP1.559
PSA162.730
H-bond Donor6
H-bond Acceptor11
No. of Rotatable Bond Count8
No. of Rings5
No. of N2
No. of O9
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

Curator

                  Record - 2 of 4   [TOP]
Compound ID1414
Compound Structure
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Plant SourceCephaelis dichroa     Common Name:
Source FamilyRubiaceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis (345)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (3.125 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedStrictosidine
PubChem ID   161336
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tricyclic, Alkaloid, Indole, Pyran, Ester, Sugar
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight530.226
Molecular FormulaC27H34N2O9
SMILESO([C@@H]1OC=C([C@@H](C[C@@H]2NCCc3c2[nH]c2c3cccc2)[C@H]1C=C)C(=O)OC)[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)CO
XLogP1.559
PSA162.730
H-bond Donor6
H-bond Acceptor11
No. of Rotatable Bond Count8
No. of Rings5
No. of N2
No. of O9
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

Curator

                  Record - 3 of 4   [TOP]
Compound ID1416
Compound Structure
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Plant SourceCephaelis dichroa     Common Name:
Source FamilyRubiaceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis (M12)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (12.50 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml> 200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedStrictosidine
PubChem ID   161336
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tricyclic, Alkaloid, Indole, Pyran, Ester, Sugar
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight530.226
Molecular FormulaC27H34N2O9
SMILESO([C@@H]1OC=C([C@@H](C[C@@H]2NCCc3c2[nH]c2c3cccc2)[C@H]1C=C)C(=O)OC)[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)CO
XLogP1.559
PSA162.730
H-bond Donor6
H-bond Acceptor11
No. of Rotatable Bond Count8
No. of Rings5
No. of N2
No. of O9
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

Curator

                  Record - 4 of 4   [TOP]
Compound ID1418
Compound Structure
DOWNLOAD:
Plant SourceCephaelis dichroa     Common Name:
Source FamilyRubiaceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis (M20)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (25 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedStrictosidine
PubChem ID   161336
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tricyclic, Alkaloid, Indole, Pyran, Ester, Sugar
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight530.226
Molecular FormulaC27H34N2O9
SMILESO([C@@H]1OC=C([C@@H](C[C@@H]2NCCc3c2[nH]c2c3cccc2)[C@H]1C=C)C(=O)OC)[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)CO
XLogP1.559
PSA162.730
H-bond Donor6
H-bond Acceptor11
No. of Rotatable Bond Count8
No. of Rings5
No. of N2
No. of O9
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

Curator


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