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                  Page - 1 of 1                  Record - 1 of 4   [TOP]
Compound ID1876
Compound Structure
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Plant SourceHydrastis canadensis     Common Name:Goldenseal
Source FamilyRanunculaceae
OriginNorth America
Plant Part UsedRoot
ExtractEthanol
Target BacteriaMycobacterium smegmatis (ATCC 607)
Assay / Test Done
Positive Control Used (conc.)Streptomycin sulfate (1.56 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml25 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedBerberine
PubChem ID   2353
Ethnomedicinal InformationBerberine has been demonstrated to reduce the infectivity of bacteria, fungi and protozoa in animals and humans by inhibiting the adherence of microorganisms to the host cells
PubMed ID [Source Literature]9784149, 4906191
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Isoquinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight336.124
Molecular FormulaC20H18NO4
SMILESO1c2cc3CC[n+]4c(c3cc2OC1)cc1c(c4)c(OC)c(OC)cc1
XLogP2.896
PSA40.800
H-bond Donor0
H-bond Acceptor4
No. of Rotatable Bond Count2
No. of Rings5
No. of N1
No. of O4
No. of S0
Reference(s)1) Gentry EJ, Jampani HB, Keshavarz-Shokri A, Morton MD, Velde DV, Telikepalli H, Mitscher LA, Shawar R, Humble D, Baker W.Antitubercular natural products: berberine from the roots of commercial Hydrastis canadensis powder. Isolation of inactive 8-oxotetrahydrothalifendine, canadine, beta-hydrastine, and two new quinic acid esters, hycandinic acid esters-1 and -2.J Nat Prod. 1998 Oct;61(10):1187-93

2) Amin AH, Subbaiah TV, Abbasi KM.Berberine sulfate: antimicrobial activity, bioassay, and mode of action.Can J Microbiol. 1969 Sep;15(9):1067-76

Curator

                  Record - 2 of 4   [TOP]
Compound ID1877
Compound Structure
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Plant SourceHydrastis canadensis     Common Name:Goldenseal
Source FamilyRanunculaceae
OriginNorth America
Plant Part UsedRoot
ExtractEthanol
Target BacteriaMycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test Done
Positive Control Used (conc.)NR
Inhibition [%]
Activity [MIC] µg/ml200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedBerberine
PubChem ID   2353
Ethnomedicinal InformationBerberine has been demonstrated to reduce the infectivity of bacteria, fungi and protozoa in animals and humans by inhibiting the adherence of microorganisms to the host cells
PubMed ID [Source Literature]9784149, 4906191
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Isoquinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight336.124
Molecular FormulaC20H18NO4
SMILESO1c2cc3CC[n+]4c(c3cc2OC1)cc1c(c4)c(OC)c(OC)cc1
XLogP2.896
PSA40.800
H-bond Donor0
H-bond Acceptor4
No. of Rotatable Bond Count2
No. of Rings5
No. of N1
No. of O4
No. of S0
Reference(s)1) Gentry EJ, Jampani HB, Keshavarz-Shokri A, Morton MD, Velde DV, Telikepalli H, Mitscher LA, Shawar R, Humble D, Baker W.Antitubercular natural products: berberine from the roots of commercial Hydrastis canadensis powder. Isolation of inactive 8-oxotetrahydrothalifendine, canadine, beta-hydrastine, and two new quinic acid esters, hycandinic acid esters-1 and -2.J Nat Prod. 1998 Oct;61(10):1187-93

2) Amin AH, Subbaiah TV, Abbasi KM.Berberine sulfate: antimicrobial activity, bioassay, and mode of action.Can J Microbiol. 1969 Sep;15(9):1067-76

Curator

                  Record - 3 of 4   [TOP]
Compound ID1878
Compound Structure
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Plant SourceHydrastis canadensis     Common Name:Goldenseal
Source FamilyRanunculaceae
OriginNorth America
Plant Part UsedRoot
ExtractEthanol
Target BacteriaMycobacterium avium complex
Assay / Test Done
Positive Control Used (conc.)Streptomycin sulfate (6.25 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedBerberine
PubChem ID   2353
Ethnomedicinal InformationBerberine has been demonstrated to reduce the infectivity of bacteria, fungi and protozoa in animals and humans by inhibiting the adherence of microorganisms to the host cells
PubMed ID [Source Literature]9784149, 4906191
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Isoquinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight336.124
Molecular FormulaC20H18NO4
SMILESO1c2cc3CC[n+]4c(c3cc2OC1)cc1c(c4)c(OC)c(OC)cc1
XLogP2.896
PSA40.800
H-bond Donor0
H-bond Acceptor4
No. of Rotatable Bond Count2
No. of Rings5
No. of N1
No. of O4
No. of S0
Reference(s)1) Gentry EJ, Jampani HB, Keshavarz-Shokri A, Morton MD, Velde DV, Telikepalli H, Mitscher LA, Shawar R, Humble D, Baker W.Antitubercular natural products: berberine from the roots of commercial Hydrastis canadensis powder. Isolation of inactive 8-oxotetrahydrothalifendine, canadine, beta-hydrastine, and two new quinic acid esters, hycandinic acid esters-1 and -2.J Nat Prod. 1998 Oct;61(10):1187-93

2) Amin AH, Subbaiah TV, Abbasi KM.Berberine sulfate: antimicrobial activity, bioassay, and mode of action.Can J Microbiol. 1969 Sep;15(9):1067-76

Curator

                  Record - 4 of 4   [TOP]
Compound ID3395
Compound Structure
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Plant SourceHydrastis canadensis     Common Name:
Source FamilyRanunculaceae
OriginNorth America
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneAgar Dilution - Streak Assay
Positive Control Used (conc.)NR
Inhibition [%]
Activity [MIC] µg/ml25 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedBerberine
PubChem ID   2353
Ethnomedicinal InformationNR
PubMed ID [Source Literature]9828037
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Isoquinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]NR
Molecular Weight336.124
Molecular FormulaC20H18NO4
SMILESO1c2cc3CC[n+]4c(c3cc2OC1)cc1c(c4)c(OC)c(OC)cc1
XLogP2.896
PSA40.800
H-bond Donor0
H-bond Acceptor4
No. of Rotatable Bond Count2
No. of Rings5
No. of N1
No. of O4
No. of S0
Reference(s)1) Mitscher LA, Baker W.Tuberculosis: a search for novel therapy starting with natural products.Med Res Rev. 1998 Nov;18(6):363-74

CuratorWvarsha, keyamukherjee, rachanake


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