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                  Page - 1 of 1                  Record - 1 of 5   [TOP]
Compound ID1686
Compound Structure
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Plant SourceEuclea natalensis A. DC.     Common Name:Natal Guarri, Natal Ebony, Large Leaved Guarri
Source FamilyEbenaceae
OriginAfrica
Plant Part UsedRoot
ExtractAcetone
Target BacteriaMycobacterium smegmatis
Assay / Test DoneModified two - fold serial dilution assay
Positive Control Used (conc.)Isoniazid (2.93 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml1.57 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified7 - Methyljuglone
PubChem ID   26905
Ethnomedicinal InformationRespiratory chest problems, coughs, tuberculosis
PubMed ID [Source Literature]18591787
Extract PreparationPowdered plant material was combined in a 1 : 10 ratio with solvent and shaken vigorously for 30 min using a mechanical shaker before being filtered through Whatman No. 1 filter paper. The solvent was removed in a stream of air and the residues redissolved in DMSO to a concentration of 200 mg/ml
Chemical Classification [Active Compound]Aromatic, Bicyclic, Napthalene, Quinone, Phenol
Media / Broth Used [Antimicrobial Assay/Test]Middlebrook 7H9 broth supplemented with 10 % OADC medium
Cytotoxicity Assay [AID]N/A
Molecular Weight188.047
Molecular FormulaC11H8O3
SMILESOc1c2c(cc(c1)C)C(=O)C=CC2=O
XLogP0.898
PSA54.370
H-bond Donor1
H-bond Acceptor3
No. of Rotatable Bond Count0
No. of Rings2
No. of N0
No. of O3
No. of S0
Reference(s)1) McGaw LJ, Lall N, Hlokwe TM, Michel AL, Meyer JJ, Eloff JN.Purified compounds and extracts from Euclea species with antimycobacterial activity against Mycobacterium bovis and fast-growing mycobacteria.Biol Pharm Bull. 2008 Jul;31(7):1429-33

Curator

                  Record - 2 of 5   [TOP]
Compound ID1690
Compound Structure
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Plant SourceEuclea natalensis A. DC.     Common Name:Natal Guarri, Natal Ebony, Large Leaved Guarri
Source FamilyEbenaceae
OriginAfrica
Plant Part UsedRoot
ExtractAcetone
Target BacteriaMycobacterium fortuitum
Assay / Test DoneModified two - fold serial dilution assay
Positive Control Used (conc.)Isoniazid (1.95 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml22.14 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified7 - Methyljuglone
PubChem ID   26905
Ethnomedicinal InformationRespiratory chest problems, coughs, tuberculosis
PubMed ID [Source Literature]18591787
Extract PreparationPowdered plant material was combined in a 1 : 10 ratio with solvent and shaken vigorously for 30 min using a mechanical shaker before being filtered through Whatman No. 1 filter paper. The solvent was removed in a stream of air and the residues redissolved in DMSO to a concentration of 200 mg/ml
Chemical Classification [Active Compound]Aromatic, Bicyclic, Napthalene, Quinone, Phenol
Media / Broth Used [Antimicrobial Assay/Test]Middlebrook 7H9 broth supplemented with 10 % OADC medium
Cytotoxicity Assay [AID]N/A
Molecular Weight188.047
Molecular FormulaC11H8O3
SMILESOc1c2c(cc(c1)C)C(=O)C=CC2=O
XLogP0.898
PSA54.370
H-bond Donor1
H-bond Acceptor3
No. of Rotatable Bond Count0
No. of Rings2
No. of N0
No. of O3
No. of S0
Reference(s)1) McGaw LJ, Lall N, Hlokwe TM, Michel AL, Meyer JJ, Eloff JN.Purified compounds and extracts from Euclea species with antimycobacterial activity against Mycobacterium bovis and fast-growing mycobacteria.Biol Pharm Bull. 2008 Jul;31(7):1429-33

Curator

                  Record - 3 of 5   [TOP]
Compound ID1694
Compound Structure
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Plant SourceEuclea natalensis A. DC.     Common Name:Natal Guarri, Natal Ebony, Large Leaved Guarri
Source FamilyEbenaceae
OriginAfrica
Plant Part UsedRoot
ExtractAcetone
Target BacteriaMycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test DoneModified two - fold serial dilution assay
Positive Control Used (conc.)Isoniazid (3.26 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml11.78 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified7 - Methyljuglone
PubChem ID   26905
Ethnomedicinal InformationRespiratory chest problems, coughs, tuberculosis
PubMed ID [Source Literature]18591787
Extract PreparationPowdered plant material was combined in a 1 : 10 ratio with solvent and shaken vigorously for 30 min using a mechanical shaker before being filtered through Whatman No. 1 filter paper. The solvent was removed in a stream of air and the residues redissolved in DMSO to a concentration of 200 mg/ml
Chemical Classification [Active Compound]Aromatic, Bicyclic, Napthalene, Quinone, Phenol
Media / Broth Used [Antimicrobial Assay/Test]Middlebrook 7H9 broth supplemented with 10 % OADC medium
Cytotoxicity Assay [AID]N/A
Molecular Weight188.047
Molecular FormulaC11H8O3
SMILESOc1c2c(cc(c1)C)C(=O)C=CC2=O
XLogP0.898
PSA54.370
H-bond Donor1
H-bond Acceptor3
No. of Rotatable Bond Count0
No. of Rings2
No. of N0
No. of O3
No. of S0
Reference(s)1) McGaw LJ, Lall N, Hlokwe TM, Michel AL, Meyer JJ, Eloff JN.Purified compounds and extracts from Euclea species with antimycobacterial activity against Mycobacterium bovis and fast-growing mycobacteria.Biol Pharm Bull. 2008 Jul;31(7):1429-33

Curator

                  Record - 4 of 5   [TOP]
Compound ID1698
Compound Structure
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Plant SourceEuclea natalensis A. DC.     Common Name:Natal Guarri, Natal Ebony, Large Leaved Guarri
Source FamilyEbenaceae
OriginAfrica
Plant Part UsedRoot
ExtractAcetone
Target BacteriaMycobacterium bovis ATCC
Assay / Test DoneModified two - fold serial dilution assay
Positive Control Used (conc.)Isoniazid (1.49 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml1.55 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified7 - Methyljuglone
PubChem ID   26905
Ethnomedicinal InformationRespiratory chest problems, coughs, tuberculosis
PubMed ID [Source Literature]18591787
Extract PreparationPowdered plant material was combined in a 1 : 10 ratio with solvent and shaken vigorously for 30 min using a mechanical shaker before being filtered through Whatman No. 1 filter paper. The solvent was removed in a stream of air and the residues redissolved in DMSO to a concentration of 200 mg/ml
Chemical Classification [Active Compound]Aromatic, Bicyclic, Napthalene, Quinone, Phenol
Media / Broth Used [Antimicrobial Assay/Test]Middlebrook 7H9 broth supplemented with 10 % OADC medium
Cytotoxicity Assay [AID]N/A
Molecular Weight188.047
Molecular FormulaC11H8O3
SMILESOc1c2c(cc(c1)C)C(=O)C=CC2=O
XLogP0.898
PSA54.370
H-bond Donor1
H-bond Acceptor3
No. of Rotatable Bond Count0
No. of Rings2
No. of N0
No. of O3
No. of S0
Reference(s)1) McGaw LJ, Lall N, Hlokwe TM, Michel AL, Meyer JJ, Eloff JN.Purified compounds and extracts from Euclea species with antimycobacterial activity against Mycobacterium bovis and fast-growing mycobacteria.Biol Pharm Bull. 2008 Jul;31(7):1429-33

Curator

                  Record - 5 of 5   [TOP]
Compound ID1702
Compound Structure
DOWNLOAD:
Plant SourceEuclea natalensis A. DC.     Common Name:Natal Guarri, Natal Ebony, Large Leaved Guarri
Source FamilyEbenaceae
OriginAfrica
Plant Part UsedRoot
ExtractAcetone
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneModified two - fold serial dilution assay
Positive Control Used (conc.)Isoniazid (0.062 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml0.5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified7 - Methyljuglone
PubChem ID   26905
Ethnomedicinal InformationRespiratory chest problems, coughs, tuberculosis
PubMed ID [Source Literature]18591787
Extract PreparationPowdered plant material was combined in a 1 : 10 ratio with solvent and shaken vigorously for 30 min using a mechanical shaker before being filtered through Whatman No. 1 filter paper. The solvent was removed in a stream of air and the residues redissolved in DMSO to a concentration of 200 mg/ml
Chemical Classification [Active Compound]Aromatic, Bicyclic, Napthalene, Quinone, Phenol
Media / Broth Used [Antimicrobial Assay/Test]Middlebrook 7H9 broth supplemented with 10 % OADC medium
Cytotoxicity Assay [AID]N/A
Molecular Weight188.047
Molecular FormulaC11H8O3
SMILESOc1c2c(cc(c1)C)C(=O)C=CC2=O
XLogP0.898
PSA54.370
H-bond Donor1
H-bond Acceptor3
No. of Rotatable Bond Count0
No. of Rings2
No. of N0
No. of O3
No. of S0
Reference(s)1) McGaw LJ, Lall N, Hlokwe TM, Michel AL, Meyer JJ, Eloff JN.Purified compounds and extracts from Euclea species with antimycobacterial activity against Mycobacterium bovis and fast-growing mycobacteria.Biol Pharm Bull. 2008 Jul;31(7):1429-33

Curator


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