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Compound ID2554
Compound Structure
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Plant SourceSanguinaria canadensis Linn.     Common Name:Bloodroot
Source FamilyPapaveraceae
OriginNorth America
Plant Part UsedRoot
Extract
Target BacteriaMycobacterium aurum
Assay / Test DoneBroth Microdilution Method (BMM)
Positive Control Used (conc.)Streptomycin (1.14 ± 0.02 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml7.30 ± 1.91 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedChelerythrine
PubChem ID   2703
Ethnomedicinal InformationExpectorant, antimicrobial, antiviral, dentrifice, has anaesthetic properties, used to treat skin infections, pulmonary consumption, fever and epithelial tumours, cough
PubMed ID [Source Literature]11744296
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Quinoline,Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight348.124
Molecular FormulaC21H18NO4
SMILESO1c2cc3c4[n+](cc5c(c4ccc3cc2OC1)ccc(OC)c5OC)C
XLogP3.370
PSA40.800
H-bond Donor0
H-bond Acceptor4
No. of Rotatable Bond Count2
No. of Rings5
No. of N1
No. of O4
No. of S0
Reference(s)1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67

Curator

                  Record - 2 of 3   [TOP]
Compound ID2555
Compound Structure
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Plant SourceSanguinaria canadensis Linn.     Common Name:Bloodroot
Source FamilyPapaveraceae
OriginNorth America
Plant Part UsedRoot
Extract
Target BacteriaMycobacterium smegmatis
Assay / Test DoneBroth Microdilution Method (BMM)
Positive Control Used (conc.)Streptomycin (0.17 ± 0.04 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml29.00 ± 17.60 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedChelerythrine
PubChem ID   2703
Ethnomedicinal InformationExpectorant, antimicrobial, antiviral, dentrifice, has anaesthetic properties, used to treat skin infections, pulmonary consumption, fever and epithelial tumours, cough
PubMed ID [Source Literature]11744296
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Quinoline,Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight348.124
Molecular FormulaC21H18NO4
SMILESO1c2cc3c4[n+](cc5c(c4ccc3cc2OC1)ccc(OC)c5OC)C
XLogP3.370
PSA40.800
H-bond Donor0
H-bond Acceptor4
No. of Rotatable Bond Count2
No. of Rings5
No. of N1
No. of O4
No. of S0
Reference(s)1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67

Curator

                  Record - 3 of 3   [TOP]
Compound ID2556
Compound Structure
DOWNLOAD:
Plant SourceSanguinaria canadensis Linn.     Common Name:Bloodroot
Source FamilyPapaveraceae
OriginNorth America
Plant Part UsedRoot
Extract
Target BacteriaMycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test DoneBroth Microdilution Method (BMM)
Positive Control Used (conc.)Streptomycin (0.17 ± 0.04 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml14.3 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedChelerythrine
PubChem ID   2703
Ethnomedicinal InformationExpectorant, antimicrobial, antiviral, dentrifice, has anaesthetic properties, used to treat skin infections, pulmonary consumption, fever and epithelial tumours, cough
PubMed ID [Source Literature]11744296
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Quinoline,Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight348.124
Molecular FormulaC21H18NO4
SMILESO1c2cc3c4[n+](cc5c(c4ccc3cc2OC1)ccc(OC)c5OC)C
XLogP3.370
PSA40.800
H-bond Donor0
H-bond Acceptor4
No. of Rotatable Bond Count2
No. of Rings5
No. of N1
No. of O4
No. of S0
Reference(s)1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67

Curator


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