| Compound ID | 3634 |
| Compound Structure |  |
| Plant Source | Piper sanctum (Miq.) Schl. Common Name: |
| Source Family | Piperaceae |
| Origin | Southcentral region of Mexico |
| Plant Part Used | Stem |
| Extract | Dichloromethane:Methanol (1:1) |
| Target Bacteria | Mycobacterium tuberculosis H37Rv |
| Assay / Test Done | Microplate Alamar Blue Assay (MABA) |
| Positive Control Used (conc.) | Rifampin (0.25 µg/ml) |
| Inhibition [%] | |
| Activity [MIC] µg/ml | 8 µg/ml |
| Activity (In terms of dilution) | |
| Activity (Zone of inhibition in mm) | |
| Active Compound Identified | Piperolactam A |
| PubChem ID | 3081016 |
| Ethnomedicinal Information | |
| PubMed ID [Source Literature] | 15620234 |
| Extract Preparation | Leaves (1 kg) and stems (2.95 kg) of Piper sanctum were separately air - dried, ground and extracted by maceration with a mixture of CH2Cl2 - MeOH, 1:1 (12 l x 5, respectively), at room temperature. The extracts were concentrated in vacuo to yield 162.4 and 95 g of dry residues, respectively |
| Chemical Classification [Active Compound] | Aromatic, Tetracyclic, Alkaloid, Phenanthrene, Amide, Ether, Phenol |
| Media / Broth Used [Antimicrobial Assay/Test] | |
| Cytotoxicity Assay [AID] | |
| Molecular Weight | 265.074 |
| Molecular Formula | C16H11NO3 |
| SMILES | O(c1c(O)c2c3c([nH]c(=O)c3c1)cc1c2cccc1)C |
| XLogP | 2.860 |
| PSA | 58.560 |
| H-bond Donor | 2 |
| H-bond Acceptor | 4 |
| No. of Rotatable Bond Count | 1 |
| No. of Rings | 4 |
| No. of N | 1 |
| No. of O | 3 |
| No. of S | 0 |
| Reference(s) | 1) Mata R, Morales I, Pérez O, Rivero-Cruz I, Acevedo L, Enriquez-Mendoza I, Bye R, Franzblau S, Timmermann B.Antimycobacterial compounds from Piper sanctum.J Nat Prod. 2004 Dec;67(12):1961-8
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| Curator | Rachana, Keyamukherjee, vikramjitmandal |
