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                  Page - 1 of 1                  Record - 1 of 6   [TOP]
Compound ID3914
Compound Structure
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Plant SourceAllium stipitatum Regel     Common Name:Ornamental Onion, Glory of Pamir
Source FamilyAmaryllidaceae
OriginSpalding, Lincolnshire, UK
Plant Part UsedBulb
ExtractNR
Target BacteriaMycobacterium tuberculosis H37Rv (ATCC 27 294)
Assay / Test DoneNR
Positive Control Used (conc.)
Inhibition [%]NR
Activity [MIC] µg/mlNR
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified2, 2' - Dithio - Bis - Pyridine - N - Oxide (Dipyrithione)
PubChem ID   3109
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19093848
Extract PreparationA 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol
Chemical Classification [Active Compound]Aromatic, Alkaloid, Disulfide, Dipyrithione
Media / Broth Used [Antimicrobial Assay/Test]Columbia blood agar (Oxoid)
Cytotoxicity Assay [AID]Sulforhodamine B Short - Term Cytotoxicity Assay
Molecular Weight252.003
Molecular FormulaC10H8N2O2S2
SMILESS(Sc1[n+]([O-])cccc1)c1[n+]([O-])cccc1
XLogP1.726
PSA104.480
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count3
No. of Rings2
No. of N2
No. of O2
No. of S2
Reference(s)1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

CuratorVikramjitmandal

                  Record - 2 of 6   [TOP]
Compound ID3915
Compound Structure
DOWNLOAD:
Plant SourceAllium stipitatum Regel     Common Name:Ornamental Onion, Glory of Pamir
Source FamilyAmaryllidaceae
OriginSpalding, Lincolnshire, UK
Plant Part UsedBulb
ExtractNR
Target BacteriaMycobacterium fortuitum
Assay / Test DoneNR
Positive Control Used (conc.)Ethambutol (2 µg/ml), Isoniazid (0.25 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml16 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified2, 2' - Dithio - Bis - Pyridine - N - Oxide (Dipyrithione)
PubChem ID   3109
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19093848
Extract PreparationA 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol
Chemical Classification [Active Compound]Aromatic, Alkaloid, Disulfide, Dipyrithione
Media / Broth Used [Antimicrobial Assay/Test]Columbia blood agar (Oxoid)
Cytotoxicity Assay [AID]Sulforhodamine B Short - Term Cytotoxicity Assay
Molecular Weight252.003
Molecular FormulaC10H8N2O2S2
SMILESS(Sc1[n+]([O-])cccc1)c1[n+]([O-])cccc1
XLogP1.726
PSA104.480
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count3
No. of Rings2
No. of N2
No. of O2
No. of S2
Reference(s)1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

CuratorVikramjitmandal

                  Record - 3 of 6   [TOP]
Compound ID3916
Compound Structure
DOWNLOAD:
Plant SourceAllium stipitatum Regel     Common Name:Ornamental Onion, Glory of Pamir
Source FamilyAmaryllidaceae
OriginSpalding, Lincolnshire, UK
Plant Part UsedBulb
ExtractNR
Target BacteriaMycobacterium smegmatis
Assay / Test DoneNR
Positive Control Used (conc.)Ethambutol (32 µg/ml), Isoniazid (0.25 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml16 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified2, 2' - Dithio - Bis - Pyridine - N - Oxide (Dipyrithione)
PubChem ID   3109
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19093848
Extract PreparationA 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol
Chemical Classification [Active Compound]Aromatic, Alkaloid, Disulfide, Dipyrithione
Media / Broth Used [Antimicrobial Assay/Test]Columbia blood agar (Oxoid)
Cytotoxicity Assay [AID]Sulforhodamine B Short - Term Cytotoxicity Assay
Molecular Weight252.003
Molecular FormulaC10H8N2O2S2
SMILESS(Sc1[n+]([O-])cccc1)c1[n+]([O-])cccc1
XLogP1.726
PSA104.480
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count3
No. of Rings2
No. of N2
No. of O2
No. of S2
Reference(s)1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

CuratorVikramjitmandal

                  Record - 4 of 6   [TOP]
Compound ID3917
Compound Structure
DOWNLOAD:
Plant SourceAllium stipitatum Regel     Common Name:Ornamental Onion, Glory of Pamir
Source FamilyAmaryllidaceae
OriginSpalding, Lincolnshire, UK
Plant Part UsedBulb
ExtractNR
Target BacteriaMycobacterium smegmatis (mc2 2700)
Assay / Test DoneNR
Positive Control Used (conc.)Not Tested
Inhibition [%]NR
Activity [MIC] µg/mlNot tested
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified2, 2' - Dithio - Bis - Pyridine - N - Oxide (Dipyrithione)
PubChem ID   3109
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19093848
Extract PreparationA 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol
Chemical Classification [Active Compound]Aromatic, Alkaloid, Disulfide, Dipyrithione
Media / Broth Used [Antimicrobial Assay/Test]Columbia blood agar (Oxoid)
Cytotoxicity Assay [AID]Sulforhodamine B Short - Term Cytotoxicity Assay
Molecular Weight252.003
Molecular FormulaC10H8N2O2S2
SMILESS(Sc1[n+]([O-])cccc1)c1[n+]([O-])cccc1
XLogP1.726
PSA104.480
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count3
No. of Rings2
No. of N2
No. of O2
No. of S2
Reference(s)1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

CuratorVikramjitmandal

                  Record - 5 of 6   [TOP]
Compound ID3918
Compound Structure
DOWNLOAD:
Plant SourceAllium stipitatum Regel     Common Name:Ornamental Onion, Glory of Pamir
Source FamilyAmaryllidaceae
OriginSpalding, Lincolnshire, UK
Plant Part UsedBulb
ExtractNR
Target BacteriaMycobacterium phlei
Assay / Test DoneNR
Positive Control Used (conc.)Ethambutol (2 µg/ml), Isoniazid (128 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml16 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified2, 2' - Dithio - Bis - Pyridine - N - Oxide (Dipyrithione)
PubChem ID   3109
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19093848
Extract PreparationA 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol
Chemical Classification [Active Compound]Aromatic, Alkaloid, Disulfide, Dipyrithione
Media / Broth Used [Antimicrobial Assay/Test]Columbia blood agar (Oxoid)
Cytotoxicity Assay [AID]Sulforhodamine B Short - Term Cytotoxicity Assay
Molecular Weight252.003
Molecular FormulaC10H8N2O2S2
SMILESS(Sc1[n+]([O-])cccc1)c1[n+]([O-])cccc1
XLogP1.726
PSA104.480
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count3
No. of Rings2
No. of N2
No. of O2
No. of S2
Reference(s)1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

CuratorVikramjitmandal

                  Record - 6 of 6   [TOP]
Compound ID3919
Compound Structure
DOWNLOAD:
Plant SourceAllium stipitatum Regel     Common Name:Ornamental Onion, Glory of Pamir
Source FamilyAmaryllidaceae
OriginSpalding, Lincolnshire, UK
Plant Part UsedBulb
ExtractNR
Target BacteriaMycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test DoneNR
Positive Control Used (conc.)
Inhibition [%]NR
Activity [MIC] µg/mlNR
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified2, 2' - Dithio - Bis - Pyridine - N - Oxide (Dipyrithione)
PubChem ID   3109
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19093848
Extract PreparationNR
Chemical Classification [Active Compound]Aromatic, Alkaloid, Disulfide, Dipyrithione
Media / Broth Used [Antimicrobial Assay/Test]Columbia blood agar (Oxoid)
Cytotoxicity Assay [AID]Sulforhodamine B Short - Term Cytotoxicity Assay
Molecular Weight252.003
Molecular FormulaC10H8N2O2S2
SMILESS(Sc1[n+]([O-])cccc1)c1[n+]([O-])cccc1
XLogP1.726
PSA104.480
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count3
No. of Rings2
No. of N2
No. of O2
No. of S2
Reference(s)1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

CuratorVikramjitmandal


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