| Compound ID | 3361 |
| Compound Structure |  |
| Plant Source | Amyris elemifera Common Name:NR |
| Source Family | Rutaceae |
| Origin | Guadeloupe |
| Plant Part Used | NR |
| Extract | NR |
| Target Bacteria | Mycobacterium tuberculosis H37Rv |
| Assay / Test Done | NR |
| Positive Control Used (conc.) | NR |
| Inhibition [%] | NR |
| Activity [MIC] µg/ml | Bactec: 100 µg/ml, 7H11 agar: 200 µg/ml |
| Activity (In terms of dilution) | |
| Activity (Zone of inhibition in mm) | NR |
| Active Compound Identified | Heraclenol |
| PubChem ID | 328236 |
| Ethnomedicinal Information | Antimycobacterial |
| PubMed ID [Source Literature] | 9626931 |
| Extract Preparation | The dried powdered material was moistened with 25 % NH4OH, and extracted by chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH4OH, and extracted with chloroform. The organic phase was washed with water, and dried over Na2SO4. The organic extracts were evaporated and subjected to chromatography on silica gel |
| Chemical Classification [Active Compound] | Aromatic, Tricyclic, Coumarin, Benzofuranoid, Alcohol |
| Media / Broth Used [Antimicrobial Assay/Test] | Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium |
| Cytotoxicity Assay [AID] | NR |
| Molecular Weight | 304.095 |
| Molecular Formula | C16H16O6 |
| SMILES | O(CC(O)C(O)(C)C)c1c2occc2cc2c1oc(=O)cc2 |
| XLogP | 1.710 |
| PSA | 79.900 |
| H-bond Donor | 2 |
| H-bond Acceptor | 5 |
| No. of Rotatable Bond Count | 4 |
| No. of Rings | 3 |
| No. of N | 0 |
| No. of O | 6 |
| No. of S | 0 |
| Reference(s) | 1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73
|
| Curator | Wvarsha, rachanake |
| Compound ID | 3362 |
| Compound Structure | |
| Plant Source | Amyris elemifera Common Name:NR |
| Source Family | Rutaceae |
| Origin | Guadeloupe |
| Plant Part Used | NR |
| Extract | NR |
| Target Bacteria | Mycobacterium avium 733 |
| Assay / Test Done | NR |
| Positive Control Used (conc.) | NR |
| Inhibition [%] | NR |
| Activity [MIC] µg/ml | Bactec: 100 µg/ml, 7H11 agar: 200 µg/ml |
| Activity (In terms of dilution) | NR |
| Activity (Zone of inhibition in mm) | NR |
| Active Compound Identified | Heraclenol |
| PubChem ID | 328236 |
| Ethnomedicinal Information | Antimycobacterial |
| PubMed ID [Source Literature] | 9626931 |
| Extract Preparation | The dried powdered material was moistened with 25 % NH4OH, and extracted by chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH4OH, and extracted with chloroform. The organic phase was washed with water, and dried over Na2SO4. The organic extracts were evaporated and subjected to chromatography on silica gel |
| Chemical Classification [Active Compound] | Aromatic, Tricyclic, Coumarin, Benzofuranoid, Alcohol |
| Media / Broth Used [Antimicrobial Assay/Test] | Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium |
| Cytotoxicity Assay [AID] | NR |
| Molecular Weight | 304.095 |
| Molecular Formula | C16H16O6 |
| SMILES | O(CC(O)C(O)(C)C)c1c2occc2cc2c1oc(=O)cc2 |
| XLogP | 1.710 |
| PSA | 79.900 |
| H-bond Donor | 2 |
| H-bond Acceptor | 5 |
| No. of Rotatable Bond Count | 4 |
| No. of Rings | 3 |
| No. of N | 0 |
| No. of O | 6 |
| No. of S | 0 |
| Reference(s) | 1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73
|
| Curator | Wvarsha, rachanake |
| Compound ID | 3363 |
| Compound Structure | |
| Plant Source | Amyris elemifera Common Name:NR |
| Source Family | Rutaceae |
| Origin | Guadeloupe |
| Plant Part Used | NR |
| Extract | NR |
| Target Bacteria | Mycobacterium kansasii (Clinical isolate 94 - 069) |
| Assay / Test Done | NR |
| Positive Control Used (conc.) | NR |
| Inhibition [%] | NR |
| Activity [MIC] µg/ml | Bactec: > 100 µg/ml, 7H11 agar: 200 µg/ml |
| Activity (In terms of dilution) | NR |
| Activity (Zone of inhibition in mm) | NR |
| Active Compound Identified | Heraclenol |
| PubChem ID | 328236 |
| Ethnomedicinal Information | Antimycobacterial |
| PubMed ID [Source Literature] | 9626931 |
| Extract Preparation | The dried powdered material was moistened with 25 % NH4OH, and extracted by chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH4OH, and extracted with chloroform. The organic phase was washed with water, and dried over Na2SO4. The organic extracts were evaporated and subjected to chromatography on silica gel |
| Chemical Classification [Active Compound] | Aromatic, Tricyclic, Coumarin, Benzofuranoid, Alcohol |
| Media / Broth Used [Antimicrobial Assay/Test] | Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium |
| Cytotoxicity Assay [AID] | NR |
| Molecular Weight | 304.095 |
| Molecular Formula | C16H16O6 |
| SMILES | O(CC(O)C(O)(C)C)c1c2occc2cc2c1oc(=O)cc2 |
| XLogP | 1.710 |
| PSA | 79.900 |
| H-bond Donor | 2 |
| H-bond Acceptor | 5 |
| No. of Rotatable Bond Count | 4 |
| No. of Rings | 3 |
| No. of N | 0 |
| No. of O | 6 |
| No. of S | 0 |
| Reference(s) | 1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73
|
| Curator | Wvarsha, rachanake |
