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                  Page - 1 of 1                  Record - 1 of 6   [TOP]
Compound ID3908
Compound Structure
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Plant SourceAllium stipitatum Regel     Common Name:Ornamental Onion, Glory of Pamir
Source FamilyAmaryllidaceae
OriginSpalding, Lincolnshire, UK
Plant Part UsedBulb
ExtractChloroform
Target BacteriaMycobacterium tuberculosis H37Rv (ATCC 27 294)
Assay / Test DoneNR
Positive Control Used (conc.)Ethambutol, Isoniazid
Inhibition [%]100 %
Activity [MIC] µg/ml0.01 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified2 - [(Methylthiomethyl) Dithio] Pyridine - N - Oxide
PubChem ID   45267926
Ethnomedicinal InformationPromotion of wound healing
PubMed ID [Source Literature]19093848
Extract PreparationA 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol
Chemical Classification [Active Compound]Aromatic, Dithiol, Pyridine-N-Oxide
Media / Broth Used [Antimicrobial Assay/Test]Columbia blood agar (Oxoid)
Cytotoxicity Assay [AID]Sulforhodamine B Short - Term Cytotoxicity Assay
Molecular Weight218.985
Molecular FormulaC7H9NOS3
SMILESS(SCSC)c1[n+]([O-])cccc1
XLogP2.259
PSA102.840
H-bond Donor0
H-bond Acceptor3
No. of Rotatable Bond Count4
No. of Rings1
No. of N1
No. of O1
No. of S3
Reference(s)1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

CuratorVikramjitmandal

                  Record - 2 of 6   [TOP]
Compound ID3909
Compound Structure
DOWNLOAD:
Plant SourceAllium stipitatum Regel     Common Name:Ornamental Onion, Glory of Pamir
Source FamilyAmaryllidaceae
OriginSpalding, Lincolnshire, UK
Plant Part UsedBulb
ExtractChloroform
Target BacteriaMycobacterium fortuitum
Assay / Test DoneNR
Positive Control Used (conc.)Ethambutol (2 µg/ml), Isoniazid (0.25 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml8 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified2 - [(Methylthiomethyl) Dithio] Pyridine - N - Oxide
PubChem ID   45267926
Ethnomedicinal InformationPromotion of wound healing
PubMed ID [Source Literature]19093848
Extract PreparationA 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol
Chemical Classification [Active Compound]Aromatic, Dithiol, Pyridine-N-Oxide
Media / Broth Used [Antimicrobial Assay/Test]Columbia blood agar (Oxoid)
Cytotoxicity Assay [AID]Sulforhodamine B Short - Term Cytotoxicity Assay
Molecular Weight218.985
Molecular FormulaC7H9NOS3
SMILESS(SCSC)c1[n+]([O-])cccc1
XLogP2.259
PSA102.840
H-bond Donor0
H-bond Acceptor3
No. of Rotatable Bond Count4
No. of Rings1
No. of N1
No. of O1
No. of S3
Reference(s)1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

CuratorVikramjitmandal

                  Record - 3 of 6   [TOP]
Compound ID3910
Compound Structure
DOWNLOAD:
Plant SourceAllium stipitatum Regel     Common Name:Ornamental Onion, Glory of Pamir
Source FamilyAmaryllidaceae
OriginSpalding, Lincolnshire, UK
Plant Part UsedBulb
ExtractChloroform
Target BacteriaMycobacterium smegmatis
Assay / Test DoneNR
Positive Control Used (conc.)Ethambutol (32 µg/ml), Isoniazid (0.25 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml4 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified2 - [(Methylthiomethyl) Dithio] Pyridine - N - Oxide
PubChem ID   45267926
Ethnomedicinal InformationPromotion of wound healing
PubMed ID [Source Literature]19093848
Extract PreparationA 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol
Chemical Classification [Active Compound]Aromatic, Dithiol, Pyridine-N-Oxide
Media / Broth Used [Antimicrobial Assay/Test]Columbia blood agar (Oxoid)
Cytotoxicity Assay [AID]Sulforhodamine B Short - Term Cytotoxicity Assay
Molecular Weight218.985
Molecular FormulaC7H9NOS3
SMILESS(SCSC)c1[n+]([O-])cccc1
XLogP2.259
PSA102.840
H-bond Donor0
H-bond Acceptor3
No. of Rotatable Bond Count4
No. of Rings1
No. of N1
No. of O1
No. of S3
Reference(s)1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

CuratorVikramjitmandal

                  Record - 4 of 6   [TOP]
Compound ID3911
Compound Structure
DOWNLOAD:
Plant SourceAllium stipitatum Regel     Common Name:Ornamental Onion, Glory of Pamir
Source FamilyAmaryllidaceae
OriginSpalding, Lincolnshire, UK
Plant Part UsedBulb
ExtractChloroform
Target BacteriaMycobacterium smegmatis (mc2 2700)
Assay / Test DoneNR
Positive Control Used (conc.)Not Tested
Inhibition [%]NR
Activity [MIC] µg/ml4 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified2 - [(Methylthiomethyl) Dithio] Pyridine - N - Oxide
PubChem ID   45267926
Ethnomedicinal InformationPromotion of wound healing
PubMed ID [Source Literature]19093848
Extract PreparationA 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol
Chemical Classification [Active Compound]Aromatic, Dithiol, Pyridine-N-Oxide
Media / Broth Used [Antimicrobial Assay/Test]Columbia blood agar (Oxoid)
Cytotoxicity Assay [AID]Sulforhodamine B Short - Term Cytotoxicity Assay
Molecular Weight218.985
Molecular FormulaC7H9NOS3
SMILESS(SCSC)c1[n+]([O-])cccc1
XLogP2.259
PSA102.840
H-bond Donor0
H-bond Acceptor3
No. of Rotatable Bond Count4
No. of Rings1
No. of N1
No. of O1
No. of S3
Reference(s)1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

CuratorVikramjitmandal

                  Record - 5 of 6   [TOP]
Compound ID3912
Compound Structure
DOWNLOAD:
Plant SourceAllium stipitatum Regel     Common Name:Ornamental Onion, Glory of Pamir
Source FamilyAmaryllidaceae
OriginSpalding, Lincolnshire, UK
Plant Part UsedBulb
ExtractChloroform
Target BacteriaMycobacterium phlei
Assay / Test DoneNR
Positive Control Used (conc.)Ethambutol (2 µg/ml), Isoniazid (128 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml2 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified2 - [(Methylthiomethyl) Dithio] Pyridine - N - Oxide
PubChem ID   45267926
Ethnomedicinal InformationPromotion of wound healing
PubMed ID [Source Literature]19093848
Extract PreparationA 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol
Chemical Classification [Active Compound]Aromatic, Dithiol, Pyridine-N-Oxide
Media / Broth Used [Antimicrobial Assay/Test]Columbia blood agar (Oxoid)
Cytotoxicity Assay [AID]Sulforhodamine B Short - Term Cytotoxicity Assay
Molecular Weight218.985
Molecular FormulaC7H9NOS3
SMILESS(SCSC)c1[n+]([O-])cccc1
XLogP2.259
PSA102.840
H-bond Donor0
H-bond Acceptor3
No. of Rotatable Bond Count4
No. of Rings1
No. of N1
No. of O1
No. of S3
Reference(s)1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

CuratorVikramjitmandal

                  Record - 6 of 6   [TOP]
Compound ID3913
Compound Structure
DOWNLOAD:
Plant SourceAllium stipitatum Regel     Common Name:Ornamental Onion, Glory of Pamir
Source FamilyAmaryllidaceae
OriginSpalding, Lincolnshire, UK
Plant Part UsedBulb
ExtractChloroform
Target BacteriaMycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test DoneNR
Positive Control Used (conc.)Ethambutol, Isoniazid
Inhibition [%]90 %
Activity [MIC] µg/ml0.01 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified2 - [(Methylthiomethyl) Dithio] Pyridine - N - Oxide
PubChem ID   45267926
Ethnomedicinal InformationPromotion of wound healing
PubMed ID [Source Literature]19093848
Extract PreparationA 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol
Chemical Classification [Active Compound]Aromatic, Dithiol, Pyridine-N-Oxide
Media / Broth Used [Antimicrobial Assay/Test]Columbia blood agar (Oxoid)
Cytotoxicity Assay [AID]Sulforhodamine B Short - Term Cytotoxicity Assay
Molecular Weight218.985
Molecular FormulaC7H9NOS3
SMILESS(SCSC)c1[n+]([O-])cccc1
XLogP2.259
PSA102.840
H-bond Donor0
H-bond Acceptor3
No. of Rotatable Bond Count4
No. of Rings1
No. of N1
No. of O1
No. of S3
Reference(s)1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

CuratorVikramjitmandal


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