| Compound ID | 2537 |
| Compound Structure |  |
| Plant Source | Salvia multicaulis Vahl Common Name: |
| Source Family | Lamiaceae |
| Origin | Turkey |
| Plant Part Used | Root |
| Extract | Acetone |
| Target Bacteria | Mycobacterium tuberculosis H37Ra |
| Assay / Test Done | Micro Broth Dilution Method |
| Positive Control Used (conc.) | Rifampin (0.0047 – 0.0095 µg/ml), Isoniazid (0.05 – 0.1 µg/ml), Kanamycin (2.5 – 5.0 µg/ml) |
| Inhibition [%] | |
| Activity [MIC] µg/ml | 5.6 µg/ml |
| Activity (In terms of dilution) | |
| Activity (Zone of inhibition in mm) | |
| Active Compound Identified | Multicaulin |
| PubChem ID | 467782 |
| Ethnomedicinal Information | Used in traditional medicine and have been associated with antibacterial, antituberculous and antiphlogistic activities |
| PubMed ID [Source Literature] | 9428161 |
| Extract Preparation | The powdered roots of S. multicaulis (940 g) were extracted with acetone in a Soxhlet apparatus. The extract was evaporated in vacuo to give 23 g of a residue. The residue was fractionated by column chromatography on a silica gel column, eluted with petroleum ether, followed by a gradient of EtOAc up to 100% and then with EtOH. After TLC analysis, the combined fractions were purified by vacuum-liquid chromatography (VLC), eluting with petroleum ether and ethyl acetate |
| Chemical Classification [Active Compound] | Aromatic, Tricyclic, Phenanthrene, Ether |
| Media / Broth Used [Antimicrobial Assay/Test] | N/A |
| Cytotoxicity Assay [AID] | N/A |
| Molecular Weight | 278.167 |
| Molecular Formula | C20H22O
|
| SMILES | O(c1c(C(C)C)cc2c(c3c(c(c(cc3)C)C)cc2)c1)C |
| XLogP | 8.150 |
| PSA | 9.230 |
| H-bond Donor | 0 |
| H-bond Acceptor | 1 |
| No. of Rotatable Bond Count | 2 |
| No. of Rings | 3 |
| No. of N | 0 |
| No. of O | 1 |
| No. of S | 0 |
| Reference(s) | 1) Ulubelen A, Topcu G, Johansson CB.Norditerpenoids and diterpenoids from Salvia multicaulis with antituberculous activity.J Nat Prod. 1997 Dec;60(12):1275-80
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| Curator | |
