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Compound ID3385
Compound Structure
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Plant SourceTriphasia trifolia     Common Name:NR
Source FamilyRutaceae
OriginGuadeloupe
Plant Part UsedNR
ExtractChloroform
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneNR
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/mlBactec: 100 µg/ml, 7H11 agar: 200 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedIsomeranzin
PubChem ID   473252
Ethnomedicinal InformationAntimycobacterial
PubMed ID [Source Literature]9626931
Extract PreparationThe dried powdered material was moistened with 25 % NH4OH, and extracted by chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH4OH, and extracted with chloroform. The organic phase was washed with water, and dried over Na2SO4. The organic extracts were evaporated and subjected to chromatography on silica gel
Chemical Classification [Active Compound]Aromatic, Bicyclic, Coumarin, Ketone, Ether
Media / Broth Used [Antimicrobial Assay/Test]Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium
Cytotoxicity Assay [AID]NR
Molecular Weight260.105
Molecular FormulaC15H16O4
SMILESO1c2c(CC(=O)C(C)C)c(OC)ccc2ccc1=O
XLogP2.615
PSA43.370
H-bond Donor0
H-bond Acceptor3
No. of Rotatable Bond Count4
No. of Rings2
No. of N0
No. of O4
No. of S0
Reference(s)1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73

CuratorWvarsha, rachanake

                  Record - 2 of 3   [TOP]
Compound ID3386
Compound Structure
DOWNLOAD:
Plant SourceTriphasia trifolia     Common Name:NR
Source FamilyRutaceae
OriginGuadeloupe
Plant Part UsedNR
ExtractChloroform
Target BacteriaMycobacterium avium 733
Assay / Test DoneNR
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/mlBactec: > 100 µg/ml, 7H11 agar: > 200 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedIsomeranzin
PubChem ID   473252
Ethnomedicinal InformationAntimycobacterial
PubMed ID [Source Literature]9626931
Extract PreparationThe dried powdered material was moistened with 25 % NH4OH, and extracted by chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH4OH, and extracted with chloroform. The organic phase was washed with water, and dried over Na2SO4. The organic extracts were evaporated and subjected to chromatography on silica gel
Chemical Classification [Active Compound]Aromatic, Bicyclic, Coumarin, Ketone, Ether
Media / Broth Used [Antimicrobial Assay/Test]Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium
Cytotoxicity Assay [AID]NR
Molecular Weight260.105
Molecular FormulaC15H16O4
SMILESO1c2c(CC(=O)C(C)C)c(OC)ccc2ccc1=O
XLogP2.615
PSA43.370
H-bond Donor0
H-bond Acceptor3
No. of Rotatable Bond Count4
No. of Rings2
No. of N0
No. of O4
No. of S0
Reference(s)1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73

CuratorWvarsha, rachanake

                  Record - 3 of 3   [TOP]
Compound ID3387
Compound Structure
DOWNLOAD:
Plant SourceTriphasia trifolia     Common Name:NR
Source FamilyRutaceae
OriginGuadeloupe
Plant Part UsedNR
ExtractChloroform
Target BacteriaMycobacterium kansasii (Clinical isolate 94 - 069)
Assay / Test DoneNR
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/mlBactec: > 100 µg/ml, 7H11 agar: > 200 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedIsomeranzin
PubChem ID   473252
Ethnomedicinal InformationAntimycobacterial
PubMed ID [Source Literature]9626931
Extract PreparationThe dried powdered material was moistened with 25 % NH4OH, and extracted by chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH4OH, and extracted with chloroform. The organic phase was washed with water, and dried over Na2SO4. The organic extracts were evaporated and subjected to chromatography on silica gel
Chemical Classification [Active Compound]Aromatic, Bicyclic, Coumarin, Ketone, Ether
Media / Broth Used [Antimicrobial Assay/Test]Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium
Cytotoxicity Assay [AID]NR
Molecular Weight260.105
Molecular FormulaC15H16O4
SMILESO1c2c(CC(=O)C(C)C)c(OC)ccc2ccc1=O
XLogP2.615
PSA43.370
H-bond Donor0
H-bond Acceptor3
No. of Rotatable Bond Count4
No. of Rings2
No. of N0
No. of O4
No. of S0
Reference(s)1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73

CuratorWvarsha, rachanake


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