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Compound ID2949
Compound Structure
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Plant SourceHaloxylon salicornicum Bunge ex Boiss     Common Name:NR
Source FamilyChenopodiaceae
OriginPakistan, Egypt, Jordan, Palestine, Iran, Iraq and Kuwait (in unfertile areas)
Plant Part UsedWhole plant
ExtractNR
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMicro Broth Dilution Method
Positive Control Used (conc.)Isoniazid (0.02 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml100 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified1'-Hydroxytetracosanyl cyclohexane
PubChem ID   49797775
Ethnomedicinal InformationNR
PubMed ID [Source Literature]20542692
Extract PreparationMethanol extract further partitioned with water and hexane. The water layer was further extracted with chloroform and subjected to silica gel column chromatography
Chemical Classification [Active Compound]Alkanol, Alicyclic
Media / Broth Used [Antimicrobial Assay/Test]Middlebrook 7H9 broth
Cytotoxicity Assay [AID]NR
Molecular Weight408.433
Molecular FormulaC28H56O
SMILESOCCCCCCCCCCCCCCCCCCCCCCC1CCCCC1
XLogP14.106
PSA20.230
H-bond Donor1
H-bond Acceptor1
No. of Rotatable Bond Count22
No. of Rings1
No. of N0
No. of O1
No. of S0
Reference(s)1) Bibi N, Tanoli SA, Farheen S, Afza N, Siddiqi S, Zhang Y, Kazmi SU, Malik A.In vitro antituberculosis activities of the constituents isolated from Haloxylon salicornicum.Bioorg Med Chem Lett. 2010 Jul 15;20(14):4173-6

CuratorKeyaMukherjee, vsheeba


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