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                  Page - 1 of 1                  Record - 1 of 3   [TOP]
Compound ID2029
Compound Structure
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Plant SourceLeucas volkensii Gurke     Common Name:
Source FamilyLabiatae
OriginKenya
Plant Part UsedAerial
ExtractMethanol
Target BacteriaMycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml2 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified(E)-Phytol
PubChem ID   5280435
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]9491760
Extract PreparationN/A
Chemical Classification [Active Compound]Aliphatic, Alkene, Terpene, Diterpene, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight296.308
Molecular FormulaC20H40O
SMILESOC/C=C(/CCC[C@@H](CCC[C@@H](CCCC(C)C)C)C)C
XLogP8.949
PSA20.230
H-bond Donor1
H-bond Acceptor1
No. of Rotatable Bond Count13
No. of Rings0
No. of N0
No. of O1
No. of S0
Reference(s)1) Rajab MS, Cantrell CL, Franzblau SG, Fischer NH.Antimycobacterial activity of (E)-phytol and derivatives: a preliminary structure-activity study.Planta Med. 1998 Feb;64(1):2-4

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                  Record - 2 of 3   [TOP]
Compound ID2203
Compound Structure
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Plant SourceMorinda citrifolia L.     Common Name:Indian Mulberry (English), Ashyuka, Akshi, Atchy (Sanskrit)
Source FamilyRubiaceae
OriginMalaysia, India
Plant Part UsedLeaf
ExtractHexane
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneBroth dilution assay using BACTEC system
Positive Control Used (conc.)Rifampin (0.125 µg/ml)
Inhibition [%]Crude: 89% and Hexane: 95 %
Activity [MIC] µg/ml32 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified(E)-Phytol
PubChem ID   5280435
Ethnomedicinal InformationAsthma, joint pains, immune problems, pain relief, cellular regeneration, tuberculosis, respiratory disorders
PubMed ID [Source Literature]12410555
Extract PreparationN/A
Chemical Classification [Active Compound]Aliphatic, Alkene, Terpene, Diterpene, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight296.308
Molecular FormulaC20H40O
SMILESOC/C=C(/CCC[C@@H](CCC[C@@H](CCCC(C)C)C)C)C
XLogP8.949
PSA20.230
H-bond Donor1
H-bond Acceptor1
No. of Rotatable Bond Count13
No. of Rings0
No. of N0
No. of O1
No. of S0
Reference(s)1) Saludes JP, Garson MJ, Franzblau SG, Aguinaldo AM.Antitubercular constituents from the hexane fraction of Morinda citrifolia Linn. (Rubiaceae).Phytother Res. 2002 Nov;16(7):683-5

2) http://www.motherherbs.com/morinda-citrifolia.html

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                  Record - 3 of 3   [TOP]
Compound ID4032
Compound Structure
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Plant SourcePourthiaea lucida     Common Name:
Source FamilyRosaceae
Origin
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml12.5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified(E)-Phytol
PubChem ID   5280435
Ethnomedicinal Information
PubMed ID [Source Literature]
Extract Preparation
Chemical Classification [Active Compound]Aliphatic, Alkene, Terpene, Diterpene, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight296.308
Molecular FormulaC20H40O
SMILESOC/C=C(/CCC[C@@H](CCC[C@@H](CCCC(C)C)C)C)C
XLogP8.949
PSA20.230
H-bond Donor1
H-bond Acceptor1
No. of Rotatable Bond Count13
No. of Rings0
No. of N0
No. of O1
No. of S0
Reference(s)1) In silico Comparison of Antimycobacterial Natural Products with Known Antituberculosis Drugs. Marlene Espinoza-Moraga, Nicholas M. Njuguna, Grace Mugumbate, Julio Caballero, and Kelly Chibale. Journal of Chemical Information and Modeling 2013 53 (3), 649-660

2) García, A., Bocanegra-García, V., Palma-Nicolás, J. P., Rivera, G. Vennerstrom, J. L. Recent Advances in Antitubercular Natural Products. Eur. J. Med. Chem. 2012, 49, 1-23

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