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                  Page - 1 of 1                  Record - 1 of 4   [TOP]
Compound ID2051
Compound Structure
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Plant SourceLippia alba (Miller) N. E.Brown     Common Name:
Source FamilyVerbenaceae
OriginColombia, Puerto Rico, India
Plant Part UsedLeaf, stem
ExtractEssential oil (2.5 %)
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMacrodilution method in glass tubes
Positive Control Used (conc.)Rifampin (0.50 µg/ml), Isoniazid (0.03 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml130 ± 95 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedTrans - β - Caryophyllene (5.8 %)
PubChem ID   5281515
Ethnomedicinal InformationDigestive troubles in general, nausea, bronchitis, sore throat, flu, cough, cold, hypertension, skin diseases, wounds, stomach ache, nervous complaints, folklore medicine of Puerto Rico
PubMed ID [Source Literature]19753839
Extract PreparationN/A
Chemical Classification [Active Compound]Alicyclic, Bicyclic, Terpene, Sesquiterpene
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight204.188
Molecular FormulaC15H24
SMILESC1([C@H]2[C@H](C1)C(=C)CC/C=C(/CC2)C)(C)C
XLogP6.044
PSA0.000
H-bond Donor0
H-bond Acceptor0
No. of Rotatable Bond Count0
No. of Rings2
No. of N0
No. of O0
No. of S0
Reference(s)1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60

2) Thierry Hennebelle, Sevser Sahpaz, Henry Joseph, François Bailleul.Ethnopharmacology of Lippia alba.Journal of Ethnopharmacology, Volume 116, Issue 2, 5 March 2008, Pages 211-222

Curator

                  Record - 2 of 4   [TOP]
Compound ID2356
Compound Structure
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Plant SourcePiper auritum     Common Name:Eared Pepper, False Kava (Hawaii), False Kava - Kava, Hierba Santa, Hoja Santa
Source FamilyPiperaceae
OriginColombia
Plant Part UsedLeaf
ExtractEssential oil (2.3 %)
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMacrodilution method in glass tubes
Positive Control Used (conc.)Rifampin (0.50 µg/ml), Isoniazid (0.03 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml400 ± 220 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedTrans - β - Caryophyllene
PubChem ID   5281515
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]19753839
Extract PreparationN/A
Chemical Classification [Active Compound]Alicyclic, Bicyclic, Terpene, Sesquiterpene
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight204.188
Molecular FormulaC15H24
SMILESC1([C@H]2[C@H](C1)C(=C)CC/C=C(/CC2)C)(C)C
XLogP6.044
PSA0.000
H-bond Donor0
H-bond Acceptor0
No. of Rotatable Bond Count0
No. of Rings2
No. of N0
No. of O0
No. of S0
Reference(s)1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60

Curator

                  Record - 3 of 4   [TOP]
Compound ID2371
Compound Structure
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Plant SourcePiper bogotense     Common Name:
Source FamilyPiperaceae
OriginColombia
Plant Part UsedLeaf
ExtractEssential oil (0.2 %)
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMacrodilution method in glass tubes
Positive Control Used (conc.)Rifampin (0.50 µg/ml), Isoniazid (0.03 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml130 ± 95 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedTrans - β - Caryophyllene (3.1 %)
PubChem ID   5281515
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]19753839
Extract PreparationN/A
Chemical Classification [Active Compound]Alicyclic, Bicyclic, Terpene, Sesquiterpene
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight204.188
Molecular FormulaC15H24
SMILESC1([C@H]2[C@H](C1)C(=C)CC/C=C(/CC2)C)(C)C
XLogP6.044
PSA0.000
H-bond Donor0
H-bond Acceptor0
No. of Rotatable Bond Count0
No. of Rings2
No. of N0
No. of O0
No. of S0
Reference(s)1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60

Curator

                  Record - 4 of 4   [TOP]
Compound ID3891
Compound Structure
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Plant SourceHyptis mutabilis     Common Name:Tropical Bushmint
Source FamilyLamiaceae
OriginColombia
Plant Part UsedLeaf, stem
ExtractEssential oil (0.3 %)
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMacrodilution method in glass tubes
Positive Control Used (conc.)Isoniazid (0.19 ± 0.07 µg/ml), Rifampin (0.3 ± 0.21 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml125 ± 0.01 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedTrans - β - Caryophyllene (10.9 %)
PubChem ID   5281515
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19753839
Extract PreparationThe essential oils were extracted from a 300 g sample of plant leaves and stems by microwave - assisted hydrodistillation (30 min, 250 ml water), using a Clevenger - type distillation apparatus and a Dean - Stark distillation trap in a domestic microwave oven. Sodium sulfate was added as a drying agent to the decanted essential oil
Chemical Classification [Active Compound]Alicyclic, Bicyclic, Terpene, Sesquiterpene
Media / Broth Used [Antimicrobial Assay/Test]Lowestein - Jensenn medium, Middlebrook 7H9 medium [The later was supplemented with 10 % OADC (Oleic Acid - Albumin - Dextrose - Catalase) and 0.001 % Tween 80]
Cytotoxicity Assay [AID]NR
Molecular Weight204.188
Molecular FormulaC15H24
SMILESC1([C@H]2[C@H](C1)C(=C)CC/C=C(/CC2)C)(C)C
XLogP6.044
PSA0.000
H-bond Donor0
H-bond Acceptor0
No. of Rotatable Bond Count0
No. of Rings2
No. of N0
No. of O0
No. of S0
Reference(s)1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60

CuratorKeyaMukherjee, Farzana Shamsudeen


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