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                  Page - 1 of 1                  Record - 1 of 5   [TOP]
Compound ID2057
Compound Structure
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Plant SourceLippia alba (Miller) N. E.Brown     Common Name:
Source FamilyVerbenaceae
OriginColombia, Puerto Rico, India
Plant Part UsedLeaf, stem
ExtractEssential oil (1.6 %)
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMacrodilution method in glass tubes
Positive Control Used (conc.)Rifampin (0.50 µg/ml), Isoniazid (0.03 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml130 ± 95 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identifiedα - Humulene (1.4 %)
PubChem ID   5281520
Ethnomedicinal InformationDigestive troubles in general, nausea, bronchitis, sore throat, flu, cough, cold, hypertension, skin diseases, wounds, stomach ache, nervous complaints, folklore medicine of Puerto Rico
PubMed ID [Source Literature]19753839
Extract PreparationN/A
Chemical Classification [Active Compound]Alicyclic, Terpene, Sesquiterpene
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight204.188
Molecular FormulaC15H24
SMILESC1(C/C=C(/CC/C=C(/C/C=C/1)C)C)(C)C
XLogP5.940
PSA0.000
H-bond Donor0
H-bond Acceptor0
No. of Rotatable Bond Count0
No. of Rings1
No. of N0
No. of O0
No. of S0
Reference(s)1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60

2) Thierry Hennebelle, Sevser Sahpaz, Henry Joseph, François Bailleul.Ethnopharmacology of Lippia alba.Journal of Ethnopharmacology, Volume 116, Issue 2, 5 March 2008, Pages 211-222

Curator

                  Record - 2 of 5   [TOP]
Compound ID2416
Compound Structure
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Plant SourcePolyalthia cerasoides (Roxb.) Benth. ex Bedd     Common Name:
Source FamilyAnnonaceae
OriginThailand
Plant Part UsedRoot
Extract
Target BacteriaMycobacterium tuberculosis H37Ra
Assay / Test DoneMicroplate Alamar Blue assay (MABA)
Positive Control Used (conc.)Isoniazid (0.05 µg/ml), Kanamycin (2.5 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml6.25 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identifiedα - Humulene
PubChem ID   5281520
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]17845001
Extract PreparationN/A
Chemical Classification [Active Compound]Alicyclic, Terpene, Sesquiterpene
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight204.188
Molecular FormulaC15H24
SMILESC1(C/C=C(/CC/C=C(/C/C=C/1)C)C)(C)C
XLogP5.940
PSA0.000
H-bond Donor0
H-bond Acceptor0
No. of Rotatable Bond Count0
No. of Rings1
No. of N0
No. of O0
No. of S0
Reference(s)1) Kanokmedhakul S, Kanokmedhakul K, Lekphrom R.Bioactive constituents of the roots of Polyalthia cerasoides.J Nat Prod. 2007 Sep;70(9):1536-8

Curator

                  Record - 3 of 5   [TOP]
Compound ID3866
Compound Structure
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Plant SourceAchyrocline alata     Common Name:NR
Source FamilyAsteraceae (Compositae)
OriginColombia
Plant Part UsedLeaf, stem
ExtractEssential oil (0.3 %)
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMacrodilution method in glass tubes
Positive Control Used (conc.)Isoniazid (0.19 ± 0.07 µg/ml), Rifampin (0.3 ± 0.21 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml62.5 ± 0.01 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identifiedα - Humulene (2.4%)
PubChem ID   5281520
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]19753839
Extract PreparationThe essential oils were extracted from a 300 g sample of plant leaves and stems by microwave - assisted hydrodistillation (30 min, 250 ml water), using a Clevenger - type distillation apparatus and a Dean - Stark distillation trap in a domestic microwave oven. Sodium sulfate was added as a drying agent to the decanted essential oil
Chemical Classification [Active Compound]Alicyclic, Terpene, Sesquiterpene
Media / Broth Used [Antimicrobial Assay/Test]Lowestein - Jensenn medium, Middlebrook 7H9 medium [The later was supplemented with 10 % OADC (Oleic Acid - Albumin - Dextrose - Catalase) and 0.001 % Tween 80]
Cytotoxicity Assay [AID]NR
Molecular Weight204.188
Molecular FormulaC15H24
SMILESC1(C/C=C(/CC/C=C(/C/C=C/1)C)C)(C)C
XLogP5.940
PSA0.000
H-bond Donor0
H-bond Acceptor0
No. of Rotatable Bond Count0
No. of Rings1
No. of N0
No. of O0
No. of S0
Reference(s)1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60

CuratorKeyaMukherjee, Farzana Shamsudeen

                  Record - 4 of 5   [TOP]
Compound ID3879
Compound Structure
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Plant SourceCananga odorata     Common Name:Ylang - Ylang Tree
Source FamilyAnnonaceae
OriginColombia
Plant Part UsedFlower
ExtractEssential oil (1.2 %)
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMacrodilution method in glass tubes
Positive Control Used (conc.)Isoniazid (0.19 ± 0.07 µg/ml), Rifampin (0.3 ± 0.21 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml300 ± 217 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identifiedα - Humulene (2.8 %)
PubChem ID   5281520
Ethnomedicinal InformationStomach ailment, fever, inflammation, burning sensation, malarial fever, asthma with aromatherapy, hypertension, anxiety, depression and as a sexual stimulant
PubMed ID [Source Literature]19753839
Extract PreparationThe essential oils were extracted from a 300 g sample of plant leaves and stems by microwave - assisted hydrodistillation (30 min, 250 ml water), using a Clevenger - type distillation apparatus and a Dean - Stark distillation trap in a domestic microwave oven. Sodium sulfate was added as a drying agent to the decanted essential oil
Chemical Classification [Active Compound]Alicyclic, Terpene, Sesquiterpene
Media / Broth Used [Antimicrobial Assay/Test]Lowestein - Jensenn medium, Middlebrook 7H9 medium [The later was supplemented with 10 % OADC (Oleic Acid - Albumin - Dextrose - Catalase) and 0.001 % Tween 80]
Cytotoxicity Assay [AID]NR
Molecular Weight204.188
Molecular FormulaC15H24
SMILESC1(C/C=C(/CC/C=C(/C/C=C/1)C)C)(C)C
XLogP5.940
PSA0.000
H-bond Donor0
H-bond Acceptor0
No. of Rotatable Bond Count0
No. of Rings1
No. of N0
No. of O0
No. of S0
Reference(s)1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60

2) http://ayurvedicmedicinalplants.com/index.php?option=com_zoom&Itemid=26&page=view&catid=3&key=10&hit=1

CuratorKeyaMukherjee, Farzana Shamsudeen

                  Record - 5 of 5   [TOP]
Compound ID3901
Compound Structure
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Plant SourceLippia origanoides     Common Name:NR
Source FamilyVerbenaceae
OriginColombia
Plant Part UsedLeaf, stem
ExtractEssential oil (3 .1 %)
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMacrodilution method in glass tubes
Positive Control Used (conc.)Isoniazid (0.19 ± 0.07 µg/ml), Rifampin (0.3 ± 0.21 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml125 ± 0.01 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identifiedα - Humulene (1.5 %)
PubChem ID   5281520
Ethnomedicinal InformationNR
PubMed ID [Source Literature]18955515
Extract PreparationThe essential oils were extracted from a 300 g sample of plant leaves and stems by microwave - assisted hydrodistillation (30 min, 250 ml water), using a Clevenger - type distillation apparatus and a Dean - Stark distillation trap in a domestic microwave oven. Sodium sulfate was added as a drying agent to the decanted essential oil
Chemical Classification [Active Compound]Alicyclic, Terpene, Sesquiterpene
Media / Broth Used [Antimicrobial Assay/Test]Lowestein - Jensenn medium, Middlebrook 7H9 medium [The later was supplemented with 10 % OADC (Oleic Acid - Albumin - Dextrose - Catalase) and 0.001 % Tween 80]
Cytotoxicity Assay [AID]NR
Molecular Weight204.188
Molecular FormulaC15H24
SMILESC1(C/C=C(/CC/C=C(/C/C=C/1)C)C)(C)C
XLogP5.940
PSA0.000
H-bond Donor0
H-bond Acceptor0
No. of Rotatable Bond Count0
No. of Rings1
No. of N0
No. of O0
No. of S0
Reference(s)1) Ritz N, Tebruegge M, Connell TG, Sievers A, Robins-Browne R, Curtis N.Susceptibility of Mycobacterium bovis BCG vaccine strains to antituberculous antibiotics.Antimicrob Agents Chemother. 2009 Jan;53(1):316-8

CuratorKeyaMukherjee, Farzana Shamsudeen


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