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                  Page - 1 of 1                  Record - 1 of 4   [TOP]
Compound ID3086
Compound Structure
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Plant SourceFerula communis L.     Common Name:Giant Fennel
Source FamilyApiaceae (Umbelliferae)
OriginCagliari, Sardinia, Italy
Plant Part UsedRoot
ExtractAcetone
Target BacteriaMycobacterium fortuitum (ATCC 6841)
Assay / Test Done
Positive Control Used (conc.)Ethambutol (8 µg/ml), Isoniazid (0.5 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml32 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identifiedω - acetoxy derivative of ferulenol
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]15620264
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Bicyclic, Alkyl, Alkene, Coumarin, Prenylated, O-Acetyl, Phenol
Media / Broth Used [Antimicrobial Assay/Test]Mueller - Hinton Broth
Cytotoxicity Assay [AID]
Molecular Weight424.225
Molecular FormulaC26H32O5
SMILESC1cccc2c1c(c(c(=O)o2)C/C=C(/CC/C=C(/CC/C=C(/COC(=O)C)C)C)C)O
XLogP5.804
PSA63.600
H-bond Donor1
H-bond Acceptor4
No. of Rotatable Bond Count11
No. of Rings2
No. of N0
No. of O5
No. of S0
Reference(s)1) Appendino G, Mercalli E, Fuzzati N, Arnoldi L, Stavri M, Gibbons S, Ballero M, Maxia A.Antimycobacterial coumarins from the sardinian giant fennel (Ferula communis).J Nat Prod. 2004 Dec;67(12):2108-10

CuratorVikramjitmandal

                  Record - 2 of 4   [TOP]
Compound ID3087
Compound Structure
DOWNLOAD:
Plant SourceFerula communis L.     Common Name:Giant Fennel
Source FamilyApiaceae (Umbelliferae)
OriginCagliari, Sardinia, Italy
Plant Part UsedRoot
ExtractAcetone
Target BacteriaMycobacterium phlei (ATCC 11758)
Assay / Test Done
Positive Control Used (conc.)Ethambutol (2 µg/ml), Isoniazid (4 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml8 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identifiedω - acetoxy derivative of ferulenol
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]15620264
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Bicyclic, Alkyl, Alkene, Coumarin, Prenylated, O-Acetyl, Phenol
Media / Broth Used [Antimicrobial Assay/Test]Mueller - Hinton Broth
Cytotoxicity Assay [AID]
Molecular Weight424.225
Molecular FormulaC26H32O5
SMILESC1cccc2c1c(c(c(=O)o2)C/C=C(/CC/C=C(/CC/C=C(/COC(=O)C)C)C)C)O
XLogP5.804
PSA63.600
H-bond Donor1
H-bond Acceptor4
No. of Rotatable Bond Count11
No. of Rings2
No. of N0
No. of O5
No. of S0
Reference(s)1) Appendino G, Mercalli E, Fuzzati N, Arnoldi L, Stavri M, Gibbons S, Ballero M, Maxia A.Antimycobacterial coumarins from the sardinian giant fennel (Ferula communis).J Nat Prod. 2004 Dec;67(12):2108-10

CuratorVikramjitmandal

                  Record - 3 of 4   [TOP]
Compound ID3088
Compound Structure
DOWNLOAD:
Plant SourceFerula communis L.     Common Name:Giant Fennel
Source FamilyApiaceae (Umbelliferae)
OriginCagliari, Sardinia, Italy
Plant Part UsedRoot
ExtractAcetone
Target BacteriaMycobacterium aurum (Pasteur Institute 104482)
Assay / Test Done
Positive Control Used (conc.)Ethambutol (0.5 µg/ml), Isoniazid (2 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml16 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identifiedω - acetoxy derivative of ferulenol
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]15620264
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Bicyclic, Alkyl, Alkene, Coumarin, Prenylated, O-Acetyl, Phenol
Media / Broth Used [Antimicrobial Assay/Test]Mueller - Hinton Broth
Cytotoxicity Assay [AID]
Molecular Weight424.225
Molecular FormulaC26H32O5
SMILESC1cccc2c1c(c(c(=O)o2)C/C=C(/CC/C=C(/CC/C=C(/COC(=O)C)C)C)C)O
XLogP5.804
PSA63.600
H-bond Donor1
H-bond Acceptor4
No. of Rotatable Bond Count11
No. of Rings2
No. of N0
No. of O5
No. of S0
Reference(s)1) Appendino G, Mercalli E, Fuzzati N, Arnoldi L, Stavri M, Gibbons S, Ballero M, Maxia A.Antimycobacterial coumarins from the sardinian giant fennel (Ferula communis).J Nat Prod. 2004 Dec;67(12):2108-10

CuratorVikramjitmandal

                  Record - 4 of 4   [TOP]
Compound ID3089
Compound Structure
DOWNLOAD:
Plant SourceFerula communis L.     Common Name:Giant Fennel
Source FamilyApiaceae (Umbelliferae)
OriginCagliari, Sardinia, Italy
Plant Part UsedRoot
ExtractAcetone
Target BacteriaMycobacterium smegmatis (ATCC 144680)
Assay / Test Done
Positive Control Used (conc.)Ethambutol (0.5 µg/ml), Isoniazid (1 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml8 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identifiedω - acetoxy derivative of ferulenol
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]15620264
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Bicyclic, Alkyl, Alkene, Coumarin, Prenylated, O-Acetyl, Phenol
Media / Broth Used [Antimicrobial Assay/Test]Mueller - Hinton Broth
Cytotoxicity Assay [AID]
Molecular Weight424.225
Molecular FormulaC26H32O5
SMILESC1cccc2c1c(c(c(=O)o2)C/C=C(/CC/C=C(/CC/C=C(/COC(=O)C)C)C)C)O
XLogP5.804
PSA63.600
H-bond Donor1
H-bond Acceptor4
No. of Rotatable Bond Count11
No. of Rings2
No. of N0
No. of O5
No. of S0
Reference(s)1) Appendino G, Mercalli E, Fuzzati N, Arnoldi L, Stavri M, Gibbons S, Ballero M, Maxia A.Antimycobacterial coumarins from the sardinian giant fennel (Ferula communis).J Nat Prod. 2004 Dec;67(12):2108-10

CuratorVikramjitmandal


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