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                  Page - 1 of 1                  Record - 1 of 8   [TOP]
Compound ID1738
Compound Structure
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Plant SourceFerula communis     Common Name:Giant Fennel
Source FamilyApiaceae (Umbelliferae)
OriginSaudi Arabia
Plant Part UsedRhizome
Extract
Target BacteriaMycobacterium intracellulare
Assay / Test Done
Positive Control Used (conc.)Amikacin (0.25 µg/ml), Streptomycin (10 µg/ml), Isoniazid (10 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml1.25 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedFerulenol
PubChem ID   54679300
Ethnomedicinal InformationAnti-mycobacterial
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Bicyclic, Alkyl, Alkene, Coumarin, Prenylated, Phenol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight366.219
Molecular FormulaC24H30O3
SMILESO1c2c(c(O)c(C/C=C(/CC/C=C(/CCC=C(C)C)C)C)c1=O)cccc2
XLogP8.182
PSA37.300
H-bond Donor1
H-bond Acceptor2
No. of Rotatable Bond Count8
No. of Rings2
No. of N0
No. of O3
No. of S0
Reference(s)1) Mohammed A. Al-Yahya, Ilias Muhammad, Humayun H. Mirza, Farouk S. El-Feraly.Antibacterial constituents from the rhizomes of Ferula communis.Phytotherapy Research.12/1998;12(5):335-339

2) http://www.pfaf.org/user/Plant.aspx?LatinName=Ferula+communis

Curator

                  Record - 2 of 8   [TOP]
Compound ID3074
Compound Structure
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Plant SourceFerula communis L.     Common Name:Giant Fennel
Source FamilyApiaceae (Umbelliferae)
OriginCagliari, Sardinia, Italy
Plant Part UsedRoot
ExtractAcetone
Target BacteriaMycobacterium aurum (Pasteur Institute 104482)
Assay / Test Done
Positive Control Used (conc.)Ethambutol (0.5 µg/ml), Isoniazid (2 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml2 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedFerulenol
PubChem ID   54679300
Ethnomedicinal Information
PubMed ID [Source Literature]15620264
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Bicyclic, Alkyl, Alkene, Coumarin, Prenylated, Phenol
Media / Broth Used [Antimicrobial Assay/Test]Mueller - Hinton Broth
Cytotoxicity Assay [AID]
Molecular Weight366.219
Molecular FormulaC24H30O3
SMILESO1c2c(c(O)c(C/C=C(/CC/C=C(/CCC=C(C)C)C)C)c1=O)cccc2
XLogP8.182
PSA37.300
H-bond Donor1
H-bond Acceptor2
No. of Rotatable Bond Count8
No. of Rings2
No. of N0
No. of O3
No. of S0
Reference(s)1) Appendino G, Mercalli E, Fuzzati N, Arnoldi L, Stavri M, Gibbons S, Ballero M, Maxia A.Antimycobacterial coumarins from the sardinian giant fennel (Ferula communis).J Nat Prod. 2004 Dec;67(12):2108-10

CuratorVsheeba, vikramjitmandal

                  Record - 3 of 8   [TOP]
Compound ID3075
Compound Structure
DOWNLOAD:
Plant SourceFerula communis L.     Common Name:Giant Fennel
Source FamilyApiaceae (Umbelliferae)
OriginCagliari, Sardinia, Italy
Plant Part UsedRoot
ExtractAcetone
Target BacteriaMycobacterium fortuitum (ATCC 6841)
Assay / Test Done
Positive Control Used (conc.)Ethambutol (8 µg/ml), Isoniazid (0.5 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml2 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedFerulenol
PubChem ID   54679300
Ethnomedicinal Information
PubMed ID [Source Literature]15620264
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Bicyclic, Alkyl, Alkene, Coumarin, Prenylated, Phenol
Media / Broth Used [Antimicrobial Assay/Test]Mueller - Hinton Broth
Cytotoxicity Assay [AID]
Molecular Weight366.219
Molecular FormulaC24H30O3
SMILESO1c2c(c(O)c(C/C=C(/CC/C=C(/CCC=C(C)C)C)C)c1=O)cccc2
XLogP8.182
PSA37.300
H-bond Donor1
H-bond Acceptor2
No. of Rotatable Bond Count8
No. of Rings2
No. of N0
No. of O3
No. of S0
Reference(s)1) Appendino G, Mercalli E, Fuzzati N, Arnoldi L, Stavri M, Gibbons S, Ballero M, Maxia A.Antimycobacterial coumarins from the sardinian giant fennel (Ferula communis).J Nat Prod. 2004 Dec;67(12):2108-10

CuratorVsheeba, vikramjitmandal

                  Record - 4 of 8   [TOP]
Compound ID3076
Compound Structure
DOWNLOAD:
Plant SourceFerula communis L.     Common Name:Giant Fennel
Source FamilyApiaceae (Umbelliferae)
OriginCagliari, Sardinia, Italy
Plant Part UsedRoot
ExtractAcetone
Target BacteriaMycobacterium phlei (ATCC 11758)
Assay / Test Done
Positive Control Used (conc.)Ethambutol (2 µg/ml), Isoniazid (4 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml2 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedFerulenol
PubChem ID   54679300
Ethnomedicinal Information
PubMed ID [Source Literature]15620264
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Bicyclic, Alkyl, Alkene, Coumarin, Prenylated, Phenol
Media / Broth Used [Antimicrobial Assay/Test]Mueller - Hinton Broth
Cytotoxicity Assay [AID]
Molecular Weight366.219
Molecular FormulaC24H30O3
SMILESO1c2c(c(O)c(C/C=C(/CC/C=C(/CCC=C(C)C)C)C)c1=O)cccc2
XLogP8.182
PSA37.300
H-bond Donor1
H-bond Acceptor2
No. of Rotatable Bond Count8
No. of Rings2
No. of N0
No. of O3
No. of S0
Reference(s)1) Appendino G, Mercalli E, Fuzzati N, Arnoldi L, Stavri M, Gibbons S, Ballero M, Maxia A.Antimycobacterial coumarins from the sardinian giant fennel (Ferula communis).J Nat Prod. 2004 Dec;67(12):2108-10

CuratorVsheeba, vikramjitmandal

                  Record - 5 of 8   [TOP]
Compound ID3077
Compound Structure
DOWNLOAD:
Plant SourceFerula communis L.     Common Name:Giant Fennel
Source FamilyApiaceae (Umbelliferae)
OriginCagliari, Sardinia, Italy
Plant Part UsedRoot
ExtractAcetone
Target BacteriaMycobacterium smegmatis (ATCC 14468)
Assay / Test Done
Positive Control Used (conc.)Ethambutol (0.5 µg/ml), Isoniazid (1 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml0.5 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedFerulenol
PubChem ID   54679300
Ethnomedicinal Information
PubMed ID [Source Literature]15620264
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Bicyclic, Alkyl, Alkene, Coumarin, Prenylated, Phenol
Media / Broth Used [Antimicrobial Assay/Test]Mueller - Hinton Broth
Cytotoxicity Assay [AID]
Molecular Weight366.219
Molecular FormulaC24H30O3
SMILESO1c2c(c(O)c(C/C=C(/CC/C=C(/CCC=C(C)C)C)C)c1=O)cccc2
XLogP8.182
PSA37.300
H-bond Donor1
H-bond Acceptor2
No. of Rotatable Bond Count8
No. of Rings2
No. of N0
No. of O3
No. of S0
Reference(s)1) Appendino G, Mercalli E, Fuzzati N, Arnoldi L, Stavri M, Gibbons S, Ballero M, Maxia A.Antimycobacterial coumarins from the sardinian giant fennel (Ferula communis).J Nat Prod. 2004 Dec;67(12):2108-10

CuratorVsheeba, vikramjitmandal

                  Record - 6 of 8   [TOP]
Compound ID3967
Compound Structure
DOWNLOAD:
Plant SourceFerula communis     Common Name:Giant Fennel
Source FamilyApiaceae (Umbelliferae)
OriginSaudi Arabia
Plant Part UsedRhizome
Extract
Target BacteriaMycobacterium smegmatis
Assay / Test Done
Positive Control Used (conc.)Amikacin (0.25 µg/ml), Streptomycin (10 µg/ml), Isoniazid (10 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml1.25 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedFerulenol
PubChem ID   54679300
Ethnomedicinal InformationAnti-mycobacterial
PubMed ID [Source Literature]
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Bicyclic, Alkyl, Alkene, Coumarin, Prenylated, Phenol
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight366.219
Molecular FormulaC24H30O3
SMILESO1c2c(c(O)c(C/C=C(/CC/C=C(/CCC=C(C)C)C)C)c1=O)cccc2
XLogP8.182
PSA37.300
H-bond Donor1
H-bond Acceptor2
No. of Rotatable Bond Count8
No. of Rings2
No. of N0
No. of O3
No. of S0
Reference(s)1) Mohammed A. Al-Yahya, Ilias Muhammad, Humayun H. Mirza, Farouk S. El-Feraly.Antibacterial constituents from the rhizomes of Ferula communis.Phytotherapy Research.12/1998;12(5):335-339

2) http://www.pfaf.org/user/Plant.aspx?LatinName=Ferula+communis

Curator

                  Record - 7 of 8   [TOP]
Compound ID3966
Compound Structure
DOWNLOAD:
Plant SourceFerula communis     Common Name:Giant Fennel
Source FamilyApiaceae (Umbelliferae)
OriginSaudi Arabia
Plant Part UsedRhizome
Extract
Target BacteriaMycobacterium chelonei
Assay / Test Done
Positive Control Used (conc.)Amikacin (0.25 µg/ml), Streptomycin (10 µg/ml), Isoniazid (10 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml1.25 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedFerulenol
PubChem ID   54679300
Ethnomedicinal InformationAnti-mycobacterial
PubMed ID [Source Literature]
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Bicyclic, Alkyl, Alkene, Coumarin, Prenylated, Phenol
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight366.219
Molecular FormulaC24H30O3
SMILESO1c2c(c(O)c(C/C=C(/CC/C=C(/CCC=C(C)C)C)C)c1=O)cccc2
XLogP8.182
PSA37.300
H-bond Donor1
H-bond Acceptor2
No. of Rotatable Bond Count8
No. of Rings2
No. of N0
No. of O3
No. of S0
Reference(s)1) Mohammed A. Al-Yahya, Ilias Muhammad, Humayun H. Mirza, Farouk S. El-Feraly.Antibacterial constituents from the rhizomes of Ferula communis.Phytotherapy Research.12/1998;12(5):335-339

2) http://www.pfaf.org/user/Plant.aspx?LatinName=Ferula+communis

Curator

                  Record - 8 of 8   [TOP]
Compound ID3965
Compound Structure
DOWNLOAD:
Plant SourceFerula communis     Common Name:Giant Fennel
Source FamilyApiaceae (Umbelliferae)
OriginSaudi Arabia
Plant Part UsedRhizome
Extract
Target BacteriaMycobacterium xenopi
Assay / Test Done
Positive Control Used (conc.)Amikacin (0.25 µg/ml), Streptomycin (10 µg/ml), Isoniazid (10 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml1.25 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedFerulenol
PubChem ID   54679300
Ethnomedicinal InformationAnti-mycobacterial
PubMed ID [Source Literature]
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Bicyclic, Alkyl, Alkene, Coumarin, Prenylated, Phenol
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight366.219
Molecular FormulaC24H30O3
SMILESO1c2c(c(O)c(C/C=C(/CC/C=C(/CCC=C(C)C)C)C)c1=O)cccc2
XLogP8.182
PSA37.300
H-bond Donor1
H-bond Acceptor2
No. of Rotatable Bond Count8
No. of Rings2
No. of N0
No. of O3
No. of S0
Reference(s)1) Mohammed A. Al-Yahya, Ilias Muhammad, Humayun H. Mirza, Farouk S. El-Feraly.Antibacterial constituents from the rhizomes of Ferula communis.Phytotherapy Research.12/1998;12(5):335-339

2) http://www.pfaf.org/user/Plant.aspx?LatinName=Ferula+communis

Curator


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