| Compound ID | 3413 |
| Compound Structure |  |
| Plant Source | Physalis angulata L. Common Name:Camapu, Gooseberry, Hogweed, Balloon Cherry (English) |
| Source Family | Solanaceae |
| Origin | Brazil |
| Plant Part Used | Aerial |
| Extract | Chloroform |
| Target Bacteria | Mycobacterium tuberculosis H37Rv |
| Assay / Test Done | Microplate Alamar Blue Assay (MABA) |
| Positive Control Used (conc.) | Rifampin (0.2 µg/ml) |
| Inhibition [%] | NR |
| Activity [MIC] µg/ml | > 128 µg/ml |
| Activity (In terms of dilution) | NR |
| Activity (Zone of inhibition in mm) | NR |
| Active Compound Identified | Physalin B |
| PubChem ID | 5488849 |
| Ethnomedicinal Information | Tumors, gastric troubles, diuretic, earache |
| PubMed ID [Source Literature] | 12203265 |
| Extract Preparation | Aerial parts of P. angulata (83.56 g) were extracted with CHCl3. After solvent removal, the crude CHCl3 extract A (3.65 g) was fractionated over a silica gel column using Hex – AcOEt (7:3 - 3:7) |
| Chemical Classification [Active Compound] | Alicyclic, Polycyclic, Steroid, Lactone, Ketone, Alcohol |
| Media / Broth Used [Antimicrobial Assay/Test] | Middlebrook liquid medium 7H9 |
| Cytotoxicity Assay [AID] | NR |
| Molecular Weight | 510.189 |
| Molecular Formula | C28H30O9 |
| SMILES | O1C23C4C5(CC6OC(=O)C5COC1(C4=O)C1C(CCC2(O)C(=O)OC36C)C2(C(=CC1)CC=CC2=O)C)C |
| XLogP | 0.685 |
| PSA | 125.430 |
| H-bond Donor | 1 |
| H-bond Acceptor | 9 |
| No. of Rotatable Bond Count | 0 |
| No. of Rings | 8 |
| No. of N | 0 |
| No. of O | 9 |
| No. of S | 0 |
| Reference(s) | 1) Januário AH, Filho ER, Pietro RC, Kashima S, Sato DN, França SC.Antimycobacterial physalins from Physalis angulata L. (Solanaceae).Phytother Res. 2002 Aug;16(5):445-8
2) Jain, S.K., 1991. Dictionary of Indian Folk Medicine and Ethnobotany. Deep Publications, New Delhi, India
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| Curator | Wvarsha, rachanake |
