BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 17 [TOP]

Compound ID

2899

Compound Structure

Plant Source

Aristolochia taliscana Hook. Common Name:Dutchman's Pipes

Source Family

Aristolochiaceae

Origin

Mexico

Plant Part Used

Root

Extract

N - hexane

Target Bacteria

Mycobacterium tuberculosis H37Rv (ATCC 27 294)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Streptomycin (0.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.1 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Licarin A

PubChem ID

6442393

Ethnomedicinal Information

Cough and snake bites

PubMed ID [Source Literature]

20209328

Extract Preparation

Powdered air - dried roots (1.5 kg) were macerated (3 × 48 h) with 12 l of n - Hexane. The extract was filtered and evaporated in vacuo to yield 33 g of the crude extract

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Furanoid, Alkene, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

J774A.1 murine macrophage cell line (ATCC HB - 197) using the trypan blue exclusion test

Molecular Weight

326.152

Molecular Formula

C₂₀H₂₂O₄

SMILES

O1[C@H]([C@@H](c2c1c(OC)cc(c2)/C=C/C)C)c1cc(OC)c(O)cc1

XLogP

4.363

PSA

47.920

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) León-Díaz R, Meckes M, Said-Fernández S, Molina-Salinas GM, Vargas-Villarreal J, Torres J, Luna-Herrera J, Jiménez-Arellanes A.Antimycobacterial neolignans isolated from Aristolochia taliscana.Mem Inst Oswaldo Cruz. 2010 Feb;105(1):45-51

Curator

Vikramjitmandal

Record - 2 of 17 [TOP]

Compound ID

2900

Compound Structure

Plant Source

Aristolochia taliscana Hook. Common Name:Dutchman's Pipes

Source Family

Aristolochiaceae

Origin

Mexico

Plant Part Used

Root

Extract

N - hexane

Target Bacteria

Mycobacterium tuberculosis H37Rv (ATCC 35822) (Isoniazid resistant)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Streptomycin (0.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.1 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

3.12 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Licarin A

PubChem ID

6442393

Ethnomedicinal Information

Cough and snake bites

PubMed ID [Source Literature]

20209328

Extract Preparation

Powdered air - dried roots (1.5 kg) were macerated (3 × 48 h) with 12 l of n - Hexane. The extract was filtered and evaporated in vacuo to yield 33 g of the crude extract

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Furanoid, Alkene, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

J774A.1 murine macrophage cell line (ATCC HB - 197) using the trypan blue exclusion test

Molecular Weight

326.152

Molecular Formula

C₂₀H₂₂O₄

SMILES

O1[C@H]([C@@H](c2c1c(OC)cc(c2)/C=C/C)C)c1cc(OC)c(O)cc1

XLogP

4.363

PSA

47.920

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 3 of 17 [TOP]

Compound ID

2901

Compound Structure

Plant Source

Aristolochia taliscana Hook. Common Name:Dutchman's Pipes

Source Family

Aristolochiaceae

Origin

Mexico

Plant Part Used

Root

Extract

N - hexane

Target Bacteria

Mycobacterium tuberculosis H37Rv (ATCC 35838) (Rifampin resistant)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Streptomycin (0.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.1 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

6.25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Licarin A

PubChem ID

6442393

Ethnomedicinal Information

Cough and snake bites

PubMed ID [Source Literature]

20209328

Extract Preparation

Powdered air - dried roots (1.5 kg) were macerated (3 × 48 h) with 12 l of n - Hexane. The extract was filtered and evaporated in vacuo to yield 33 g of the crude extract

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Furanoid, Alkene, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

J774A.1 murine macrophage cell line (ATCC HB - 197) using the trypan blue exclusion test

Molecular Weight

326.152

Molecular Formula

C₂₀H₂₂O₄

SMILES

O1[C@H]([C@@H](c2c1c(OC)cc(c2)/C=C/C)C)c1cc(OC)c(O)cc1

XLogP

4.363

PSA

47.920

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 4 of 17 [TOP]

Compound ID

2902

Compound Structure

Plant Source

Aristolochia taliscana Hook. Common Name:Dutchman's Pipes

Source Family

Aristolochiaceae

Origin

Mexico

Plant Part Used

Root

Extract

N - hexane

Target Bacteria

Mycobacterium tuberculosis H37Rv (ATCC 35820) (Streptomycin resistant)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Streptomycin (0.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.1 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

3.12 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Licarin A

PubChem ID

6442393

Ethnomedicinal Information

Cough and snake bites

PubMed ID [Source Literature]

20209328

Extract Preparation

Powdered air - dried roots (1.5 kg) were macerated (3 × 48 h) with 12 l of n - Hexane. The extract was filtered and evaporated in vacuo to yield 33 g of the crude extract

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Furanoid, Alkene, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

J774A.1 murine macrophage cell line (ATCC HB - 197) using the trypan blue exclusion test

Molecular Weight

326.152

Molecular Formula

C₂₀H₂₂O₄

SMILES

O1[C@H]([C@@H](c2c1c(OC)cc(c2)/C=C/C)C)c1cc(OC)c(O)cc1

XLogP

4.363

PSA

47.920

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 5 of 17 [TOP]

Compound ID

2903

Compound Structure

Plant Source

Aristolochia taliscana Hook. Common Name:Dutchman's Pipes

Source Family

Aristolochiaceae

Origin

Mexico

Plant Part Used

Root

Extract

N - hexane

Target Bacteria

Mycobacterium tuberculosis H37Rv (ATCC 35837) (Ethambutol resistant)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Streptomycin (0.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.1 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

6.25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Licarin A

PubChem ID

6442393

Ethnomedicinal Information

Cough and snake bites

PubMed ID [Source Literature]

20209328

Extract Preparation

Powdered air - dried roots (1.5 kg) were macerated (3 × 48 h) with 12 l of n - Hexane. The extract was filtered and evaporated in vacuo to yield 33 g of the crude extract

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Furanoid, Alkene, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

J774A.1 murine macrophage cell line (ATCC HB - 197) using the trypan blue exclusion test

Molecular Weight

326.152

Molecular Formula

C₂₀H₂₂O₄

SMILES

O1[C@H]([C@@H](c2c1c(OC)cc(c2)/C=C/C)C)c1cc(OC)c(O)cc1

XLogP

4.363

PSA

47.920

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 6 of 17 [TOP]

Compound ID

2904

Compound Structure

Plant Source

Aristolochia taliscana Hook. Common Name:Dutchman's Pipes

Source Family

Aristolochiaceae

Origin

Mexico

Plant Part Used

Root

Extract

N - hexane

Target Bacteria

Mycobacterium tuberculosis (Clinical isolate MMDO)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Streptomycin (0.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.1 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

3.12 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Licarin A

PubChem ID

6442393

Ethnomedicinal Information

Cough and snake bites

PubMed ID [Source Literature]

20209328

Extract Preparation

Powdered air - dried roots (1.5 kg) were macerated (3 × 48 h) with 12 l of n - Hexane. The extract was filtered and evaporated in vacuo to yield 33 g of the crude extract

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Furanoid, Alkene, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

J774A.1 murine macrophage cell line (ATCC HB - 197) using the trypan blue exclusion test

Molecular Weight

326.152

Molecular Formula

C₂₀H₂₂O₄

SMILES

O1[C@H]([C@@H](c2c1c(OC)cc(c2)/C=C/C)C)c1cc(OC)c(O)cc1

XLogP

4.363

PSA

47.920

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 7 of 17 [TOP]

Compound ID

2905

Compound Structure

Plant Source

Aristolochia taliscana Hook. Common Name:Dutchman's Pipes

Source Family

Aristolochiaceae

Origin

Mexico

Plant Part Used

Root

Extract

N - hexane

Target Bacteria

Mycobacterium tuberculosis (clinical isolate MTY650)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Streptomycin (0.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.1 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

6.25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Licarin A

PubChem ID

6442393

Ethnomedicinal Information

Cough and snake bites

PubMed ID [Source Literature]

20209328

Extract Preparation

Powdered air - dried roots (1.5 kg) were macerated (3 × 48 h) with 12 l of n - Hexane. The extract was filtered and evaporated in vacuo to yield 33 g of the crude extract

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Furanoid, Alkene, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

J774A.1 murine macrophage cell line (ATCC HB - 197) using the trypan blue exclusion test

Molecular Weight

326.152

Molecular Formula

C₂₀H₂₂O₄

SMILES

O1[C@H]([C@@H](c2c1c(OC)cc(c2)/C=C/C)C)c1cc(OC)c(O)cc1

XLogP

4.363

PSA

47.920

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 8 of 17 [TOP]

Compound ID

2906

Compound Structure

Plant Source

Aristolochia taliscana Hook. Common Name:Dutchman's Pipes

Source Family

Aristolochiaceae

Origin

Mexico

Plant Part Used

Root

Extract

N - hexane

Target Bacteria

Mycobacterium tuberculosis (clinical isolate MTY663)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Streptomycin (0.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.1 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

12.5 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Licarin A

PubChem ID

6442393

Ethnomedicinal Information

Cough and snake bites

PubMed ID [Source Literature]

20209328

Extract Preparation

Powdered air - dried roots (1.5 kg) were macerated (3 × 48 h) with 12 l of n - Hexane. The extract was filtered and evaporated in vacuo to yield 33 g of the crude extract

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Furanoid, Alkene, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

J774A.1 murine macrophage cell line (ATCC HB - 197) using the trypan blue exclusion test

Molecular Weight

326.152

Molecular Formula

C₂₀H₂₂O₄

SMILES

O1[C@H]([C@@H](c2c1c(OC)cc(c2)/C=C/C)C)c1cc(OC)c(O)cc1

XLogP

4.363

PSA

47.920

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 9 of 17 [TOP]

Compound ID

2907

Compound Structure

Plant Source

Aristolochia taliscana Hook. Common Name:Dutchman's Pipes

Source Family

Aristolochiaceae

Origin

Mexico

Plant Part Used

Root

Extract

N - hexane

Target Bacteria

Mycobacterium tuberculosis (clinical isolate MTY675)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Streptomycin (0.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.1 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

12.5 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Licarin A

PubChem ID

6442393

Ethnomedicinal Information

Cough and snake bites

PubMed ID [Source Literature]

20209328

Extract Preparation

Powdered air - dried roots (1.5 kg) were macerated (3 × 48 h) with 12 l of n - Hexane. The extract was filtered and evaporated in vacuo to yield 33 g of the crude extract

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Furanoid, Alkene, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

J774A.1 murine macrophage cell line (ATCC HB - 197) using the trypan blue exclusion test

Molecular Weight

326.152

Molecular Formula

C₂₀H₂₂O₄

SMILES

O1[C@H]([C@@H](c2c1c(OC)cc(c2)/C=C/C)C)c1cc(OC)c(O)cc1

XLogP

4.363

PSA

47.920

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 10 of 17 [TOP]

Compound ID

2908

Compound Structure

Plant Source

Aristolochia taliscana Hook. Common Name:Dutchman's Pipes

Source Family

Aristolochiaceae

Origin

Mexico

Plant Part Used

Root

Extract

N - hexane

Target Bacteria

Mycobacterium tuberculosis (clinical isolate MTY282)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Streptomycin (0.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.1 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

12.5 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Licarin A

PubChem ID

6442393

Ethnomedicinal Information

Cough and snake bites

PubMed ID [Source Literature]

20209328

Extract Preparation

Powdered air - dried roots (1.5 kg) were macerated (3 × 48 h) with 12 l of n - Hexane. The extract was filtered and evaporated in vacuo to yield 33 g of the crude extract

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Furanoid, Alkene, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

J774A.1 murine macrophage cell line (ATCC HB - 197) using the trypan blue exclusion test

Molecular Weight

326.152

Molecular Formula

C₂₀H₂₂O₄

SMILES

O1[C@H]([C@@H](c2c1c(OC)cc(c2)/C=C/C)C)c1cc(OC)c(O)cc1

XLogP

4.363

PSA

47.920

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 11 of 17 [TOP]

Compound ID

2909

Compound Structure

Plant Source

Aristolochia taliscana Hook. Common Name:Dutchman's Pipes

Source Family

Aristolochiaceae

Origin

Mexico

Plant Part Used

Root

Extract

N - hexane

Target Bacteria

Mycobacterium tuberculosis (Clinical isolate HG8)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Streptomycin (0.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.1 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

3.12 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Licarin A

PubChem ID

6442393

Ethnomedicinal Information

Cough and snake bites

PubMed ID [Source Literature]

20209328

Extract Preparation

Powdered air - dried roots (1.5 kg) were macerated (3 × 48 h) with 12 l of n - Hexane. The extract was filtered and evaporated in vacuo to yield 33 g of the crude extract

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Furanoid, Alkene, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

J774A.1 murine macrophage cell line (ATCC HB - 197) using the trypan blue exclusion test

Molecular Weight

326.152

Molecular Formula

C₂₀H₂₂O₄

SMILES

O1[C@H]([C@@H](c2c1c(OC)cc(c2)/C=C/C)C)c1cc(OC)c(O)cc1

XLogP

4.363

PSA

47.920

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 12 of 17 [TOP]

Compound ID

2910

Compound Structure

Plant Source

Aristolochia taliscana Hook. Common Name:Dutchman's Pipes

Source Family

Aristolochiaceae

Origin

Mexico

Plant Part Used

Root

Extract

N - hexane

Target Bacteria

Mycobacterium tuberculosis (Clinical isolate SIN3)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Streptomycin (0.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.1 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

6.25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Licarin A

PubChem ID

6442393

Ethnomedicinal Information

Cough and snake bites

PubMed ID [Source Literature]

20209328

Extract Preparation

Powdered air - dried roots (1.5 kg) were macerated (3 × 48 h) with 12 l of n - Hexane. The extract was filtered and evaporated in vacuo to yield 33 g of the crude extract

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Furanoid, Alkene, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

J774A.1 murine macrophage cell line (ATCC HB - 197) using the trypan blue exclusion test

Molecular Weight

326.152

Molecular Formula

C₂₀H₂₂O₄

SMILES

O1[C@H]([C@@H](c2c1c(OC)cc(c2)/C=C/C)C)c1cc(OC)c(O)cc1

XLogP

4.363

PSA

47.920

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 13 of 17 [TOP]

Compound ID

2911

Compound Structure

Plant Source

Aristolochia taliscana Hook. Common Name:Dutchman's Pipes

Source Family

Aristolochiaceae

Origin

Mexico

Plant Part Used

Root

Extract

N - hexane

Target Bacteria

Mycobacterium tuberculosis (clinical isolate MTY234)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Streptomycin (0.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.1 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

12.5 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Licarin A

PubChem ID

6442393

Ethnomedicinal Information

Cough and snake bites

PubMed ID [Source Literature]

20209328

Extract Preparation

Powdered air - dried roots (1.5 kg) were macerated (3 × 48 h) with 12 l of n - Hexane. The extract was filtered and evaporated in vacuo to yield 33 g of the crude extract

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Furanoid, Alkene, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

J774A.1 murine macrophage cell line (ATCC HB - 197) using the trypan blue exclusion test

Molecular Weight

326.152

Molecular Formula

C₂₀H₂₂O₄

SMILES

O1[C@H]([C@@H](c2c1c(OC)cc(c2)/C=C/C)C)c1cc(OC)c(O)cc1

XLogP

4.363

PSA

47.920

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 14 of 17 [TOP]

Compound ID

2912

Compound Structure

Plant Source

Aristolochia taliscana Hook. Common Name:Dutchman's Pipes

Source Family

Aristolochiaceae

Origin

Mexico

Plant Part Used

Root

Extract

N - hexane

Target Bacteria

Mycobacterium tuberculosis (clinical isolate MTY112)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Streptomycin (0.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.1 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

12.5 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Licarin A

PubChem ID

6442393

Ethnomedicinal Information

Cough and snake bites

PubMed ID [Source Literature]

20209328

Extract Preparation

Powdered air - dried roots (1.5 kg) were macerated (3 × 48 h) with 12 l of n - Hexane. The extract was filtered and evaporated in vacuo to yield 33 g of the crude extract

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Furanoid, Alkene, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

J774A.1 murine macrophage cell line (ATCC HB - 197) using the trypan blue exclusion test

Molecular Weight

326.152

Molecular Formula

C₂₀H₂₂O₄

SMILES

O1[C@H]([C@@H](c2c1c(OC)cc(c2)/C=C/C)C)c1cc(OC)c(O)cc1

XLogP

4.363

PSA

47.920

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 15 of 17 [TOP]

Compound ID

2913

Compound Structure

Plant Source

Aristolochia taliscana Hook. Common Name:Dutchman's Pipes

Source Family

Aristolochiaceae

Origin

Mexico

Plant Part Used

Root

Extract

N - hexane

Target Bacteria

Mycobacterium tuberculosis (clinical isolate MTY559)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Streptomycin (0.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.1 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

12.5 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Licarin A

PubChem ID

6442393

Ethnomedicinal Information

Cough and snake bites

PubMed ID [Source Literature]

20209328

Extract Preparation

Powdered air - dried roots (1.5 kg) were macerated (3 × 48 h) with 12 l of n - Hexane. The extract was filtered and evaporated in vacuo to yield 33 g of the crude extract

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Furanoid, Alkene, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

J774A.1 murine macrophage cell line (ATCC HB - 197) using the trypan blue exclusion test

Molecular Weight

326.152

Molecular Formula

C₂₀H₂₂O₄

SMILES

O1[C@H]([C@@H](c2c1c(OC)cc(c2)/C=C/C)C)c1cc(OC)c(O)cc1

XLogP

4.363

PSA

47.920

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 16 of 17 [TOP]

Compound ID

2914

Compound Structure

Plant Source

Aristolochia taliscana Hook. Common Name:Dutchman's Pipes

Source Family

Aristolochiaceae

Origin

Mexico

Plant Part Used

Root

Extract

N - hexane

Target Bacteria

Mycobacterium tuberculosis (Clinical isolate SIN4)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Streptomycin (0.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.1 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

3.12 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Licarin A

PubChem ID

6442393

Ethnomedicinal Information

Cough and snake bites

PubMed ID [Source Literature]

20209328

Extract Preparation

Powdered air - dried roots (1.5 kg) were macerated (3 × 48 h) with 12 l of n - Hexane. The extract was filtered and evaporated in vacuo to yield 33 g of the crude extract

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Furanoid, Alkene, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

J774A.1 murine macrophage cell line (ATCC HB - 197) using the trypan blue exclusion test

Molecular Weight

326.152

Molecular Formula

C₂₀H₂₂O₄

SMILES

O1[C@H]([C@@H](c2c1c(OC)cc(c2)/C=C/C)C)c1cc(OC)c(O)cc1

XLogP

4.363

PSA

47.920

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal, farzana-shamsudeen-shamsudeen

Record - 17 of 17 [TOP]

Compound ID

2915

Compound Structure

Plant Source

Aristolochia taliscana Hook. Common Name:Dutchman's Pipes

Source Family

Aristolochiaceae

Origin

Mexico

Plant Part Used

Root

Extract

N - hexane

Target Bacteria

Mycobacterium tuberculosis (clinical isolate MTY172)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Streptomycin (0.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.1 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

12.5 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Licarin A

PubChem ID

6442393

Ethnomedicinal Information

Cough and snake bites

PubMed ID [Source Literature]

20209328

Extract Preparation

Powdered air - dried roots (1.5 kg) were macerated (3 × 48 h) with 12 l of n - Hexane. The extract was filtered and evaporated in vacuo to yield 33 g of the crude extract

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Furanoid, Alkene, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

J774A.1 murine macrophage cell line (ATCC HB - 197) using the trypan blue exclusion test

Molecular Weight

326.152

Molecular Formula

C₂₀H₂₂O₄

SMILES

O1[C@H]([C@@H](c2c1c(OC)cc(c2)/C=C/C)C)c1cc(OC)c(O)cc1

XLogP

4.363

PSA

47.920

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal, farzana-shamsudeen-shamsudeen

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