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                  Page - 1 of 1                  Record - 1 of 3   [TOP]
Compound ID1069
Compound Structure
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Plant SourceAgelica sinensis     Common Name:Female Ginseng
Source FamilyApiaceae (Umbelliferae)
OriginChina
Plant Part UsedRoot
ExtractPetroleum ether, chloroform
Target BacteriaMycobacterium tuberculosis (Erdman)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Rifampin (0.05 µg/ml)
Inhibition [%]>= 90 %
Activity [MIC] µg/ml49.5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedOplopandiol
PubChem ID   6474833
Ethnomedicinal InformationTo treat gynecological ailments, fatigue, mild anemia and high blood pressure
PubMed ID [Source Literature]18567055, 12696940
Extract PreparationN/A
Chemical Classification [Active Compound]Aliphatic, Alkene, Alkyne, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight262.193
Molecular FormulaC17H26O2
SMILESO[C@@H](/C=CCCCCCCC)C#CC#C[C@@H](O)CC
XLogP4.977
PSA40.460
H-bond Donor2
H-bond Acceptor2
No. of Rotatable Bond Count8
No. of Rings0
No. of N0
No. of O2
No. of S0
Reference(s)1) Deng S, Wang Y, Inui T, Chen SN, Farnsworth NR, Cho S, Franzblau SG, Pauli GF.Anti-TB polyynes from the roots of Angelica sinensis.Phytother Res. 2008 Jul;22(7):878-82

2) Zhao KJ, Dong TT, Tu PF, Song ZH, Lo CK, Tsim KW (April 2003).Molecular genetic and chemical assessment of radix Angelica (Danggui) in China. J. Agric. Food Chem. 51 (9): 2576.83

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                  Record - 2 of 3   [TOP]
Compound ID2276
Compound Structure
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Plant SourceOplopanax horridus Smith Miq.     Common Name:Devil's Club
Source FamilyAraliaceae
OriginUSA
Plant Part UsedInner bark
ExtractMethanol, dichloromethane
Target BacteriaMycobacterium tuberculosis, Mycobacterium avium
Assay / Test DoneDisk Diffusion Assay
Positive Control Used (conc.)Isoniazid
Inhibition [%]
Activity [MIC] µg/ml10 µg/disk
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedOplopandiol
PubChem ID   6474833
Ethnomedicinal InformationDiabetes, rheumatism, tuberculosis, colds, headaches and lung ailments
PubMed ID [Source Literature]9392889
Extract PreparationN/A
Chemical Classification [Active Compound]Aliphatic, Alkene, Alkyne, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight262.193
Molecular FormulaC17H26O2
SMILESO[C@@H](/C=CCCCCCCC)C#CC#C[C@@H](O)CC
XLogP4.977
PSA40.460
H-bond Donor2
H-bond Acceptor2
No. of Rotatable Bond Count8
No. of Rings0
No. of N0
No. of O2
No. of S0
Reference(s)1) Kobaisy M, Abramowski Z, Lermer L, Saxena G, Hancock RE, Towers GH, Doxsee D, Stokes RW.Antimycobacterial polyynes of Devils Club (Oplopanax horridus), a North American native medicinal plant.J Nat Prod. 1997 Nov;60(11):1210-3

2) Turner, N. J., L. C. Thompson, M. T. Thompson and A. Z. York. 1990. Thompson Ethnobotany: Knowledge and Usage of Plants by the Thompson Indians of British Columbia. Victoria, British Columbia, Royal British Columbia Museum

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                  Record - 3 of 3   [TOP]
Compound ID1074
Compound Structure
DOWNLOAD:
Plant SourceAgelica sinensis     Common Name:Female Ginseng
Source FamilyApiaceae (Umbelliferae)
OriginChina
Plant Part UsedRoot
ExtractPetroleum ether, chloroform
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Rifampin (0.06 µg/ml)
Inhibition [%]>= 90 %
Activity [MIC] µg/ml50.2 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedOplopandiol
PubChem ID   6474833
Ethnomedicinal InformationTo treat gynecological ailments, fatigue, mild anemia and high blood pressure
PubMed ID [Source Literature]18567055, 12696940
Extract PreparationN/A
Chemical Classification [Active Compound]Aliphatic, Alkene, Alkyne, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight262.193
Molecular FormulaC17H26O2
SMILESO[C@@H](/C=CCCCCCCC)C#CC#C[C@@H](O)CC
XLogP4.977
PSA40.460
H-bond Donor2
H-bond Acceptor2
No. of Rotatable Bond Count8
No. of Rings0
No. of N0
No. of O2
No. of S0
Reference(s)1) Deng S, Wang Y, Inui T, Chen SN, Farnsworth NR, Cho S, Franzblau SG, Pauli GF.Anti-TB polyynes from the roots of Angelica sinensis.Phytother Res. 2008 Jul;22(7):878-82

2) Zhao KJ, Dong TT, Tu PF, Song ZH, Lo CK, Tsim KW (April 2003).Molecular genetic and chemical assessment of radix Angelica (Danggui) in China. J. Agric. Food Chem. 51 (9): 2576.83

Curator


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