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                  Page - 1 of 1                  Record - 1 of 3   [TOP]
Compound ID3380
Compound Structure
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Plant SourceTabernaemontana citrifolia     Common Name:NR
Source FamilyApocynaceae
OriginGuadeloupe
Plant Part UsedNR
ExtractNR
Target BacteriaMycobacterium kansasii (Clinical isolate 94 - 069)
Assay / Test DoneNR
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/mlBactec: 100 µg/ml, 7H11 agar: 100 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedVoacangine
PubChem ID   73255
Ethnomedicinal InformationAntimycobacterial
PubMed ID [Source Literature]9626931
Extract PreparationThe dried powdered material was moistened with 25 % NH4OH, and extracted by chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH4OH, and extracted with chloroform. The organic phase was washed with water, and dried over Na2SO4. The organic extracts were evaporated and subjected to chromatography on silica gel
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Indole, Alkaloid, Ether
Media / Broth Used [Antimicrobial Assay/Test]Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium
Cytotoxicity Assay [AID]NR
Molecular Weight368.210
Molecular FormulaC22H28N2O3
SMILESO(C(=O)[C@]12[C@H]3N(C[C@H](C1)C[C@@H]3CC)CCc1c2[nH]c2c1cc(OC)cc2)C
XLogP3.286
PSA54.560
H-bond Donor1
H-bond Acceptor5
No. of Rotatable Bond Count4
No. of Rings3
No. of N2
No. of O3
No. of S0
Reference(s)1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73

CuratorVikramjitmandal, rachanake

                  Record - 2 of 3   [TOP]
Compound ID3381
Compound Structure
DOWNLOAD:
Plant SourceTabernaemontana citrifolia     Common Name:NR
Source FamilyApocynaceae
OriginGuadeloupe
Plant Part UsedNR
ExtractNR
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneNR
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/mlBactec: 50 µg/ml, 7H11 agar: 50 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedVoacangine
PubChem ID   73255
Ethnomedicinal InformationAntimycobacterial
PubMed ID [Source Literature]9626931
Extract PreparationThe dried powdered material was moistened with 25 % NH4OH, and extracted by chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH4OH, and extracted with chloroform. The organic phase was washed with water, and dried over Na2SO4. The organic extracts were evaporated and subjected to chromatography on silica gel
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Indole, Alkaloid, Ether
Media / Broth Used [Antimicrobial Assay/Test]Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium
Cytotoxicity Assay [AID]NR
Molecular Weight368.210
Molecular FormulaC22H28N2O3
SMILESO(C(=O)[C@]12[C@H]3N(C[C@H](C1)C[C@@H]3CC)CCc1c2[nH]c2c1cc(OC)cc2)C
XLogP3.286
PSA54.560
H-bond Donor1
H-bond Acceptor5
No. of Rotatable Bond Count4
No. of Rings3
No. of N2
No. of O3
No. of S0
Reference(s)1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73

CuratorVikramjitmandal, rachanake

                  Record - 3 of 3   [TOP]
Compound ID3382
Compound Structure
DOWNLOAD:
Plant SourceTabernaemontana citrifolia     Common Name:NR
Source FamilyApocynaceae
OriginGuadeloupe
Plant Part UsedNR
ExtractNR
Target BacteriaMycobacterium avium 733
Assay / Test DoneNR
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/mlBactec: 50 µg/ml, 7H11 agar: > 200 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedVoacangine
PubChem ID   73255
Ethnomedicinal InformationAntimycobacterial
PubMed ID [Source Literature]9626931
Extract PreparationThe dried powdered material was moistened with 25 % NH4OH, and extracted by chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH4OH, and extracted with chloroform. The organic phase was washed with water, and dried over Na2SO4. The organic extracts were evaporated and subjected to chromatography on silica gel
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Indole, Alkaloid, Ether
Media / Broth Used [Antimicrobial Assay/Test]Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium
Cytotoxicity Assay [AID]NR
Molecular Weight368.210
Molecular FormulaC22H28N2O3
SMILESO(C(=O)[C@]12[C@H]3N(C[C@H](C1)C[C@@H]3CC)CCc1c2[nH]c2c1cc(OC)cc2)C
XLogP3.286
PSA54.560
H-bond Donor1
H-bond Acceptor5
No. of Rotatable Bond Count4
No. of Rings3
No. of N2
No. of O3
No. of S0
Reference(s)1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73

CuratorVikramjitmandal, rachanake


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