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                  Page - 1 of 1                  Record - 1 of 4   [TOP]
Compound ID2747
Compound Structure
DOWNLOAD:
Plant SourceTriclisia patens     Common Name:
Source FamilyMenispermaceae
OriginMexico
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Isoniazid (0.06 µg/ml), Ethambutol (2 µg/ml), Rifampin (0.06 µg/ml), Streptomycin (0.50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml25 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedPhaeanthine
PubChem ID   73664
Ethnomedicinal InformationDropsy, swellings, oedema, gout, leprosy, malnutrition, debility, pain - killers, paralysis, epilepsy, convulsions, spasm, pulmonary troubles, sedatives
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Polycyclic, Quinoline, Alkaloid, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight622.304
Molecular FormulaC38H42N2O6
SMILESO1c2c3[C@H](N(CCc3cc(OC)c2OC)C)Cc2cc(Oc3ccc(C[C@H]4N(CCc5c4cc1c(OC)c5)C)cc3)c(OC)cc2
XLogP6.098
PSA61.860
H-bond Donor0
H-bond Acceptor8
No. of Rotatable Bond Count4
No. of Rings6
No. of N2
No. of O6
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://plants.jstor.org/upwta/4_253

Curator

                  Record - 2 of 4   [TOP]
Compound ID2748
Compound Structure
DOWNLOAD:
Plant SourceTriclisia patens     Common Name:
Source FamilyMenispermaceae
OriginMexico
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis (345)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (3.125 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedPhaeanthine
PubChem ID   73664
Ethnomedicinal InformationDropsy, swellings, oedema, gout, leprosy, malnutrition, debility, pain - killers, paralysis, epilepsy, convulsions, spasm, pulmonary troubles, sedatives
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Polycyclic, Quinoline, Alkaloid, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight622.304
Molecular FormulaC38H42N2O6
SMILESO1c2c3[C@H](N(CCc3cc(OC)c2OC)C)Cc2cc(Oc3ccc(C[C@H]4N(CCc5c4cc1c(OC)c5)C)cc3)c(OC)cc2
XLogP6.098
PSA61.860
H-bond Donor0
H-bond Acceptor8
No. of Rotatable Bond Count4
No. of Rings6
No. of N2
No. of O6
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://plants.jstor.org/upwta/4_253

Curator

                  Record - 3 of 4   [TOP]
Compound ID2749
Compound Structure
DOWNLOAD:
Plant SourceTriclisia patens     Common Name:
Source FamilyMenispermaceae
OriginMexico
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis (M12)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (12.50 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedPhaeanthine
PubChem ID   73664
Ethnomedicinal InformationDropsy, swellings, oedema, gout, leprosy, malnutrition, debility, pain - killers, paralysis, epilepsy, convulsions, spasm, pulmonary troubles, sedatives
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Polycyclic, Quinoline, Alkaloid, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight622.304
Molecular FormulaC38H42N2O6
SMILESO1c2c3[C@H](N(CCc3cc(OC)c2OC)C)Cc2cc(Oc3ccc(C[C@H]4N(CCc5c4cc1c(OC)c5)C)cc3)c(OC)cc2
XLogP6.098
PSA61.860
H-bond Donor0
H-bond Acceptor8
No. of Rotatable Bond Count4
No. of Rings6
No. of N2
No. of O6
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://plants.jstor.org/upwta/4_253

Curator

                  Record - 4 of 4   [TOP]
Compound ID2750
Compound Structure
DOWNLOAD:
Plant SourceTriclisia patens     Common Name:
Source FamilyMenispermaceae
OriginMexico
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis (M20)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (25 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedPhaeanthine
PubChem ID   73664
Ethnomedicinal InformationDropsy, swellings, oedema, gout, leprosy, malnutrition, debility, pain - killers, paralysis, epilepsy, convulsions, spasm, pulmonary troubles, sedatives
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Polycyclic, Quinoline, Alkaloid, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight622.304
Molecular FormulaC38H42N2O6
SMILESO1c2c3[C@H](N(CCc3cc(OC)c2OC)C)Cc2cc(Oc3ccc(C[C@H]4N(CCc5c4cc1c(OC)c5)C)cc3)c(OC)cc2
XLogP6.098
PSA61.860
H-bond Donor0
H-bond Acceptor8
No. of Rotatable Bond Count4
No. of Rings6
No. of N2
No. of O6
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://plants.jstor.org/upwta/4_253

Curator


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