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                  Page - 1 of 1                  Record - 1 of 6   [TOP]
Compound ID2305
Compound Structure
Plant SourcePelargonium reniforme     Common Name:
Source FamilyGeraniaceae
OriginAfrica
Plant Part UsedTuber
ExtractN - hexane
Target BacteriaMycobacterium aurum, Mycobacterium smegmatis, Mycobacterium fortuitum, Mycobacterium abscessus, Mycobacterium phlei
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem IDNR
Ethnomedicinal InformationTuberculosis, coughs
PubMed ID [Source Literature]15194133
Extract PreparationN/A
Chemical Classification [Active Compound]N/A
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Reference(s)1) Seidel V, Taylor PW. In vitro activity of extracts and constituents of Pelagonium against rapidly growing mycobacteria. Int J Antimicrob Agents. 2004, Jun;23(6):613-9

Curator

                  Record - 2 of 6   [TOP]
Compound ID2307
Compound Structure
Plant SourcePelargonium sidoides     Common Name:African Geranium
Source FamilyGeraniaceae
OriginAfrica
Plant Part UsedTuber
ExtractUnsaturated fatty acids
Target BacteriaMycobacterium aurum, Mycobacterium smegmatis, Mycobacterium fortuitum, Mycobacterium abscessus, Mycobacterium phlei
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem IDNR
Ethnomedicinal InformationTuberculosis, coughs
PubMed ID [Source Literature]15194133
Extract PreparationN/A
Chemical Classification [Active Compound]N/A
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Reference(s)1) Seidel V, Taylor PW. In vitro activity of extracts and constituents of Pelagonium against rapidly growing mycobacteria. Int J Antimicrob Agents. 2004, Jun;23(6):613-9

Curator

                  Record - 3 of 6   [TOP]
Compound ID3048
Compound Structure
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Plant SourcePeucedanum osthruthin Koch     Common Name:
Source FamilyApiaceae (Umbelliferae)
Origin
Plant Part UsedRoot
ExtractDichloromethane
Target BacteriaMycobacterium abscessus (ATCC 19 977)
Assay / Test Done
Positive Control Used (conc.)NR
Inhibition [%]
Activity [MIC] µg/ml32 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedOstruthin
PubChem ID   5281420
Ethnomedicinal Information
PubMed ID [Source Literature]12709907
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Bicyclic, Coumarin, Prenylated, Phenol
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight298.157
Molecular FormulaC19H22O3
SMILESO1c2c(cc(C/C=C(/CCC=C(C)C)C)c(O)c2)ccc1=O
XLogP5.348
PSA37.300
H-bond Donor1
H-bond Acceptor2
No. of Rotatable Bond Count5
No. of Rings2
No. of N0
No. of O3
No. of S0
Reference(s)1) Schinkovitz A, Gibbons S, Stavri M, Cocksedge MJ, Bucar F.Ostruthin: an antimycobacterial coumarin from the Roots of Peucedanum ostruthium. Planta Med. 2003 Apr;69(4):369-7

Curator

                  Record - 4 of 6   [TOP]
Compound ID3566
Compound Structure
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Plant SourceCryptolepis sanguinolenta     Common Name:Nibima
Source FamilyApocynaceae
OriginWest Africa
Plant Part UsedRoot
ExtractAmmonia moistened chloroform
Target BacteriaMycobacterium abscessus
Assay / Test DoneMTT Assay
Positive Control Used (conc.)Ethambutol (128 µg/ml), Isoniazid (32 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml32 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedCryptolepine hydrochloride
PubChem ID   156093
Ethnomedicinal InformationAntimycobacterial, antimalarial
PubMed ID [Source Literature]12722159
Extract PreparationCryptolepine was isolated from Cryptolepis sanguinolenta roots and crystallized as the hydrochloride salt
Chemical Classification [Active Compound]Aromatic, Quinoline, Alkaloid, Indole
Media / Broth Used [Antimicrobial Assay/Test]Mueller - Hinton broth, Colombia blood agar, 7H9 Middle Brook medium
Cytotoxicity Assay [AID]NR
Molecular Weight232.100
Molecular FormulaC16H13ClN2
SMILESCl.n1(c2c(nc3c2cccc3)cc2c1cccc2)C
XLogP4.596
PSA15.600
H-bond Donor0
H-bond Acceptor1
No. of Rotatable Bond Count0
No. of Rings4
No. of N2
No. of O0
No. of S0
Reference(s)1) Gibbons S, Fallah F, Wright CW.Cryptolepine hydrochloride: a potent antimycobacterial alkaloid derived from Cryptolepis sanguinolenta.Phytother Res. 2003 Apr;17(4):434-6

CuratorWvarsha, rachanake

                  Record - 5 of 6   [TOP]
Compound ID3711
Compound Structure
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Plant SourceAnethum graveolens L.     Common Name:NR
Source FamilyApiaceae (Umbelliferae)
OriginNR
Plant Part UsedWhole plant
ExtractHexane
Target BacteriaMycobacterium abscessus (ATCC 19977)
Assay / Test DoneColumbia Blood Agar
Positive Control Used (conc.)Ethambutol (128 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml2 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedFalcarindiol
PubChem ID   6436239
Ethnomedicinal InformationNR
PubMed ID [Source Literature]16317649
Extract PreparationNR
Chemical Classification [Active Compound]Aliphatic, Alkene, Alkyne, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]NR
Cytotoxicity Assay [AID]NR
Molecular Weight260.178
Molecular FormulaC17H24O2
SMILESO[C@@H](/C=CCCCCCCC)C#CC#C[C@@H](O)C=C
XLogP4.573
PSA40.460
H-bond Donor2
H-bond Acceptor2
No. of Rotatable Bond Count8
No. of Rings0
No. of N0
No. of O2
No. of S0
Reference(s)1) Stavri M, Gibbons S.The antimycobacterial constituents of dill (Anethum graveolens).Phytother Res. 2005 Nov;19(11):938-41

CuratorNajiya-beegum, vikramjitmandal

                  Record - 6 of 6   [TOP]
Compound ID4148
Compound Structure
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Plant SourceAnethum graveolens     Common Name:
Source FamilyApiaceae (Umbelliferae)
Origin
Plant Part Used
Extract
Target BacteriaMycobacterium fortuitum ATCC 6841, Mycobacterium smegmatis ATCC 14468, Mycobacterium phlei ATCC 11758, Mycobacterium aurum Pasteur Institute 104482, Mycobacterium abscessus ATCC 19977
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml2-4 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedNPMC3
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]
Extract Preparation
Chemical Classification [Active Compound]Aliphatic, Alkene, Alkyne, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight260.178
Molecular FormulaC17H24O2
SMILESO[C@H](C#CC#C[C@H](O)/C=C/CCCCCCC)C=C
XLogP4.573
PSA40.460
H-bond Donor2
H-bond Acceptor2
No. of Rotatable Bond Count8
No. of Rings0
No. of N0
No. of O2
No. of S0
Reference(s)1) In silico Comparison of Antimycobacterial Natural Products with Known Antituberculosis Drugs. Marlene Espinoza-Moraga, Nicholas M. Njuguna, Grace Mugumbate, Julio Caballero, and Kelly Chibale. Journal of Chemical Information and Modeling 2013 53 (3), 649-660

2) Rogoza, L. N.; Salakhutdinov, N. F.; Tolstikov, G. A. Anti-tubercular Activity of Natural Products: Recent Developments. In Opportunity, Challenge and Scope of Natural Products in Medicinal Chemistry; Tiwari, V. K. Ed.; Research Signpost: India, 2011; pp 103-120

Curator


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