BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 5 Record - 1 of 111 [TOP]

Compound ID	1036
Compound Structure
Plant Source	Achyranthus aspera Linn. Common Name:Prickly Chaff Flower (English), Apaamaarga (Sanskrit)
Source Family	Amaranthaceae
Origin	India
Plant Part Used	Fruit, whole plant
Extract	Methanol
Target Bacteria	Mycobacterium avium
Assay / Test Done	Micro Broth Dilution Method
Positive Control Used (conc.)	Streptomycin (IC50 value 1.14)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Leprosy, bronchitis, expectorant, asthma, cough, pulmonary infections, skin diseases
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67
Curator

Record - 2 of 111 [TOP]

Compound ID

1103

Compound Structure

Plant Source

Allium sativum L. Common Name:Garlic (English), Lashuna (Sanskrit)

Source Family

Amaryllidaceae

Origin

India, Africa, Malaysia

Plant Part Used

Bulb

Extract

Water

Target Bacteria

Mycobacterium avium

Assay / Test Done

Agar - Dilution Test

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

3130 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Allicin

PubChem ID

65036

Ethnomedicinal Information

Bronchitis, asthma, expectorant, cough, pulmonary phthisis, consumption, chronic diseases of lungs, whooping cough, laryngeal tuberculosis

PubMed ID [Source Literature]

4004189

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aliphatic, Alkene, Disulfide

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

162.017

Molecular Formula

C₆H₁₀OS₂

SMILES

S(=O)(SCC=C)CC=C

XLogP

0.237

PSA

61.580

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Delaha EC, Garagusi VF.Inhibition of mycobacteria by garlic extract (Allium sativum).Antimicrob Agents Chemother. 1985 Apr;27(4):485-6

Curator

Record - 3 of 111 [TOP]

Compound ID	1119
Compound Structure
Plant Source	Allium sativum L. Common Name:Garlic (English), Lashuna (Sanskrit)
Source Family	Amaryllidaceae
Origin	India, Africa, Malaysia
Plant Part Used	Bulb
Extract	Methanol
Target Bacteria	Mycobacterium avium
Assay / Test Done	Micro Broth Dilution Method
Positive Control Used (conc.)	Streptomycin (IC50 value 1.14)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Bronchitis, asthma, expectorant, cough, pulmonary phthisis, consumption, chronic diseases of lungs, whooping cough, laryngeal tuberculosis
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67
Curator

Record - 4 of 111 [TOP]

Compound ID	1145
Compound Structure
Plant Source	Alnus rubra Bong Common Name:Red Alder
Source Family	Betulaceae
Origin	British Columbia
Plant Part Used	Bark, Catkin
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis, Mycobacterium avium
Assay / Test Done	Disk Diffusion Assay
Positive Control Used (conc.)	Isoniazid
Inhibition [%]	100 %
Activity [MIC] µg/ml	50 µg extract/Disc
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Bark is an appetizer, astringent, cathartic, cytostatic, emetic, stomachic and tonic, useful in treatment of headaches, rheumatic pains, internal injuries and diarrhoea
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) A.R. McCutcheon, R.W. Stokes, L.M. Thorson, S.M. Ellis, R.E.W. Hancock and G.H.N. Towers.Anti-Mycobacterial Screening of British Columbian Medicinal Plants.Pharmaceutical Biology, 1997, Vol. 35, No. 2 , Pages 77-83 2) http://www.pfaf.org/user/Plant.aspx?LatinName=Alnus%20rubra
Curator

Record - 5 of 111 [TOP]

Compound ID	1201
Compound Structure
Plant Source	Apium graveolens L. Common Name:Celery (English), Ajmodaa, Ajmoda, Ajmodikaa, Dipyaka (Sanskrit)
Source Family	Apiaceae (Umbelliferae)
Origin	India, Malaysia, Worldwide
Plant Part Used	Seed
Extract	Methanol
Target Bacteria	Mycobacterium avium
Assay / Test Done	Micro Broth Dilution Method
Positive Control Used (conc.)	Streptomycin (IC50 value 1.14)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)	1:40 dilutions
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Bronchitis, asthma, chest pain, cough, anthelmintic, antifungal, fever, urinary calculi, obesity, musculoskeletal disorder, dropsy, chronic diarrhoea
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34 2) http://parisaramahiti.kar.nic.in/Medicinal_plants_new/med%20plants/p18.html
Curator

Record - 6 of 111 [TOP]

Compound ID	1229
Compound Structure
Plant Source	Azadirachta indica A.juss. Common Name:Neem Tree, Margosa Tree (English), Nimba, Nimbaka (Sanskrit)
Source Family	Meliaceae
Origin	India, Kenya
Plant Part Used	Leaf
Extract	Methanol
Target Bacteria	Mycobacterium avium
Assay / Test Done	Micro Broth Dilution Method
Positive Control Used (conc.)	Streptomycin (IC50 value 1.14)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Cough, asthma, consumption, phthisis, tuberculosis, anthelmintic, antiseptic. Used to treat chronic leprosy, skin diseases, intestinal worms, chronic malaria fevers, small pox, syphylictic sores
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67 2) Rao, R.R.Ethnobotanical studies on the flora of Meghalaya -- Some interesting reports of herbal medicines.1981, S.K. Jain (Ed.), 137-148
Curator

Record - 7 of 111 [TOP]

Compound ID	1284
Compound Structure
Plant Source	Borrichia frutescens L. Common Name:Sea Daisy
Source Family	Asteraceae (Compositae)
Origin	USA
Plant Part Used	Flower
Extract	Dichloromethane
Target Bacteria	Mycobacterium avium
Assay / Test Done
Positive Control Used (conc.)	Rifampin, Clarithromycin
Inhibition [%]	99 %
Activity [MIC] µg/ml	1000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	23195767
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) C.L. Cantrell, N.H. Fischer, L. Urbatsch, M.S. McGuire, S.G. Franzblau.Antimycobacterial crude plant extracts from South, Central, and North America.Phytomedicine, Volume 5, Issue 2, April 1998, Pages 137–145
Curator

Record - 8 of 111 [TOP]

Compound ID

1303

Compound Structure

Plant Source

Buddleja saligna L. Common Name:Squarestem Butterflybush

Source Family

Buddlejaceae

Origin

Africa

Plant Part Used

Leaf, stem

Extract

Hexane

Target Bacteria

Mycobacterium avium (ATCC 25291)

Assay / Test Done

Bioautography on TLC plates

Positive Control Used (conc.)

Rifampin (2.5 µg/spot)

Inhibition [%]

Activity [MIC] µg/ml

1.25 µg/spot

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Oleanolic acid

PubChem ID

10494

Ethnomedicinal Information

Tuberculosis symptoms

PubMed ID [Source Literature]

18384988

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Pentacyclic, Terpene, Triterpene, Acid, Alcohol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

456.360

Molecular Formula

C₃₀H₄₈O₃

SMILES

O[C@@H]1C([C@H]2[C@@]([C@@H]3[C@]([C@]4(C(=CC3)[C@H]3[C@@](CC4)(CCC(C3)(C)C)C(=O)O)C)(CC2)C)(CC1)C)(C)C

XLogP

9.052

PSA

57.530

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Bamuamba K, Gammon DW, Meyers P, Dijoux-Franca MG, Scott G.Anti-mycobacterial activity of five plant species used as traditional medicines in the Western Cape Province (South Africa).J Ethnopharmacol. 2008 May 8;117(2):385-90

Curator

Record - 9 of 111 [TOP]

Compound ID	1410
Compound Structure
Plant Source	Centella asiatica (L.) Urban Common Name:Asiatic Pennywort, Indian Pennywort (English), Mandukaparni, Mandukaparnikaa (Sanskrit)
Source Family	Apiaceae (Umbelliferae)
Origin	Malaysia, India
Plant Part Used	Whole plant
Extract	Methanol
Target Bacteria	Mycobacterium avium
Assay / Test Done	Micro Broth Dilution Method
Positive Control Used (conc.)	Streptomycin (IC50 value 1.14)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Asthma, treatment of leprosy and skin diseases
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67 2) http://www.himalayahealthcare.com/herbfinder/h_centel.htm
Curator

Record - 10 of 111 [TOP]

Compound ID	1450
Compound Structure
Plant Source	Cinnamomum zeylandicum Breyn. Common Name:Cinnamon, Ceylon Cinnamon (English), Tvak, Daaruchini (Sanskrit)
Source Family	Lauraceae
Origin	Sri Lanka, Sumatra, Eastern Islands, Brazil, Mauritius, India, Jamaica
Plant Part Used	Bark
Extract	Methanol (9.41 %)
Target Bacteria	Mycobacterium avium
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Streptomycin (IC50 value 1.14)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Antiseptic and used to treat gonorrhoea, asthma, diabetes, diseases of oral cavity, bronchitis, expectorant
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67
Curator

Record - 11 of 111 [TOP]

Compound ID	1525
Compound Structure
Plant Source	Commiphora mukul Engl. Common Name:Indian Bdellium tree (English), Guggulu (Sanskrit)
Source Family	Rutaceae
Origin	India
Plant Part Used	Resin
Extract	Methanol
Target Bacteria	Mycobacterium avium
Assay / Test Done	Micro Broth Dilution Method
Positive Control Used (conc.)	Streptomycin (IC50 value 1.14)
Inhibition [%]
Activity [MIC] µg/ml	62.5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculous glands of neck, asthma, troubles of chest, expectorant, bronchitis, whooping cough, pulmonary tuberculosis
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67 2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India
Curator

Record - 12 of 111 [TOP]

Compound ID	1534
Compound Structure
Plant Source	Coptis teeta Wall. Common Name:Gold Thread (English), Mamira, Maamiraa, Tiktamuulaa (Sanskrit)
Source Family	Ranunculaceae
Origin	India
Plant Part Used	Root
Extract	Water
Target Bacteria	Mycobacterium avium
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Cough
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34
Curator

Record - 13 of 111 [TOP]

Compound ID	1627
Compound Structure
Plant Source	Empetrum nigrum L. Common Name:Black Crowberry
Source Family	Empetraceae
Origin	British Columbia
Plant Part Used	Stem
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis, Mycobacterium avium
Assay / Test Done	Disk Diffusion Assay
Positive Control Used (conc.)	Isoniazid
Inhibition [%]	100 %
Activity [MIC] µg/ml	50 µg extract/Disc
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Fever, used as a diuretic, kidney problems, diarrhoea, colds
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) A.R. McCutcheon, R.W. Stokes, L.M. Thorson, S.M. Ellis, R.E.W. Hancock and G.H.N. Towers.Anti-Mycobacterial Screening of British Columbian Medicinal Plants.Pharmaceutical Biology, 1997, Vol. 35, No. 2 , Pages 77-83
Curator

Record - 14 of 111 [TOP]

Compound ID	1628
Compound Structure
Plant Source	Entada abyssinica A. Rich Common Name:Tree Entanda
Source Family	Fabaceae
Origin	Kenya
Plant Part Used	Stem
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis, Mycobacterium avium, Mycobacterium intracellulare, Mycobacterium chelonae / chelonei, Mycobacterium terrae
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]	10 % of the inoculum of the five mycobacterial species at 2 mg/ml
Activity [MIC] µg/ml	0.5 - 4 mg/ml based on bacteria
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	9533435
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Fabry W, Okemo PO, Ansorg R.Antibacterial activity of East African medicinal plants.J Ethnopharmacol. 1998 Feb;60(1):79-84
Curator

Record - 15 of 111 [TOP]

Compound ID	1631
Compound Structure
Plant Source	Equisetum arvense L. Common Name:Field Horsetail (English), Ashwa - Puchha (Sanskrit)
Source Family	Equisetaceae
Origin	India, Britain and Northern temperate region
Plant Part Used	Leaf
Extract	Methanol
Target Bacteria	Mycobacterium avium
Assay / Test Done	Micro Broth Dilution Method
Positive Control Used (conc.)	Streptomycin (IC50 value 1.14 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Recommended and effective in treatment of tuberculosis by older herbalists. Proved very effectual in spitting of blood.
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67
Curator

Record - 16 of 111 [TOP]

Compound ID	1641
Compound Structure
Plant Source	Erigeron strigosus Muhl Common Name:Daisy Fleabane, Prairie Fleabane, Rough Fleabane
Source Family	Asteraceae (Compositae)
Origin	USA
Plant Part Used	Root
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis, Mycobacterium avium
Assay / Test Done
Positive Control Used (conc.)	Rifampin, Clarithromycin
Inhibition [%]	100 %
Activity [MIC] µg/ml	100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	23195767
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) C.L. Cantrell, N.H. Fischer, L. Urbatsch, M.S. McGuire, S.G. Franzblau.Antimycobacterial crude plant extracts from South, Central, and North America.Phytomedicine, Volume 5, Issue 2, April 1998, Pages 137–145
Curator

Record - 17 of 111 [TOP]

Compound ID	1663
Compound Structure
Plant Source	Eucalyptus globulus Labill Common Name:Blue Gum Tree (English), Tilaparna, Tailaparna, Sugandhapatra (Sanskrit)
Source Family	Myrtaceae
Origin	Brazil, Tasmania, Australia, South Europe
Plant Part Used	Leaf
Extract	Essential oil
Target Bacteria	MDR Mycobacterium tuberculosis, Mycobacterium tuberculosis, Mycobacterium avium
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	0.01 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Antiseptic, expectorant, stimulant, febrifuge and used to treat cough, respiratory disorders
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Moreira, Raquel R. D; Anno, Ivone S; Leite, Clarice Q. F.Sensitivity of mycobacteria to different species of Eucalyptus L herit.Rev. microbiol;28(4):256-60
Curator

Record - 18 of 111 [TOP]

Compound ID	1722
Compound Structure
Plant Source	Euthamia leptocephala Greene Common Name:Bushy Goldentop
Source Family	Asteraceae (Compositae)
Origin	USA
Plant Part Used	Aerial
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis, Mycobacterium avium
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]	100 %
Activity [MIC] µg/ml	1000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	23195767
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) C.L. Cantrell, N.H. Fischer, L. Urbatsch, M.S. McGuire, S.G. Franzblau.Antimycobacterial crude plant extracts from South, Central, and North America.Phytomedicine, Volume 5, Issue 2, April 1998, Pages 137–145
Curator

Record - 19 of 111 [TOP]

Compound ID	1808
Compound Structure
Plant Source	Glehnia littoris F. Schmidt ssp Leiocarpa (Mathias) Hult. Common Name:Beach Silvertop, American Silvertop
Source Family	Apiaceae (Umbelliferae)
Origin	British Columbia
Plant Part Used	Root
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis, Mycobacterium avium
Assay / Test Done	Disk Diffusion Assay
Positive Control Used (conc.)	Isoniazid
Inhibition [%]	100 %
Activity [MIC] µg/ml	50 µg extract/Disc
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Cough
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) A.R. McCutcheon, R.W. Stokes, L.M. Thorson, S.M. Ellis, R.E.W. Hancock and G.H.N. Towers.Anti-Mycobacterial Screening of British Columbian Medicinal Plants.Pharmaceutical Biology, 1997, Vol. 35, No. 2 , Pages 77-83 2) http://netartsbaytoday.org/html/white_flowers.html
Curator

Record - 20 of 111 [TOP]

Compound ID	1816
Compound Structure
Plant Source	Glycyrrhiza glabra L. Common Name:Licorice, Liquorice (English), Yashtimadhu (Sanskrit)
Source Family	Fabaceae
Origin	India, Africa
Plant Part Used	Root
Extract	Methanol
Target Bacteria	Mycobacterium avium
Assay / Test Done	Micro Broth Dilution Method
Positive Control Used (conc.)	Streptomycin (IC50 value 1.14)
Inhibition [%]
Activity [MIC] µg/ml	250 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Expectorant, consumption, bronchitis, chest complaint, cough
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34
Curator

Record - 21 of 111 [TOP]

Compound ID	1843
Compound Structure
Plant Source	Harrisonia abyssinica Oliv Common Name:
Source Family	Simaroubaceae
Origin	Kenya
Plant Part Used	Root
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis, Mycobacterium avium, Mycobacterium intracellulare, Mycobacterium chelonae / chelonei, Mycobacterium terrae
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	9533435
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Fabry W, Okemo PO, Ansorg R.Antibacterial activity of East African medicinal plants.J Ethnopharmacol. 1998 Feb;60(1):79-84
Curator

Record - 22 of 111 [TOP]

Compound ID	1863
Compound Structure
Plant Source	Heracleum maximum Bartr. Common Name:Common Cowparsnip
Source Family	Apiaceae (Umbelliferae)
Origin	British Columbia
Plant Part Used	Root
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis, Mycobacterium avium
Assay / Test Done	Disk Diffusion Assay
Positive Control Used (conc.)	Isoniazid
Inhibition [%]	100 %
Activity [MIC] µg/ml	50 µg extract/Disc
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Colic, cramps, headaches, sore throats, colds, coughs and flu, poultices used for sores, bruises, swelling, rheumatic joints and boils or other skin eruptions
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) A.R. McCutcheon, R.W. Stokes, L.M. Thorson, S.M. Ellis, R.E.W. Hancock and G.H.N. Towers.Anti-Mycobacterial Screening of British Columbian Medicinal Plants.Pharmaceutical Biology, 1997, Vol. 35, No. 2 , Pages 77-83 2) http://www.ionxchange.com/products/HERACLEUM-MAXIMUM-\|-Cow-Parnsip.html
Curator

Record - 23 of 111 [TOP]

Compound ID

1878

Compound Structure

Plant Source

Hydrastis canadensis Common Name:Goldenseal

Source Family

Ranunculaceae

Origin

North America

Plant Part Used

Root

Extract

Ethanol

Target Bacteria

Mycobacterium avium complex

Assay / Test Done

Positive Control Used (conc.)

Streptomycin sulfate (6.25 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

50 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Berberine

PubChem ID

2353

Ethnomedicinal Information

Berberine has been demonstrated to reduce the infectivity of bacteria, fungi and protozoa in animals and humans by inhibiting the adherence of microorganisms to the host cells

PubMed ID [Source Literature]

9784149, 4906191

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Alkaloid, Isoquinoline, Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

336.124

Molecular Formula

C₂₀H₁₈NO₄

SMILES

O1c2cc3CC[n+]4c(c3cc2OC1)cc1c(c4)c(OC)c(OC)cc1

XLogP

2.896

PSA

40.800

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Gentry EJ, Jampani HB, Keshavarz-Shokri A, Morton MD, Velde DV, Telikepalli H, Mitscher LA, Shawar R, Humble D, Baker W.Antitubercular natural products: berberine from the roots of commercial Hydrastis canadensis powder. Isolation of inactive 8-oxotetrahydrothalifendine, canadine, beta-hydrastine, and two new quinic acid esters, hycandinic acid esters-1 and -2.J Nat Prod. 1998 Oct;61(10):1187-93

2) Amin AH, Subbaiah TV, Abbasi KM.Berberine sulfate: antimicrobial activity, bioassay, and mode of action.Can J Microbiol. 1969 Sep;15(9):1067-76

Curator

Record - 24 of 111 [TOP]

Compound ID	1893
Compound Structure
Plant Source	Hypericum perforatum L. Common Name:Common St. John's Wort (English)
Source Family	Hypericaceae
Origin	India, British Columbia
Plant Part Used	Whole plant
Extract	Methanol
Target Bacteria	Mycobacterium avium
Assay / Test Done	Disk Diffusion Assay
Positive Control Used (conc.)	Isoniazid (10 µl of 10 mg/ml)
Inhibition [%]
Activity [MIC] µg/ml	10 µg extract/Disc
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Wound healing, antiseptic and disinfectant qualities,cough, expectorant, chronic catarrh of lungs
PubMed ID [Source Literature]	1453710
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) McCutcheon AR, Ellis SM, Hancock RE, Towers GH.Antibiotic screening of medicinal plants of the British Columbian native peoples.J Ethnopharmacol. 1992 Oct;37(3):213-23
Curator

Record - 25 of 111 [TOP]

Compound ID	1925
Compound Structure
Plant Source	Inula racemosa Hook. f. syn. Inula helenium L. Common Name:Elecampane (English), Pushkaramula, Pushkara, Paushkara, Padmapatra, Kaashmira, Kushtha - bheda (Sanskrit)
Source Family	Asteraceae (Compositae)
Origin	India
Plant Part Used	Root
Extract	Methanol
Target Bacteria	Mycobacterium avium, Mycobacterium smegmatis
Assay / Test Done	Micro Broth Dilution Method
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis, lung disorders, cough, expectorant, random screening, bronchitis
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67
Curator

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