BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 9 [TOP]

Compound ID

1105

Compound Structure

Plant Source

Allium sativum L. Common Name:Garlic (English), Lashuna (Sanskrit)

Source Family

Amaryllidaceae

Origin

India, Africa, Malaysia

Plant Part Used

Bulb

Extract

Water

Target Bacteria

Mycobacterium chelonae

Assay / Test Done

Agar - Dilution Test

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

2000 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Allicin

PubChem ID

65036

Ethnomedicinal Information

Bronchitis, asthma, expectorant, cough, pulmonary phthisis, consumption, chronic diseases of lungs, whooping cough, laryngeal tuberculosis

PubMed ID [Source Literature]

4004189

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aliphatic, Alkene, Disulfide

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

162.017

Molecular Formula

C₆H₁₀OS₂

SMILES

S(=O)(SCC=C)CC=C

XLogP

0.237

PSA

61.580

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Delaha EC, Garagusi VF.Inhibition of mycobacteria by garlic extract (Allium sativum).Antimicrob Agents Chemother. 1985 Apr;27(4):485-6

Curator

Record - 2 of 9 [TOP]

Compound ID	1231
Compound Structure
Plant Source	Azadirachta indica A.juss. Common Name:Neem Tree, Margosa Tree (English), Nimba, Nimbaka (Sanskrit)
Source Family	Meliaceae
Origin	India, Kenya
Plant Part Used	Stem bark
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis, Mycobacterium avian, Mycobacterium chelonae, Mycobacterium intracellulare, Mycobacterium tarrae
Assay / Test Done	Broth Dilution Assay
Positive Control Used (conc.)
Inhibition [%]	10 %
Activity [MIC] µg/ml	8000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Cough, asthma, consumption, phthisis, tuberculosis, anthelmintic, antiseptic. Used to treat chronic leprosy, skin diseases, intestinal worms, chronic malaria fevers, small pox, syphylictic sores
PubMed ID [Source Literature]	9533435
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Fabry W, Okemo PO, Ansorg R.Antibacterial activity of East African medicinal plants.J Ethnopharmacol. 1998 Feb;60(1):79-84
Curator

Record - 3 of 9 [TOP]

Compound ID	1628
Compound Structure
Plant Source	Entada abyssinica A. Rich Common Name:Tree Entanda
Source Family	Fabaceae
Origin	Kenya
Plant Part Used	Stem
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis, Mycobacterium avium, Mycobacterium intracellulare, Mycobacterium chelonae / chelonei, Mycobacterium terrae
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]	10 % of the inoculum of the five mycobacterial species at 2 mg/ml
Activity [MIC] µg/ml	0.5 - 4 mg/ml based on bacteria
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	9533435
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Fabry W, Okemo PO, Ansorg R.Antibacterial activity of East African medicinal plants.J Ethnopharmacol. 1998 Feb;60(1):79-84
Curator

Record - 4 of 9 [TOP]

Compound ID	1843
Compound Structure
Plant Source	Harrisonia abyssinica Oliv Common Name:
Source Family	Simaroubaceae
Origin	Kenya
Plant Part Used	Root
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis, Mycobacterium avium, Mycobacterium intracellulare, Mycobacterium chelonae / chelonei, Mycobacterium terrae
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	9533435
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Fabry W, Okemo PO, Ansorg R.Antibacterial activity of East African medicinal plants.J Ethnopharmacol. 1998 Feb;60(1):79-84
Curator

Record - 5 of 9 [TOP]

Compound ID

1965

Compound Structure

Plant Source

Juniperus procera Hochst Common Name:Grecian Juniper

Source Family

Cupressaceae

Origin

India, Saudi Arabia

Plant Part Used

Leaf

Extract

Ethanol

Target Bacteria

Mycobacterium smegmatis, Mycobacterium intracellulare, Mycobacterium chelonae, Mycobacterium xenopi

Assay / Test Done

Positive Control Used (conc.)

Streptomycin (10 µg/ml), Isoniazid (10 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

5 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

(+)-Ferruginol

PubChem ID

403773

Ethnomedicinal Information

Tuberculosis

PubMed ID [Source Literature]

10925394

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Tricyclic, Terpene, Meroterpene, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

286.230

Molecular Formula

C₂₀H₃₀O

SMILES

Oc1cc2[C@@]3(C(C(CCC3)(C)C)CCc2cc1C(C)C)C

XLogP

8.211

PSA

20.230

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) I. Muhammad*, J.S. Mossa, F.S. El-Feraly.Antibacterial diterpenes from the leaves and seeds of Juniperus excelsa M. Bieb.Phytotherapy Research, Volume 6, Issue 5, pages 261–264, September/October 1992

2) Newton SM, Lau C, Wright CW.A review of antimycobacterial natural products.Phytother Res. 2000 Aug;14(5):303-22

3) http://www.pfaf.org/user/Plant.aspx?LatinName=Juniperus+excelsa

Curator

Record - 6 of 9 [TOP]

Compound ID

1968

Compound Structure

Plant Source

Juniperus procera Hochst Common Name:African Pencil Cedar, Cedar, East African Cedar, East African Pencil Cedar, Pencil Cedar

Source Family

Cupressaceae

Origin

Saudi Arabia

Plant Part Used

Bark

Extract

Chloroform

Target Bacteria

Mycobacterium intracellulare, Mycobacterium xenopi, Mycobacterium chelonae / chelonei, Mycobacterium smegmatis

Assay / Test Done

Positive Control Used (conc.)

Streptomycin (10 µg/ml), Isoniazid (10 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

2.5 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

(+)-Totarol

PubChem ID

460178

Ethnomedicinal Information

Sore throat, chew fruits

PubMed ID [Source Literature]

10925394

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Terpene, Meroterpene, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

286.230

Molecular Formula

C₂₀H₃₀O

SMILES

Oc1c(c2c([C@@]3(C(C(CCC3)(C)C)CC2)C)cc1)C(C)C

XLogP

8.211

PSA

20.230

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Newton SM, Lau C, Wright CW.A review of antimycobacterial natural products.Phytother Res. 2000 Aug;14(5):303-22

2) http://www.worldagroforestrycentre.org/sea/Products/AFDbases/af/asp/SpeciesInfo.asp?SpID=1022

Curator

Record - 7 of 9 [TOP]

Compound ID	2624
Compound Structure
Plant Source	Spilanthes mauritiana A. Rich. DC. Common Name:
Source Family	Asteraceae (Compositae)
Origin	Kenya
Plant Part Used	Root, flower
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis, Mycobacterium avium, Mycobacterium intracellulare, Mycobacterium chelonae / chelonei, Mycobacterium terrae
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]	10 % of the inoculum of the five mycobacterial species at 2 mg/ml
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	9533435
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Fabry W, Okemo PO, Ansorg R.Antibacterial activity of East African medicinal plants.J Ethnopharmacol. 1998 Feb;60(1):79-84
Curator

Record - 8 of 9 [TOP]

Compound ID	2716
Compound Structure
Plant Source	Terminalia spinosa Engl Common Name:Small - Leaved Terminalia (English), Musosahwai (Sanskrit)
Source Family	Combretaceae
Origin	Kenya
Plant Part Used	Stem
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis, Mycobacterium avium, Mycobacterium intracellulare, Mycobacterium chelonae / chelonei, Mycobacterium terrae
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]	10% of the inoculum of the five mycobacterial species at 2 mg/ml
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	9533435
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Fabry W, Okemo PO, Ansorg R.Antibacterial activity of East African medicinal plants.J Ethnopharmacol. 1998 Feb;60(1):79-84 2) http://www.zimbabweflora.co.zw/speciesdata/species.php?species_id=142190
Curator

Record - 9 of 9 [TOP]

Compound ID	2814
Compound Structure	N/A
Plant Source	Ximenia caffra Sond Common Name:Sourplum (English), Munhengeni, Mutengeni, Mutsvanzva (Sanskrit)
Source Family	Olacaceae
Origin	Kenya
Plant Part Used	Root
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis, Mycobacterium avium, Mycobacterium intracellulare, Mycobacterium chelonae / chelonei, Mycobacterium terrae
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]	10% of the inoculum of the five mycobacterial species at 2 mg/ml
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Diarrhoea and dysentery, fever, cough, venereal diseases
PubMed ID [Source Literature]	9533435
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Fabry W, Okemo PO, Ansorg R.Antibacterial activity of East African medicinal plants.J Ethnopharmacol. 1998 Feb;60(1):79-84 2) http://www.zimbabweflora.co.zw/speciesdata/species.php?species_id=121590
Curator

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