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                  Page - 1 of 1                  Record - 1 of 5   [TOP]
Compound ID1118
Compound Structure
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Plant SourceAllium sativum L.     Common Name:Garlic (English), Lashuna (Sanskrit)
Source FamilyAmaryllidaceae
OriginIndia, Africa, Malaysia
Plant Part UsedBulb
ExtractWater
Target BacteriaMycobacterium xenopi
Assay / Test DoneAgar - Dilution Test
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml2680 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedAllicin
PubChem ID   65036
Ethnomedicinal InformationBronchitis, asthma, expectorant, cough, pulmonary phthisis, consumption, chronic diseases of lungs, whooping cough, laryngeal tuberculosis
PubMed ID [Source Literature]4004189
Extract PreparationN/A
Chemical Classification [Active Compound]Aliphatic, Alkene, Disulfide
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight162.017
Molecular FormulaC6H10OS2
SMILESS(=O)(SCC=C)CC=C
XLogP0.237
PSA61.580
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count5
No. of Rings0
No. of N0
No. of O1
No. of S2
Reference(s)1) Delaha EC, Garagusi VF.Inhibition of mycobacteria by garlic extract (Allium sativum).Antimicrob Agents Chemother. 1985 Apr;27(4):485-6

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                  Record - 2 of 5   [TOP]
Compound ID1965
Compound Structure
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Plant SourceJuniperus procera Hochst     Common Name:Grecian Juniper
Source FamilyCupressaceae
OriginIndia, Saudi Arabia
Plant Part UsedLeaf
ExtractEthanol
Target BacteriaMycobacterium smegmatis, Mycobacterium intracellulare, Mycobacterium chelonae, Mycobacterium xenopi
Assay / Test Done
Positive Control Used (conc.)Streptomycin (10 µg/ml), Isoniazid (10 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified(+)-Ferruginol
PubChem ID   403773
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]10925394
Extract PreparationN/A
Chemical Classification [Active Compound]Alicyclic, Tricyclic, Terpene, Meroterpene, Phenol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight286.230
Molecular FormulaC20H30O
SMILESOc1cc2[C@@]3(C(C(CCC3)(C)C)CCc2cc1C(C)C)C
XLogP8.211
PSA20.230
H-bond Donor1
H-bond Acceptor1
No. of Rotatable Bond Count1
No. of Rings3
No. of N0
No. of O1
No. of S0
Reference(s)1) I. Muhammad*, J.S. Mossa, F.S. El-Feraly.Antibacterial diterpenes from the leaves and seeds of Juniperus excelsa M. Bieb.Phytotherapy Research, Volume 6, Issue 5, pages 261–264, September/October 1992

2) Newton SM, Lau C, Wright CW.A review of antimycobacterial natural products.Phytother Res. 2000 Aug;14(5):303-22

3) http://www.pfaf.org/user/Plant.aspx?LatinName=Juniperus+excelsa

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                  Record - 3 of 5   [TOP]
Compound ID1968
Compound Structure
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Plant SourceJuniperus procera Hochst     Common Name:African Pencil Cedar, Cedar, East African Cedar, East African Pencil Cedar, Pencil Cedar
Source FamilyCupressaceae
OriginSaudi Arabia
Plant Part UsedBark
ExtractChloroform
Target BacteriaMycobacterium intracellulare, Mycobacterium xenopi, Mycobacterium chelonae / chelonei, Mycobacterium smegmatis
Assay / Test Done
Positive Control Used (conc.)Streptomycin (10 µg/ml), Isoniazid (10 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml2.5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified(+)-Totarol
PubChem ID   460178
Ethnomedicinal InformationSore throat, chew fruits
PubMed ID [Source Literature]10925394
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tricyclic, Terpene, Meroterpene, Phenol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight286.230
Molecular FormulaC20H30O
SMILESOc1c(c2c([C@@]3(C(C(CCC3)(C)C)CC2)C)cc1)C(C)C
XLogP8.211
PSA20.230
H-bond Donor1
H-bond Acceptor1
No. of Rotatable Bond Count1
No. of Rings3
No. of N0
No. of O1
No. of S0
Reference(s)1) Newton SM, Lau C, Wright CW.A review of antimycobacterial natural products.Phytother Res. 2000 Aug;14(5):303-22

2) http://www.worldagroforestrycentre.org/sea/Products/AFDbases/af/asp/SpeciesInfo.asp?SpID=1022

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                  Record - 4 of 5   [TOP]
Compound ID3968
Compound Structure
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Plant SourceFerula communis     Common Name:Giant Fennel
Source FamilyApiaceae (Umbelliferae)
OriginSaudi Arabia
Plant Part UsedRhizome
Extract
Target BacteriaMycobacterium xenopi
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedFerchromone
PubChem IDNR
Ethnomedicinal InformationAnti-mycobacterial
PubMed ID [Source Literature]
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Tricyclic, Terpene, Sesquiterpene, Chromone, Prenylated, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight384.230
Molecular FormulaC24H32O4
SMILESC1c2c(ccc1)OC1C(C2=O)CC([C@@](O1)(CC/C=C(/CCC=C(C)C)C)C)O
XLogP5.430
PSA55.760
H-bond Donor1
H-bond Acceptor4
No. of Rotatable Bond Count6
No. of Rings3
No. of N0
No. of O4
No. of S0
Reference(s)1) Mohammed A. Al-Yahya, Ilias Muhammad, Humayun H. Mirza, Farouk S. El-Feraly.Antibacterial constituents from the rhizomes of Ferula communis.Phytotherapy Research.12/1998;12(5):335-339

2) http://www.pfaf.org/user/Plant.aspx?LatinName=Ferula+communis

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                  Record - 5 of 5   [TOP]
Compound ID3965
Compound Structure
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Plant SourceFerula communis     Common Name:Giant Fennel
Source FamilyApiaceae (Umbelliferae)
OriginSaudi Arabia
Plant Part UsedRhizome
Extract
Target BacteriaMycobacterium xenopi
Assay / Test Done
Positive Control Used (conc.)Amikacin (0.25 µg/ml), Streptomycin (10 µg/ml), Isoniazid (10 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml1.25 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedFerulenol
PubChem ID   54679300
Ethnomedicinal InformationAnti-mycobacterial
PubMed ID [Source Literature]
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Bicyclic, Alkyl, Alkene, Coumarin, Prenylated, Phenol
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight366.219
Molecular FormulaC24H30O3
SMILESO1c2c(c(O)c(C/C=C(/CC/C=C(/CCC=C(C)C)C)C)c1=O)cccc2
XLogP8.182
PSA37.300
H-bond Donor1
H-bond Acceptor2
No. of Rotatable Bond Count8
No. of Rings2
No. of N0
No. of O3
No. of S0
Reference(s)1) Mohammed A. Al-Yahya, Ilias Muhammad, Humayun H. Mirza, Farouk S. El-Feraly.Antibacterial constituents from the rhizomes of Ferula communis.Phytotherapy Research.12/1998;12(5):335-339

2) http://www.pfaf.org/user/Plant.aspx?LatinName=Ferula+communis

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