S.No.	Modification	Sequence	Source	Cell line	Inhibition/IC50	Unit	Target	Assay	Reference
1	(ac):acetyl, (b): benzyl, (K): D-lysine	(ac)T(b)YIC(b)E(b)VEDQ(K)(ac)EE(a)	V1J1 region of the CD4 molecule	CEM-SS	16	µM	Fusion inhibitor	Cytopathic effect	2078014
2	(ac):acetyl, (b): benzyl, (a): amide, (ac): acetyl	(ac)T(b)YIC(b)E(b)VEDQK(ac)EE(a)	V1J1 region of the CD4 molecule	CEM-SS	16	µM	Fusion inhibitor	Cytopathic effect	2078014
3	(w):D-Trp	(w)YDL	Synthetic	NA	12	µM	Protease inhibition	Enzyme inhibition assay	8783807
4	(w):D-Trp	(w)YEL	Synthetic	NA	27	µM	Protease inhibition	Enzyme inhibition assay	8783807
5	dimer	2x(LEAIPCSIPPEFLFGKPFVF)4	Human hemofiltrate	P4-CCR5	0.19±0.09	µM	Virus entry	ELISA	17448989
6	Ac:acetyl	Ac-EWYNQTKDLQQKFYEIIMDIEQNNVQGKKGIQQLQ-NH2	C-terminal HR2 domain of FIV gp45	CEM4/IIIb	>2.304	µM	Virus entry	Syncytial plaque-forming assay	12186891
7	Ac:acetyl	Ac-GEWYNQTKDLQQKFYEIIMDIEQNNVQGKKGIQQL-NH2	C-terminal HR2 domain of FIV gp44	CEM4/IIIb	>2.342	µM	Virus entry	Syncytial plaque-forming assay	12186891
8	Ac:acetyl	Ac-GNITLGEWYNQTKDLQQKFYEIIMDIEQNNVQG-NH2	C-terminal HR2 domain of FIV gp42	CEM4/IIIb	2.053	µM	Virus entry	Syncytial plaque-forming assay	12186891
9	Ac: acetyl	Ac-ISYNL	Synthetic	NA	70	µM	Protease inhibition	Enzyme inhibition assay	8783807
10	Ac:acetyl	Ac-ITLGEWYNQTKDLQQKFYEIIMDIEQNNVQGKKGI-NH2	C-terminal HR2 domain of FIV gp40	CEM4/IIIb	>2.365	µM	Virus entry	Syncytial plaque-forming assay	12186891
11	Ac: acetyl	Ac-LEAIPMSIPPEVKFNKPFVF	Human hemofiltrate	P4-CCR5	>100	µM	Virus entry	ELISA	17448989
12	Ac: acetyl, Am: amide	Ac-LEAIPMSIPPEVKFNKPFVF-Am	Human hemofiltrate	P4-CCR5	>100	µM	Virus entry	ELISA	17448989
13	Ac:acetyl	Ac-LGEWYNQTKDLQQKFYEIIMDIEQNNVQGKKGIQQ-NH2	C-terminal HR2 domain of FIV gp41	CEM4/IIIb	1.933	µM	Virus entry	Syncytial plaque-forming assay	12186891
14	Ac:acetyl	Ac-NITLGEWYNQTKDLQQKFYEIIMDIEQNNVQGK-NH2	C-terminal HR2 domain of FIV gp43	CEM4/IIIb	>2.473	µM	Virus entry	Syncytial plaque-forming assay	12186891
15	Ac:acetyl	Ac-NQTKDLQQKFYEIIMDIEQNNVQGKKGIQQLQKWE-NH2	C-terminal HR2 domain of FIV gp46	CEM4/IIIb	>2.322	µM	Virus entry	Syncytial plaque-forming assay	12186891
16	Ac: acetyl	Ac-NRGLAA	Synthetic	NA	>1000	µM	Protease inhibition	Enzyme inhibition assay	8783807
17	Ac:acetyl	Ac-QTKDLQQKFYEIIMDIEQNNVQGKKGIQQLQKWED-NH2	C-terminal HR2 domain of FIV gp47	CEM4/IIIb	>2.321	µM	Virus entry	Syncytial plaque-forming assay	12186891
18	Ac: acetyl	Ac-QVSQNY	Synthetic	NA	100	µM	Protease inhibition	Enzyme inhibition assay	8783807
19	Ac: acetyl	Ac-SYEL	Synthetic	NA	55	µM	Protease inhibition	Enzyme inhibition assay	8783807
20	Ac: acetyl	Ac-TVSFNF	Synthetic	NA	140	µM	Protease inhibition	Enzyme inhibition assay	8783807
21	Ac: acetyl	Ac-TVSYELN	Synthetic	NA	100	µM	Protease inhibition	Enzyme inhibition assay	8783807
22	Ac: acetyl	Ac-YDL	Synthetic	NA	9	µM	Protease inhibition	Enzyme inhibition assay	8783807
23	Ac: acetyl	Ac-YEL	Synthetic	NA	34	µM	Protease inhibition	Enzyme inhibition assay	8783807
24	Ac: acetyl	Ac-YEW	Synthetic	NA	21	µM	Protease inhibition	Enzyme inhibition assay	8783807
25	Amino group	AIGSILGALAKGLPTLISWIKNR-NH₂	Rana tagoi	T cells	0	NA	Fusion inhibitor	GFP expression	16140737
26	Bio: biotinyl	Bio-CapTVSYEL	Synthetic	NA	3	µM	Protease inhibition	Enzyme inhibition assay	8783807
27	Bio: biotinyl	Bio-TVSYEL	Synthetic	NA	5	µM	Protease inhibition	Enzyme inhibition assay	8783807
28	Bio: biotinyl	Bio-YEL	Synthetic	NA	8	µM	Protease inhibition	Enzyme inhibition assay	8783807
29	Amino group	FFGKVLKLIRKIF-NH2	D76 (frog)	CEM-SS	0.63	µM	Multi-function	Formazan assay	20086159
30	Amino group	FISAIASMLGKFL-NH₂	Rana catesbeiana	T cells	Low	NA	Fusion inhibitor	GFP expression	16140737
31	Amino group	GFGKAFHSVSNFAKKHKTA-NH2	Styelin A (tunicate)	CEM-SS	>48.5	µM	Multi-function	Formazan assay	20086159
32	Amino group	GFKDLLKGAAKALVKTVLF-NH2	Ascaphin-8 (frog)	CEM-SS	1.2	µM	Multi-function	Formazan assay	20086159
33	(I): D-Isoleucine, (L): D-Leucine	GFKRIVQR(I)KDF(L)RNLV	Cathelicidin	CEM-SS	47.5	µM	Multi-function	Cytopathic effect	18591279
34	(I): D-Isoleucine	GFKRIVQR(I)KDFLRNLV	Cathelicidin	CEM-SS	47.5	µM	Multi-function	Cytopathic effect	18591279
35	Amino group	GFKRIVQRIKDFLRNLV-NH2	NA	CEM-SS	0.76	µM	Multi-function	Formazan assay	20086159
36	Amino group	GFLSILKKVLPKVMAHMK-NH2	Melectin (insect)	CEM-SS	4.34	µM	Multi-function	Formazan assay	20086159
37	Amino group	GFNEIVQDIEDFLQNLV-NH2	NA	CEM-SS	>25.1	µM	Multi-function	Formazan assay	20086159
38	X: phenylglycine.	GIKEXKRIVQRIKDFLRNLV	Cathelicidin	CEM-SS	>40.6	µM	Multi-function	Cytopathic effect	18591279
39	Amino group	GIWDTIKSMGKVFAGKILQNL-NH2	Brevinin-2 related (frog)	CEM-SS	1.65	µM	Multi-function	Formazan assay	20086159
40	Amino group	GLADFLNKAVGKVVDFVKS-NH2	Desertcolin 1 (frog)	CEM-SS	>49.9	µM	Multi-function	Formazan assay	20086159
41	Amino group	GLFGVLAKVAAHVVPAIAEHF-NH₂	Litoria genimaculata	T cells	80	%	Fusion inhibitor	GFP expression	16140737
42	Amino group	GLFGVLGSIAKHVLPHVVPVIAEKL-NH₂	Litoria chloris	T cells	100	%	Fusion inhibitor	GFP expression	16140737
43	Amino group	GLLGLLGSVVSHVVPAIVGHF-NH2	Maculatin 1.3 (frog)	CEM-SS	4	µM	Multi-function	Formazan assay	20086159
44	Amino group	GLLSVLGSVAKHVLPHVVPVIAEHL-NH₂	Litoria caerulea	T cells	95	%	Fusion inhibitor	GFP expression	16140737
45	Amino group	GLWQKIKSAAGDLASGIVEGIKS-NH₂	Litoria caerulea	T cells	20	%	Fusion inhibitor	GFP expression	16140737
46	Amino group	GMASKAGAIAGKIAKVALKAL-NH2	PGLa (frog)	CEM-SS	>50.8	µM	Multi-function	Formazan assay	20086159
47	X: phenylglycine.	GRFKRXRKKXKKLFKKIS	Cathelicidin	CEM-SS	0.68	µM	Multi-function	Cytopathic effect	18591279
48	Fluorescein isothiocyanate	GTKWLTEWIPLTAEAEC-FITC	Pep-A/Synthetic	HeLa	2.7 ± 0.7	(Ki) µM	Reverse Transcriptase	RT-Polymerase Assay	18952602
49	Amino group	GVIDAAKKWNVLKNLF-NH₂	Uperoleia mjobergii	T cells	20	%	Fusion inhibitor	GFP expression	16140737
50	Amino group	GWFDVVKHIAKRF-NH2	D70 (frog)	CEM-SS	2.99	µM	Multi-function	Formazan assay	20086159
51	Ibu: isobutyroyl	Ibu-TVSFNF	Synthetic	NA	<62	µM	Protease inhibition	Enzyme inhibition assay	8783807
52	Ibu: isobutyroyl	Ibu-TVSYEL	Synthetic	NA	6	µM	Protease inhibition	Enzyme inhibition assay	8783807
53	Ibu: isobutyroyl	Ibu-TVSYELNH	Synthetic	NA	175	µM	Protease inhibition	Enzyme inhibition assay	8783807
54	Amino group	IKWKKLLRAAKRIL-NH2	D74 (insect)	CEM-SS	>57.6	µM	Multi-function	Formazan assay	20086159
55	(b): benzyl	KEEIC(b)E(b)VEDQT(b)Y	V1J1 region of the CD4 molecule	CEM-SS	>500	µM	Fusion inhibitor	Cytopathic effect	2078014
56	p: D-proline	LEAIPCSIPpCFLFNKPFVF	Human hemofiltrate	P4-CCR5	0.20±0.04	µM	Virus entry	ELISA	17448989
57	p: D-proline	LEAIPCSIPpCFLFNKPFVF	Human hemofiltrate	P4-CCR5	High	NA	Virus entry	ELISA	17448989
58	p: D-proline	LEAIPCSIPpCVAFNKPFVF	Human hemofiltrate	P4-CCR5	0.94±0.54	µM	Virus entry	ELISA	17448989
59	p: D-proline	LEAIPCSIPpCVFFNKPFVF	Human hemofiltrate	P4-CCR5	0.33±0.07	µM	Virus entry	ELISA	17448989
60	p: D-proline, Tic:tetrahydro-isoquinoline-3-carboxylic acid	LEAIPMGIPpEV(L-Tic)FNKPFVF	Human hemofiltrate	P4-CCR5	0.28±0.08	µM	Virus entry	ELISA	17448989
61	p: D-proline	LEAIPMGIPpEVLFNKPFVF	Human hemofiltrate	P4-CCR5	High	NA	Virus entry	ELISA	17448989
62	Am: amide	LEAIPMSIPPEVKFNKPFVF-Am	Human hemofiltrate	P4-CCR5	>100	µM	Virus entry	ELISA	17448989
63	p: D-proline, Tic:tetrahydro-isoquinoline-3-carboxylic acid	LEKIPMSIPpEV(L-Tic)FNKPFVF	Human hemofiltrate	P4-CCR5	0.41±0.13	µM	Virus entry	ELISA	17448989
64	(Set): S-ethyl	LQITC(SEt)W	Synthetic	NA	12	µM	Protease inhibition	Enzyme inhibition assay	8783807
65	(w):D-Trp	LQITL(w)	Synthetic	NA	140	µM	Protease inhibition	Enzyme inhibition assay	8783807
66	Amino group	Natural mixture of peptides	Rana catesbeiana	T cells	25	%	Fusion inhibitor	GFP expression	16140737
67	Pam: palmitoyl	Pam-TVSFNF	Synthetic	NA	15	µM	Protease inhibition	Enzyme inhibition assay	8783807
68	Pam: palmitoyl	Pam-TVSYEL	Synthetic	NA	0.5	µM	Protease inhibition	Enzyme inhibition assay	8783807
69	Amino group	SLSRFLRFLKIVYRRAF-NH2	D98 (frog)	CEM-SS	0.83	µM	Multi-function	Formazan assay	20086159
70	(b): benzyl, (Y): D-tyrosine	T(b)(Y)IC(b)EVE(b)DQKEE	V1J1 region of the CD4 molecule	CEM-SS	125	µM	Fusion inhibitor	Cytopathic effect	2078014
71	(b): benzyl, (Y): D-tyrosine	T(b)(Y)YIC(b)E(b)VEDQKEE	V1J1 region of the CD4 molecule	CEM-SS	250	µM	Fusion inhibitor	Cytopathic effect	2078014
72	(b): benzyl	T(b)EVE(b)lKC(b)QEDVE	V1J1 region of the CD4 molecule	CEM-SS	>500	µM	Fusion inhibitor	Cytopathic effect	2078014
73	(b): benzyl	T(b)EYE(b)lKC(b)QE(b)DVE	V1J1 region of the CD4 molecule	CEM-SS	125-250	µM	Fusion inhibitor	Cytopathic effect	2078014
74	(b): benzyl	T(b)Y(b)IC(b)EVEDQKEE	V1J1 region of the CD4 molecule	CEM-SS	63	µM	Fusion inhibitor	Cytopathic effect	2078014
75	(b): benzyl	T(b)YIC(b)E(b)KVQDE£E	V1J1 region of the CD4 molecule	CEM-SS	63	µM	Fusion inhibitor	Cytopathic effect	2078014
76	(b): benzyl	T(b)YIC(b)E(b)KVQDE£E	V1J1 region of the CD4 molecule	CEM-SS	63-132	µM	Fusion inhibitor	Cytopathic effect	2078014
77	(b): benzyl	T(b)YIC(b)E(b)VEDQKEE	V1J1 region of the CD4 molecule	CEM-SS	63	µM	Fusion inhibitor	Cytopathic effect	2078014
78	(b): benzyl	T(b)YIC(b)EVE(b)DOKEE	V1J1 region of the CD4 molecule	CEM-SS	>500	µM	Fusion inhibitor	Cytopathic effect	2078014
79	(b): benzyl	T(b)YIC(b)EVE(b)DQ(d)KEE	V1J1 region of the CD4 molecule	CEM-SS	32	µM	Fusion inhibitor	Cytopathic effect	2078014
80	(b): benzyl (acm): acetamidomethyl	T(b)YlC(acm)E(b)VEDQKEE	V1J1 region of the CD4 molecule	CEM-SS	>500	µM	Fusion inhibitor	Cytopathic effect	2078014
81	(b): benzyl	TYIC(b)E(b)VEDQKEE	V1J1 region of the CD4 molecule	CEM-SS	125	µM	Fusion inhibitor	Cytopathic effect	2078014
82	(b): benzyl	TYIC(b)EVEDQKEE	V1J1 region of the CD4 molecule	CEM-SS	>500	µM	Fusion inhibitor	Cytopathic effect	2078014
83	(Set): S-ethyl	VSYEC(SEt)G	Synthetic	NA	120	µM	Protease inhibition	Enzyme inhibition assay	8783807
84	Cyclic	cyclo(d-Ala-d-Phe-d-Phe-Ile-Arg-Trp-d-Ala-d-Ala-d-Ala-Glu)-Lys	Synthetic	NA	5.3± 0.8	µM	Reverse transcription primer	Fluorescence anisotropy	22276994
85	Fpa: Fluorophenylalanine, Nle: Norleucine	cyclo(d-Ala-Trp-Tyr-Gln-Fpa-Nle-d-Ala-d-Ala-d-Ala-Glu)-Lys	Synthetic	NA	0.61± 0.04	µM	Reverse transcription primer	Fluorescence anisotropy	22276994
86	Phg: Phenylglycine	cyclo(d-Ala-Thr-Tyr-Tyr-Trp-Phg-d-Ala-d-Ala-d-Ala-Glu)-Lys	Synthetic	NA	23± 3	µM	Reverse transcription primer	Fluorescence anisotropy	22276994
87	Fpa: Fluorophenylalanine	cyclo(d-Ala-Ile-Fpa-Arg-Tyr-Trp-d-Ala-d-Ala-Glu)-Lys	Synthetic	NA	0.91± 0.1	µM	Reverse transcription primer	Fluorescence anisotropy	22276994

Peptides having non-natural or modified amino acids