SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
SM3466 |
AACCCACCACAGCUAGAACUU AAGUUCUAGCUGUGGUGGGUU |
0 2-O-Methyl |
0 3,4,5,7,9,11,12,13,14,15,16,17,18,20,21 |
0 Sugar |
15 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3482 |
AACCCACCACAGCUAGAACUU AAGUUCUAGCUGUGGUGGGUU |
0 2-Deoxy-2-Fluoro |
0 4,5,7,13,16,20,21 |
0 Sugar |
14 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3486 |
UUAAUGCUAAUCGUGAUAGGGGUU CCCCUAUCACGAUUAGCAUUAAUA |
0 2-Deoxy-2-Fluoro |
0 5,6,7,9,12,13,14,15,18,19,20,21,22,23,24 |
0 Sugar |
15 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3513 |
GAAACUGGUACUUUCCCCCTT GGGGGAAAGUACCAGUUUCTT |
0 2-Deoxy-2-Fluoro |
0 10,16,17,18 |
0 Sugar |
26 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3524 |
GGGAAACUGAAAGGCUAUGTT CAUAGCCUUUCAGUUUCCCTT |
0 2-Deoxy-2-Fluoro |
0 1,3,6,7,8,9,10,11,14,15,16,17,18,19 |
0 Sugar |
6 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3537 |
ACCUUUCCACUUCUAAGCCTT GGCUUAGAAGUGGAAAGGUTT |
0 2-O-Methyl |
0 4,5,11,19 |
0 Sugar |
80 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3544 |
GAAGAUAGGAAGGGGCUUCTT GAAGCCCCUUCCUAUCUUCTT |
0 2-Deoxy-2-Fluoro |
0 5,6,7,8,9,10,11,12,13,15,16,17,18,19 |
0 Sugar |
5 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3568 |
GAUAGGAAGGGGCUUCAGCTT GCUGAAGCCCCUUCCUAUCTT |
0 2-O-Methyl |
0 2,3,8,9,10,11,12,13,14,15,16,18,19 |
0 Sugar |
12 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3606 |
ACCGACGAUUCUUCUACUCTT GAGUAGAAGAAUCGUCGGUTT |
0 2-O-Methyl |
0 4 |
0 Sugar |
68 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3618 |
CGAGUGUCUAACGGGAGCCTT GGCUCCCGUUAGACACUCGTT |
0 2-O-Methyl |
0 10 |
0 Sugar |
68 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3682 |
AAGGAACGGGGACACUUACTT GUAAGUGUCCCCGUUCCUUTT |
0 2-O-Methyl |
0 2 |
0 Sugar |
38 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3726 |
GCUGAGGAAAGGGACAUCUTT AGAUGUCCCUUUCCUCAGCTT |
0 2-O-Methyl |
0 3,4 |
0 Sugar |
78 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3766 |
CGGGUACGAGCCGGAACCUTT AGGUUCCGGCUCGUACCCGTT |
0 2-Deoxy-2-Fluoro |
0 14 |
0 Sugar |
69 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3794 |
AGAUGUUCUCGUAAGGACGTT CGUCCUUACGAGAACAUCUTT |
0 2-O-Methyl |
0 7 |
0 Sugar |
69 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3798 |
UCUCGUAAGGACGAAACGATT UCGUUUCGUCCUUACGAGATT |
0 2-O-Methyl |
0 13 |
0 Sugar |
55 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3806 |
CCUCGGAGAGUUCUACUCUTT AGAGUAGAACUCUCCGAGGTT |
0 2-O-Methyl |
0 5 |
0 Sugar |
85 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3822 |
GGUAGGGUUGAAGAGACUUTT AAGUCUCUUCAACCCUACCTT |
0 2-O-Methyl |
0 16 |
0 Sugar |
95 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3830 |
GGCCUUUCUCUCUAGAUAUTT AUAUCUAGAGAGAAAGGCCTT |
0 2-O-Methyl |
0 2,6 |
0 Sugar |
90 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3834 |
GCCUCUCUAUCCUUAGCUUTT AAGCUAAGGAUAGAGAGGCTT |
0 2-Deoxy-2-Fluoro |
0 5,11 |
0 Sugar |
48 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3858 |
ACAUAGAGGAAGACGCGGATT UCCGCGUCUUCCUCUAUGUTT |
0 2-Deoxy-2-Fluoro |
0 15 |
0 Sugar |
89 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3878 |
CCUCCCCAUCCCCUUUUAATT UUAAAAGGGGAUGGGGAGGTT |
0 2-O-Methyl |
0 3 |
0 Sugar |
80 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3886 |
GGGAGGUCUUAGAAAACACTT GUGUUUUCUAAGACCUCCCTT |
0 2-O-Methyl |
0 9 |
0 Sugar |
82 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3906 |
GCUUUAAGGAACUGGAAGGTT CCUUCCAGUUCCUUAAAGCTT |
0 2-O-Methyl |
0 14 |
0 Sugar |
37 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3918 |
GAGGAUGGAUUCGACUUAGTT CUAAGUCGAAUCCAUCCUCTT |
0 2-O-Methyl |
0 2 |
0 Sugar |
94 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3934 |
GUUCACGUCCUACCCCUUUTT AAAGGGGUAGGACGUGAACTT |
0 2-Deoxy-2-Fluoro |
0 8 |
0 Sugar |
69 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |