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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 0 are 634
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM0045
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    0
    2-O-Methyl
    0
    2
    0
    Sugar
    76 percent target mRNA inhibition
    19282453
    SM0091
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    0
    2-O-Methyl* 2-Aminoethyl
    0
    1 * 21
    0
    Sugar
    80.3 percent target mRNA inhibition
    19282453
    SM0136
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    0
    2-O-Methyl* 2-Cyanoethyl
    0
    1 * 18
    0
    Sugar
    50.9 percent target mRNA inhibition
    19282453
    SM0181
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    0
    Altritol nucleic acid
    0
    1,2
    0
    Sugar
    59.4 percent target mRNA inhibition
    19282453
    SM0226
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    0
    Altritol nucleic acid
    0
    20,21
    0
    Sugar
    88.5 percent target mRNA inhibition
    19282453
    SM0271
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    0
    Altritol nucleic acid
    0
    5,8,11,14,17,20
    0
    Sugar
    0 percent target mRNA inhibition
    19282453
    SM0316
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    0
    Altritol nucleic acid
    0
    3,6,14,18,20,21
    0
    Sugar
    75.4 percent target mRNA inhibition
    19282453
    SM0361
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGT
    0
    Hexitol nucleic acid* 2-Deoxy
    0
    18,19,20 * 21
    0
    Sugar
    81.1 percent target mRNA inhibition
    19282453
    SM0406
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGT
    0
    Hexitol nucleic acid* 2-Deoxy
    0
    2,18,19,20 * 21
    0
    Sugar
    79.3 percent target mRNA inhibition
    19282453
    SM0451
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGT
    0
    Hexitol nucleic acid* 2-Deoxy
    0
    3,18,19,20 * 21
    0
    Sugar
    79.7 percent target mRNA inhibition
    19282453
    SM0496
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGT
    0
    Hexitol nucleic acid* 2-Deoxy
    0
    2,9,18,19,20 * 21
    0
    Sugar
    37.4 percent target mRNA inhibition
    19282453
    SM0541
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGT
    0
    2-Aminoethoxymethyl* 2-Deoxy
    0
    18,19 * 21
    0
    Sugar
    40.6 percent target mRNA inhibition
    19282453
    SM0586
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGT
    0
    2-Aminopropoxymethyl* 2-Deoxy
    0
    18,19 * 21
    0
    Sugar
    13.4 percent target mRNA inhibition
    19282453
    SM0631
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    0
    2-Fluoro* 2-O-Methyl
    0
    1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20
    0
    Sugar
    73.8 percent target mRNA inhibition
    19282453
    SM0676
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    0
    2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid
    0
    3,18
    0
    Sugar
    36.8 percent target mRNA inhibition
    19282453
    SM0721
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    0
    2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid
    0
    4,18
    0
    Sugar
    30.6 percent target mRNA inhibition
    19282453
    SM0766
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    0
    2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid
    0
    3,4,18
    0
    Sugar
    90.2 percent target mRNA inhibition
    19282453
    SM0811
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    0
    2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid
    0
    3,18
    0
    Sugar
    81.7 percent target mRNA inhibition
    19282453
    SM0856
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    0
    2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid
    0
    4,18
    0
    Sugar
    80.6 percent target mRNA inhibition
    19282453
    SM0901
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    0
    2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid
    0
    3,4,18
    0
    Sugar
    88 percent target mRNA inhibition
    19282453
    SM0946
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    0
    2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid
    0
    3,18
    0
    Sugar
    72.2 percent target mRNA inhibition
    19282453
    SM0991
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    0
    2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid
    0
    4,18
    0
    Sugar
    69.4 percent target mRNA inhibition
    19282453
    SM1036
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    0
    2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid
    0
    3,4,18
    0
    Sugar
    68.1 percent target mRNA inhibition
    19282453
    SM1081
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    0
    2-Aminoethyl
    0
    20,21
    0
    Sugar
    86.5 percent target mRNA inhibition
    19282453
    SM1126
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    0
    2-Aminopropyl
    0
    1
    0
    Sugar
    55.1 percent target mRNA inhibition
    19282453