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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 0 are 558
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM1398
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    0
    18
    0
    Sugar
    0
    89.9 percent target mRNA inhibition
    19282453
    SM1399
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Guanidinoethyl
    0
    18
    0
    Sugar
    0
    88.1 percent target mRNA inhibition
    19282453
    SM1400
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    Hexitol nucleic acid
    0
    2,8,14,17
    0
    Sugar
    0
    84.9 percent target mRNA inhibition
    19282453
    SM1401
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGC
    Hexitol nucleic acid
    0
    5,8,14,17,22
    0
    Sugar
    0
    59.9 percent target mRNA inhibition
    19282453
    SM1402
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGC
    Altritol nucleic acid* 2-Deoxy
    0
    1,2 * 22
    0
    Sugar
    0
    89.2 percent target mRNA inhibition
    19282453
    SM1403
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGC
    Altritol nucleic acid* 2-Deoxy
    0
    18,19 * 22
    0
    Sugar
    0
    89.7 percent target mRNA inhibition
    19282453
    SM1404
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGC
    Altritol nucleic acid* 2-Deoxy
    0
    5,8,11,14,17 * 22
    0
    Sugar
    0
    69.4 percent target mRNA inhibition
    19282453
    SM1405
    GACGUAAACGGCCACAAGUUCU
    ACUUGUGGCCGUUUACGUCGC
    Altritol nucleic acid
    0
    20,21
    0
    Sugar
    0
    84.4 percent target mRNA inhibition
    19282453
    SM1406
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    Hexitol nucleic acid
    0
    19,20
    0
    Sugar
    0
    88.7 percent target mRNA inhibition
    19282453
    SM1407
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGC
    Hexitol nucleic acid* 2-Deoxy
    0
    1,2,3,18,19,20 * 21
    0
    Sugar
    0
    89 percent target mRNA inhibition
    19282453
    SM1408
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGC
    Hexitol nucleic acid* 2-Deoxy
    0
    5,8,11,14 * 21
    0
    Sugar
    0
    81.2 percent target mRNA inhibition
    19282453
    SM1409
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGC
    Hexitol nucleic acid* 2-Deoxy
    0
    5,8,11,14,19,20 * 21
    0
    Sugar
    0
    87.4 percent target mRNA inhibition
    19282453
    SM1410
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethoxymethyl* 2-Deoxy
    0
    19,20 * 21
    0
    Sugar
    0
    89.2 percent target mRNA inhibition
    19282453
    SM1411
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethoxymethyl* 2-Deoxy
    0
    3,5,9,19,20 * 21
    0
    Sugar
    0
    89.3 percent target mRNA inhibition
    19282453
    SM1412
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGC
    2-Aminopropoxymethyl* 2-Deoxy
    0
    19,20 * 21
    0
    Sugar
    0
    88.2 percent target mRNA inhibition
    19282453
    SM1413
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGC
    2-Aminopropoxymethyl* 2-Deoxy
    0
    3,5,9,19,20 * 21
    0
    Sugar
    0
    83.1 percent target mRNA inhibition
    19282453
    SM1414
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    Oxetane-Locked nucleic acid
    0
    16,18
    0
    Sugar
    0
    89.5 percent target mRNA inhibition
    19282453
    SM1415
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    Oxetane-Locked nucleic acid
    0
    2,4
    0
    Sugar
    0
    87.3 percent target mRNA inhibition
    19282453
    SM1416
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Fluoro* 2-O-Methyl
    0
    1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20
    0
    Sugar
    0
    87.3 percent target mRNA inhibition
    19282453
    SM1417
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    0
    20
    0
    Sugar
    0
    88.8 percent target mRNA inhibition
    19282453
    SM1418
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    0
    19
    0
    Sugar
    0
    89.2 percent target mRNA inhibition
    19282453
    SM1419
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    0
    5,19,20
    0
    Sugar
    0
    87.1 percent target mRNA inhibition
    19282453
    SM1420
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    0
    3,9,15,20,21
    0
    Sugar
    0
    88.1 percent target mRNA inhibition
    19282453
    SM1421
    GACGUAAACGGCCACAAGTTC
    ACUUGUGGCCGUUUACGUCGC
    4-C-Hydroxymethyl Deoxyribonucleic acid
    0
    19,20
    0
    Sugar
    0
    85.3 percent target mRNA inhibition
    19282453
    SM1422
    GACGTAAACGGCCACAAGTTC
    ACUUGUGGCCGUUUACGUCGC
    4-C-Hydroxymethyl Deoxyribonucleic acid
    0
    5,19,20
    0
    Sugar
    0
    88.6 percent target mRNA inhibition
    19282453