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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
- By modification in sense strand
- By modification position in sense strand
- By modification in antisense strand
- By modification position in antisense strand
- Reference
Total number of Results for 1,2,13,14 are 6
Results from 0 - 25
SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
SM4682 |
NNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNN |
Locked nucleic acid Locked nucleic acid |
1,2,13,14 9,10,19,20 |
Sugar Sugar |
60 percent target mRNA inhibition | EP2548962A1 |
SM4683 |
NNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNN |
Locked nucleic acid 0 |
1,2,13,14 0 |
Sugar 0 |
80 percent target mRNA inhibition | EP2548962A1 |
SM4691 |
NNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNN |
Locked nucleic acid Locked nucleic acid |
1,2,13,14 9,10,19,20 |
Sugar Sugar |
0 percent target mRNA inhibition | EP2548962A1 |
SM4692 |
NNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNN |
Locked nucleic acid 0 |
1,2,13,14 0 |
Sugar 0 |
0 percent target mRNA inhibition | EP2548962A1 |
SM4698 |
NNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNN |
2-O-Methyl 0 |
1,2,13,14 0 |
Sugar 0 |
75 percent target mRNA inhibition | EP2548962A1 |
SM4704 |
NNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNN |
2-O-Methyl 0 |
1,2,13,14 0 |
Sugar 0 |
0 percent target mRNA inhibition | EP2548962A1 |