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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 1,2,18,19 are 15
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2274
    AAGUAAGGACCAGAGACAA
    UUGUCUCUGGUCCUUACUU
    0
    4-Thioribose
    0
    1,2,18,19
    0
    Sugar
    IC-50 = 1.2 nM for target mRNA
    16509579
    SM2279
    AAGUAAGGACCAGAGACAA
    UUGUCUCUGGUCCUUACUU
    4-Thioribose
    4-Thioribose
    4,10,11,17
    1,2,18,19
    Sugar
    Sugar
    IC-50 = 1.7 nM for target mRNA
    16509579
    SM2280
    AAGUAAGGACCAGAGACAA
    UUGUCUCUGGUCCUUACUU
    4-Thioribose
    4-Thioribose
    1,2,18,19
    1,2,18,19
    Sugar
    Sugar
    IC-50 = 0.21 nM for target mRNA
    16509579
    SM2282
    AAGUAAGGACCAGAGACAA
    UUGUCUCUGGUCCUUACUU
    2-O-(2-Methoxyethyl)
    4-Thioribose
    1,2,3,17,18,19
    1,2,18,19
    Sugar
    Sugar
    IC-50 = 0.66 nM for target mRNA
    16509579
    SM4911
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    0
    4-Thioribose
    0
    1,2,18,19
    0
    Sugar
    88.8 percent target mRNA inhibition
    17924376
    SM4921
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    4-Thioribose
    1,2,18,19
    1,2,18,19
    Sugar
    Sugar
    85.3 percent target mRNA inhibition
    17924376
    SM4928
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    4-Thioribose
    1,2
    1,2,18,19
    Sugar
    Sugar
    90.4 percent target mRNA inhibition
    17924376
    SM4929
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    4-Thioribose
    1,2,3,4
    1,2,18,19
    Sugar
    Sugar
    85.4 percent target mRNA inhibition
    17924376
    SM4930
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    4-Thioribose
    1,2,3,4,16,17,18,19
    1,2,18,19
    Sugar
    Sugar
    87.7 percent target mRNA inhibition
    17924376
    SM4931
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    4-Thioribose
    1,2,3,4,5,6,14,15,16,17,18,19
    1,2,18,19
    Sugar
    Sugar
    28.6 percent target mRNA inhibition
    17924376
    SM4939
    AAACAUGCAGAAAAUGCUGTT
    CAGCAUUUUCUGCAUGUUUTT
    0
    4-Thioribose
    0
    1,2,18,19
    0
    Sugar
    42.5 percent target mRNA inhibition
    17924376
    SM4948
    AAACAUGCAGAAAAUGCUGTT
    CAGCAUUUUCUGCAUGUUUTT
    4-Thioribose
    4-Thioribose
    1,2
    1,2,18,19
    Sugar
    Sugar
    44.8 percent target mRNA inhibition
    17924376
    SM4949
    AAACAUGCAGAAAAUGCUGTT
    CAGCAUUUUCUGCAUGUUUTT
    4-Thioribose
    4-Thioribose
    1,2,3,4
    1,2,18,19
    Sugar
    Sugar
    60.2 percent target mRNA inhibition
    17924376
    SM4950
    AAACAUGCAGAAAAUGCUGTT
    CAGCAUUUUCUGCAUGUUUTT
    4-Thioribose
    4-Thioribose
    1,2,3,4,16,17,18,19
    1,2,18,19
    Sugar
    Sugar
    66.3 percent target mRNA inhibition
    17924376
    SM4954
    AAACAUGCAGAAAAUACCUTT
    CAGCAUUUUCUGCAUGUUUTT
    4-Thioribose
    4-Thioribose
    1,2,3,4,16,17,18,19
    1,2,18,19
    Sugar
    Sugar
    80.8 percent target mRNA inhibition
    17924376