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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 1,2,3 are 5
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2243
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    2-O-Methyl
    1,2,3
    1,2,3
    Sugar
    Sugar
    60 percent target mRNA inhibition
    16598842
    SM4355
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    2-O-(2-methoxyethyl)ribose
    0
    1,2,3
    0
    Sugar
    0
    67 percent target mRNA inhibition
    15974578
    SM4359
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    2-O-(2-methoxyethyl)ribose
    0
    1,2,3
    0
    Sugar
    0
    70 percent target mRNA inhibition
    15974578
    SM4363
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    2-O-(2-methoxyethyl)ribose
    Phosphorothioate
    1,2,3
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20
    Sugar
    Phosphate
    56 percent target mRNA inhibition
    15974578
    SM4367
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    2-O-(2-methoxyethyl)ribose
    Phosphorothioate
    1,2,3
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20
    Sugar
    Phosphate
    75 percent target mRNA inhibition
    15974578