Browse By
Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
- By modification in sense strand
- By modification position in sense strand
- By modification in antisense strand
- By modification position in antisense strand
- Reference
Total number of Results for 1,2,3 are 5
Results from 0 - 25
SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
SM2243 |
AAGGAGAUCAACAUUUUCATT UGAAAAUGUUGAUCUCCUUTT |
2-O-Methyl 2-O-Methyl |
1,2,3 1,2,3 |
Sugar Sugar |
60 percent target mRNA inhibition | 16598842 |
SM2271 |
AAGUAAGGACCAGAGACAAA UUUGUCUCUGGUCCUUACUU |
0 4-Thioribose |
0 1,2,3 |
0 Sugar |
IC-50 = 0.45 nM for target mRNA | 16509579 |
SM4299 |
AAGUAAGGACCAGAGACAAA UUUGUCUCUGGUCCUUACUU |
0 2-O-Methyl |
0 1,2,3 |
0 Sugar |
19 percent target mRNA inhibition | 15974578 |
SM4306 |
AAGUAAGGACCAGAGACAAA UUUGUCUCUGGUCCUUACUU |
0 2-O-Methyl |
0 1,2,3 |
0 Sugar |
52 percent target mRNA inhibition | 15974578 |
SM4777 |
AAGUAAGGACCAGAGACAAA UUUGUCUCUGGUCCUUACUU |
0 Phosphorothioate |
0 1,2,3 |
0 Phosphate-linkage |
IC-50 = 0.144 nM for target mRNA | US 8394947 B2 |