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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for 1,2,3,4,5,6,7,17,18,19,20,21,22,23 are 4
Results from 0 - 25


SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM4273	AACCUUACCCACCUCAUGUAUCU AGAUACAUGAGGUGGGUAAGGUU	Serinol nucleic acid 0	1,2,3,4,5,6,7,17,18,19,20,21,22,23 0	Sugar 0	78 percent target mRNA inhibition	25233814
SM4278	AACCUUACCCACCUCAUGUAUCU AGAUACAUGAGGUGGGUAAGGUU	Serinol nucleic acid Serinol nucleic acid	1,2,3,4,5,6,7,17,18,19,20,21,22,23 17,18,19,20,21,22,23	Sugar Sugar	20 percent target mRNA inhibition	25233814
SM4283	AACCUUACCCACCUCAUGUAUCU AGAUACAUGAGGUGGGUAAGGUU	Serinol nucleic acid 0	1,2,3,4,5,6,7,17,18,19,20,21,22,23 0	Sugar 0	0 percent target mRNA inhibition	25233814
SM4288	AACCUUACCCACCUCAUGUAUCU AGAUACAUGAGGUGGGUAAGGUU	Serinol nucleic acid Serinol nucleic acid	1,2,3,4,5,6,7,17,18,19,20,21,22,23 17,18,19,20,21,22,23	Sugar Sugar	8 percent target mRNA inhibition	25233814