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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 are 16
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2253
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    2-O-Methyl
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    18,19
    Sugar
    Sugar
    77 percent target mRNA inhibition
    16598842
    SM2254
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    Phosphorothioate
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    Sugar
    Phosphate
    76 percent target mRNA inhibition
    16598842
    SM2255
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    2-O-Methyl
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    1,7,13,14,15,16,17,18,19
    Sugar
    Sugar
    29 percent target mRNA inhibition
    16598842
    SM2256
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    2-Fluoro
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    1,7,13,14,15,16,17,18,19
    Sugar
    Sugar
    71 percent target mRNA inhibition
    16598842
    SM2985
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Deoxy
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    0
    Sugar
    0
    38 percent target mRNA inhibition
    12923253
    SM2986
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Deoxy
    2-Deoxy
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    Sugar
    Sugar
    0 percent target mRNA inhibition
    12923253
    SM2988
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-O-Methyl
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    0
    Sugar
    0
    25 percent target mRNA inhibition
    12923253
    SM2989
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-O-Methyl
    2-O-Methyl
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    Sugar
    Sugar
    0 percent target mRNA inhibition
    12923253
    SM2991
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    Phosphorothioate
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    0
    Phosphate
    0
    62 percent target mRNA inhibition
    12923253
    SM2992
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    Phosphorothioate
    Phosphorothioate
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    Phosphate
    Phosphate
    47 percent target mRNA inhibition
    12923253
    SM3103
    GCTTGAAGTCTTTATTAAA
    UUAAUUAAAGACUUCAAGCGG
    2-Deoxy-2-Fluoroarabinonucleic acid
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    0
    Sugar
    0
    IC-50 (Greater than 20 nM) for target mRNA
    17284457
    SM3106
    GCTTGAAGTCTTTATTAAA
    UUAAUUAAAGACUUCAAGCGG
    2-Deoxy-2-Fluoroarabinonucleic acid
    2-Deoxy-2-Fluoro-4-Thioarabinonucleic acid
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    13
    Sugar
    Sugar
    IC-50 (Greater than 20 nM) for target mRNA
    17284457
    SM3109
    GCTTGAAGTCTTTATTAAA
    UUAAUUAAAGACTUCAAGCGG
    2-Deoxy-2-Fluoroarabinonucleic acid
    2-Deoxy-2-Fluoroarabinonucleic acid
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    13
    Sugar
    Sugar
    IC-50 (Greater than 20 nM) for target mRNA
    17284457
    SM3393
    TCTCTGCGGTGGTTGGCAT
    AGAGACGCCACCAACCGUA
    2-O-Methyl
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    0
    Sugar
    0
    NA
    17409398
    SM3397
    CCACCACAGCUAGAACUUA
    UAAGUUCUAGCUGUGGUGG
    2-O-Methyl
    2-O-Methyl
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    Sugar
    Sugar
    NA
    16625242
    SM4860
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    0
    Sugar
    0
    60.3 percent target mRNA inhibition
    15919084