SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
SM3467 |
AACCCACCACAGCUAGAACUU AAGUUCUAGCUGUGGUGGGUU |
2-Deoxy-2-Fluoro 0 |
1,2,6,9,11,14,15,17,18,20,21 0 |
Sugar 0 |
37 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3471 |
AACCCACCACAGCUAGAACUU AAGUUCUAGCUGUGGUGGGUU |
2-O-Methyl 2-O-Methyl |
1,2,6,9,11,14,15,17,18,20,21 7,8 |
Sugar Sugar |
44 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3472 |
AACCCACCACAGCUAGAACUU AAGUUCUAGCUGUGGUGGGUU |
2-O-Methyl 2-O-Methyl |
1,2,6,9,11,14,15,17,18,20,21 1,2,4,5,7,8,11,13,16,20,21 |
Sugar Sugar |
7 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3476 |
AACCCACCACAGCUAGAACUU AAGUUCUAGCUGUGGUGGGUU |
2-O-Methyl 0 |
1,2,6,9,11,14,15,17,18,20,21 0 |
Sugar 0 |
51 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3480 |
AACCCACCACAGCUAGAACUU AAGUUCUAGCUGUGGUGGGUU |
2-Deoxy-2-Fluoro 0 |
1,2,6,9,11,14,15,17,18,20,21 0 |
Sugar 0 |
54 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |