SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
SM2248 |
AAGGAGAUCAACAUUUUCATT UGAAAAUGUUGAUCUCCUUTT |
2-O-Methyl 2-O-Methyl |
1,3,5,7,9,11,13,15,17,19 1,3,5,7,9,11,13,15,17,19 |
Sugar Sugar |
75 percent target mRNA inhibition | 16598842 |
SM2249 |
AAGGAGAUCAACAUUUUCATT UGAAAAUGUUGAUCUCCUUTT |
2-O-Methyl 2-O-Methyl |
1,3,5,7,9,11,13,15,17,19 2,4,6,8,10,12,14,16,18, |
Sugar Sugar |
65 percent target mRNA inhibition | 16598842 |
SM2536 |
UCUUGAUGUACUCCCCUCG CGAGGGGAGUACAUCAAGA |
2-O-Methyl 2-O-Methyl |
1,3,5,7,9,11,13,15,17,19 1,3,5,7,9,11,13,15,17,19 |
Sugar Sugar |
NA | 12771196 |
SM2538 |
UCUUGAUGUACUCCCCUCG CGAGGGGAGUACAUCAAGA |
2-O-Methyl 2-O-Methyl |
1,3,5,7,9,11,13,15,17,19 1,3,5,7,9,11,13,15,17,19 |
Sugar Sugar |
NA | 12771196 |
SM2542 |
AAUUCCAGUGGUUCAUUCC GGAAUGAACCACUGGAAUU |
2-O-Methyl 2-O-Methyl |
1,3,5,7,9,11,13,15,17,19 2,4,6,8,10,12,14,16,18 |
Sugar Sugar |
NA | 12771196 |
SM2543 |
AAUUCCAGUGGUUCAUUCC GGAAUGAACCACUGGAAUU |
2-O-Methyl 2-O-Methyl |
1,3,5,7,9,11,13,15,17,19 1,3,5,7,9,11,13,15,17,19 |
Sugar Sugar |
NA | 12771196 |
SM3320 |
UGAGGUUUAGGAUUCGUGCTTGCACGAAUCCUAAACCUCA 0 |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
67 percent target mRNA inhibition | 19948766 |
SM3328 |
UGAGGUUUAGGAUUCGUGCTTGCACGAAUCCUAAACCUCA 0 |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
54 percent target mRNA inhibition | 19948766 |
SM3403 |
UCGAAGUAUUCCGCGUACG CGUACGCGGAAUACUUCGA |
2-O-Methyl 2-O-Methyl |
1,3,5,7,9,11,13,15,17,19 2,4,6,8,10,12,14,16,18 |
Sugar Sugar |
NA | 16625242 |
SM3580 |
GAUUCCAAACCCCACUAUCTT GAUAGUGGGGUUUGGAAUCTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
54 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3584 |
GAUACUUCUGGUUCCCUCCTT GGAGGGAACCAGAAGUAUCTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
45 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3600 |
CCGCCCGGCGGCGCCUUUATT UAAAGGCGCCGCCGGGCGGTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
49 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3604 |
ACCGACGAUUCUUCUACUCTT GAGUAGAAGAAUCGUCGGUTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
42 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3608 |
GGUAGAAUAGGUUUUCCCCTT GGGGAAAACCUAUUCUACCTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
11 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3612 |
UCCCUUCCACCGCCAUAUUTT AAUAUGGCGGUGGAAGGGATT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
11 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3616 |
CGAGUGUCUAACGGGAGCCTT GGCUCCCGUUAGACACUCGTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
25 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3620 |
GACCACGAAGAGUUAACCCTT GGGUUAACUCUUCGUGGUCTT |
2-Deoxy-2-Fluoro 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
51 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3624 |
AGUUAACCCGGGACUUGGATT UCCAAGUCCCGGGUUAACUTT |
2-Deoxy-2-Fluoro 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
65 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3628 |
AUCACAAACCCCUAGAGGGTT CCCUCUAGGGGUUUGUGAUTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
9 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3632 |
AAACCCCUAGAGGGCAAGUTT ACUUGCCCUCUAGGGGUUUTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
62 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3636 |
UCCGGCUAACUCUGAGGACTT GUCCUCAGAGUUAGCCGGATT |
2-Deoxy-2-Fluoro 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
41 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3640 |
CGACGAUUCUUCUACUCAATT UUGAGUAGAAGAAUCGUCGTT |
2-Deoxy-2-Fluoro 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
56 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3644 |
UAAACUUUGGGGAAGGGAGTT CUCCCUUCCCCAAAGUUUATT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
34 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3648 |
AGCGGGGUAUGAAGAGCUUTT AAGCUCUUCAUACCCCGCUTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
75 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3652 |
CUCCCCAGUCUCUCUUAAATT UUUAAGAGAGACUGGGGAGTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
51 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |