Browse By

Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 1,4,5,8,10,11,19,20,21 are 14
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2546
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    0
    1,4,5,8,10,11,19,20,21
    0
    Sugar
    0
    45 percent target mRNA inhibition
    17511001
    SM2548
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    0
    2-Deoxy-2-Fluoro
    1,4,5,8,10,11,19,20,21
    2,3,4,5,6,7,8,11,13,14,17,18,20,21
    0
    Sugar
    55 percent target mRNA inhibition
    17511001
    SM2550
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    2-Deoxy-2-Fluoro
    1,4,5,8,10,11,19,20,21
    2,3,4,5,6,7,8,11,13,14,17,18,20,21
    Sugar
    Sugar
    40 percent target mRNA inhibition
    17511001
    SM2551
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    2-Deoxy-2-Fluoro
    1,4,5,8,10,11,19,20,21
    1,9,10,12,15,16,19
    Sugar
    Sugar
    39 percent target mRNA inhibition
    17511001
    SM2552
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    2-Deoxy-2-Fluoro
    1,4,5,8,10,11,19,20,21
    2,3,4,5,6,7,8,11,13,14,17,18,20,21
    Sugar
    Sugar
    18 percent target mRNA inhibition
    17511001
    SM2555
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    0
    1,4,5,8,10,11,19,20,21
    0
    Sugar
    0
    68 percent target mRNA inhibition
    17511001
    SM2559
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    2-Deoxy-2-Fluoro
    1,4,5,8,10,11,19,20,21
    2,3,4,5,6,7,8,11,13,14,17,18,20,21
    Sugar
    Sugar
    70 percent target mRNA inhibition
    17511001
    SM2560
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    2-Deoxy-2-Fluoro
    1,4,5,8,10,11,19,20,21
    1,9,10,12,15,16,19
    Sugar
    Sugar
    66 percent target mRNA inhibition
    17511001
    SM2564
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    0
    1,4,5,8,10,11,19,20,21
    0
    Sugar
    0
    82 percent target mRNA inhibition
    17511001
    SM2568
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    2-Deoxy-2-Fluoro
    1,4,5,8,10,11,19,20,21
    2,3,4,5,6,7,8,11,13,14,17,18,20,21
    Sugar
    Sugar
    81 percent target mRNA inhibition
    17511001
    SM2569
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    2-Deoxy-2-Fluoro
    1,4,5,8,10,11,19,20,21
    1,9,10,12,15,16,19
    Sugar
    Sugar
    80 percent target mRNA inhibition
    17511001
    SM2573
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    0
    1,4,5,8,10,11,19,20,21
    0
    Sugar
    0
    87 percent target mRNA inhibition
    17511001
    SM2577
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    2-Deoxy-2-Fluoro
    1,4,5,8,10,11,19,20,21
    2,3,4,5,6,7,8,11,13,14,17,18,20,21
    Sugar
    Sugar
    71 percent target mRNA inhibition
    17511001
    SM2578
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    2-Deoxy-2-Fluoro
    1,4,5,8,10,11,19,20,21
    1,9,10,12,15,16,19
    Sugar
    Sugar
    83 percent target mRNA inhibition
    17511001