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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 10,20,21 are 6
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM3237
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    Tricyclodeoxyribonucleic acid
    0
    10,20,21
    0
    Sugar
    0
    86 percent target mRNA inhibition
    21687522
    SM3245
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGTCGUGCUGCTT
    Tricyclodeoxyribonucleic acid
    Tricyclodeoxyribonucleic acid
    10,20,21
    11,20,21
    Sugar
    Sugar
    88 percent target mRNA inhibition
    21687522
    SM3251
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    Tricyclodeoxyribonucleic acid
    0
    10,20,21
    0
    Sugar
    0
    72 percent target mRNA inhibition
    21687522
    SM3259
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGTCGUGCUGCTT
    Tricyclodeoxyribonucleic acid
    Tricyclodeoxyribonucleic acid
    10,20,21
    11,20,21
    Sugar
    Sugar
    85 percent target mRNA inhibition
    21687522
    SM3265
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    Tricyclodeoxyribonucleic acid
    0
    10,20,21
    0
    Sugar
    0
    49 percent target mRNA inhibition
    21687522
    SM3273
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGTCGUGCUGCTT
    Tricyclodeoxyribonucleic acid
    Tricyclodeoxyribonucleic acid
    10,20,21
    11,20,21
    Sugar
    Sugar
    80 percent target mRNA inhibition
    21687522