SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
SM2655 |
CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT |
Morpholinouridine 0 |
12 0 |
Sugar 0 |
82 percent target mRNA inhibition | 19233658 |
SM2780 |
CUUACGCUGAGUACUUCGATT TCGAAGUACUCAGCGUAAGTT |
2,4-Difluorotoluene-2-Deoxyribonucleotide 0 |
12 0 |
Base 0 |
NA | 20610434 |
SM2784 |
CUUACGCUGAGUACUUCGATT TCGAAGUACUCAGCGUAAGTT |
2,4-Difluorotoluene 0 |
12 0 |
Base 0 |
NA | 20610434 |
SM2788 |
CUUACGCUGAGUACUUCGATT TCGAAGUACUCAGCGUAAGTT |
5-Nitroindole-2-Deoxyribonucleotide 0 |
12 0 |
Base 0 |
NA | 20610434 |
SM2792 |
CUUACGCUGAGUACUUCGATT TCGAAGUACUCAGCGUAAGTT |
5-Nitroindole-2-Deoxyribonucleotide 0 |
12 0 |
Base 0 |
NA | 20610434 |
SM2796 |
CUUACGCUGAGUACUUCGATT TCGAAGUACUCAGCGUAAGTT |
2-Deoxynebularine 0 |
12 0 |
Base 0 |
NA | 20610434 |
SM2800 |
CUUACGCUGAGUACUUCGATT TCGAAGUACUCAGCGUAAGTT |
Nebularine 0 |
12 0 |
Base 0 |
NA | 20610434 |
SM2804 |
CUUACGCUGAGUACUUCGATT TCGAAGUACUCAGCGUAAGTT |
2-Deoxy-2-Aminopurine-2-Deoxyribonucleotide 0 |
12 0 |
Base 0 |
NA | 20610434 |
SM2808 |
CUUACGCUGAGUACUUCGATT TCGAAGUACUCAGCGUAAGTT |
2-Aminopurineribonucleotide 0 |
12 0 |
Base 0 |
NA | 20610434 |
SM2812 |
CUUACGCUGAGUACUUCGATT TCGAAGUACUCAGCGUAAGTT |
2-Deoxyinosine 0 |
12 0 |
Base 0 |
NA | 20610434 |
SM2816 |
CUUACGCUGAGUACUUCGATT TCGAAGUACUCAGCGUAAGTT |
Inosine 0 |
12 0 |
Base 0 |
NA | 20610434 |
SM2820 |
CAUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAUGTT |
Abasic(2-hydroxymethyl-tetrahydrofuran-3-ol) 0 |
12 0 |
Base 0 |
NA | 20610434 |
SM2847 |
AAGUAAGGACCAGAGACAATT UUGUCUCUGGUCCUUACUUTT |
2,4-difluorotoluene ribonucleotide 0 |
12 0 |
Base 0 |
IC-50 = 0.027 nM for target mRNA | 20610434 |
SM3280 |
GUAUUGACAGCUAUUCGAATT UUCGAAUAGCUGUCAAUACTT |
Altritol nucleic acid 0 |
12 0 |
Sugar 0 |
38 percent target mRNA inhibition | 17264131 |
SM3518 |
UUUCCCCCAGGUAACGAUUTT AAUCGUUACCUGGGGGAAATT |
2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro |
12 7 |
Sugar Sugar |
75 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3718 |
GGGGCUCUUCUACAUUCCCTT GGGAAUGUAGAAGAGCCCCTT |
2-O-Methyl 2-O-Methyl |
12 8 |
Sugar Sugar |
72 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM4010 |
GAAGGGGAAAUCUGUGGUUTT AACCACAGAUUUCCCCUUCTT |
2-O-Methyl 2-O-Methyl |
12 4 |
Sugar Sugar |
65 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM4026 |
AGCUCUUUGUCACCUCUCUTT AGAGAGGUGACAAAGAGCUTT |
2-O-Methyl 2-O-Methyl |
12 11,12 |
Sugar Sugar |
37 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM4078 |
AAACGUGACUUUGGUUCCUTT AGGAACCAAAGUCACGUUUTT |
2-O-Methyl 2-O-Methyl |
12 13 |
Sugar Sugar |
83 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |