Browse By

Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 12771196 are 41
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2493
    CGUUAGCAGAAACAAAAGGAGTT
    CUCCUUUUGUUUCUGCUAACGTT
    2-Deoxythymidine
    2-Deoxythymidine
    22,23
    22,23
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    12771196
    SM2494
    CGUGAGCACAAAGAAAAUGAGTT
    CUCAUUUUCUUUGUGCUCACGTT
    2-Deoxythymidine (Mutation)
    2-Deoxythymidine (Mutation)
    22,23 (4,9,13,18)
    22,23 (4,9,13,18)
    Sugar (Base)
    Sugar (Base)
    Low mRNA target inhibition efficacy
    12771196
    SM2499
    TTCGUUAGCAGAAACAAAAGGAG
    TTCUCCUUUUGUUUCUGCUAACG
    2-Deoxythymidine
    2-Deoxythymidine
    1,2
    1,2
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    12771196
    SM2500
    TTCGUGAGCACAAAGAAAAUGAG
    TTCUCAUUUUCUUUGUGCUCACG
    2-Deoxythymidine (Mutation)
    2-Deoxythymidine
    1,2 (6,11,15,20)
    1,2
    Sugar (Base)
    Sugar
    Low mRNA target inhibition efficacy
    12771196
    SM2501
    UGGAAUGAACCACUGGAAUUUTT
    AAAUUCCAGUGGUUCAUUCCATT
    2-Deoxythymidine
    2-Deoxythymidine
    22,23
    22,23
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    12771196
    SM2502
    UGGUAUCAAGCUCAGGAAUAUTT
    AUAUUCCUGAGCUUGAUACCATT
    2-Deoxythymidine (Mutation)
    2-Deoxythymidine
    22,23 (4,7,10,12,14,20)
    22,23
    Sugar (Base)
    Sugar
    Low mRNA target inhibition efficacy
    12771196
    SM2504
    TTUGGAAUGAACCACUGGAAUUU
    TTAAAUUCCAGUGGUUCAUUCCA
    2-Deoxythymidine
    2-Deoxythymidine
    1,2
    1,2
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    12771196
    SM2507
    CGAGGGGAGUACAUCAAGACC
    UCUUGAUGUACUCCCCUCGTT
    2-Deoxyribonucleotide
    2-Deoxyribonucleotide
    20,21
    20,21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    12771196
    SM2508
    CGAGGGGAGUACAUCAAGATT
    UCUUGAUGUACUCCCCUCGTT
    2-Deoxyribonucleotide
    2-Deoxyribonucleotide
    20,21
    20,21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    12771196
    SM2510
    GGAGGGGAGUACAUCAAGUTT
    ACUUGAUGUACUCCCCUCCTT
    2-Deoxythymidine (Mutation)
    2-Deoxythymidine (Mutation)
    20,21 (1,19)
    20,21 (1,19)
    Sugar (Base)
    Sugar (Base)
    High target mRNA inhibition efficacy
    12771196
    SM2511
    GCAGGGGAGUACAUCAACUTT
    AGUUGAUGUACUCCCCUGCTT
    2-Deoxythymidine (Mutation)
    2-Deoxythymidine (Mutation)
    20,21 (1,2,18,19)
    20,21 (1,2,18,19)
    Sugar (Base)
    Sugar (Base)
    High target mRNA inhibition efficacy
    12771196
    SM2512
    CGUUAGCAGAAACAAAAGGAGTT
    CUCCUUUUGUUUCUGCUAACGTT
    2-Deoxythymidine* 5-Amino * 3-Amino
    2-Deoxythymidine* 5-Amino * 3-Amino
    22,23 * 1* 23
    22,23 * 1* 23
    Sugar
    Sugar
    Low mRNA target inhibition efficacy
    12771196
    SM2513
    CGUUAGCAGAAACAAAAGGAGTT
    CUCCUUUUGUUUCUGCUAACGTT
    2-Deoxyribonucleotide* Inverted abasic
    2-Deoxyribonucleotide* Inverted abasic
    22,23 * 1,23
    22,23 * 1,23
    Sugar
    Sugar
    Low mRNA target inhibition efficacy
    12771196
    SM2514
    CGUUAGCAGAAACAAAAGGAGTT
    CUCCUUUUGUUUCUGCUAACGTT
    2-Deoxythymidine* 5-Amino * 3-Amino
    2-Deoxyribonucleotide* Inverted abasic
    22,23 * 1* 23
    22,23 * 23
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    12771196
    SM2515
    CGUUAGCAGAAACAAAAGGAGTT
    CUCCUUUUGUUUCUGCUAACGTT
    2-Deoxythymidine* 5-Amino * 3-Amino
    2-Deoxythymidine * 3-Amino
    22,23 * 1* 23
    22,23 * 23
    Sugar
    Phosphate; Sugar
    High target mRNA inhibition efficacy
    12771196
    SM2516
    CGUUAGCAGAAACAAAAGGAGTT
    CUCCUUUUGUUUCUGCUAACGTT
    2-Deoxythymidine* 5-Amino * 3-Amino
    2-Deoxythymidine
    22,23 * 1* 23
    22,23
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    12771196
    SM2517
    CGUUAGCAGAAACAAAAGGAGTT
    CUCCUUUUGUUUCUGCUAACG
    2-Deoxythymidine* 5-Amino * 3-Amino
    0
    22,23 * 1* 23
    0
    Sugar
    0
    High target mRNA inhibition efficacy
    12771196
    SM2518
    CUCCUUUUGUUUCUGCUAACG
    CGUUAGCAGAAACAAAGGAG
    2-O-Methyl
    2-O-Methyl
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20
    Sugar
    Sugar
    Low mRNA target inhibition efficacy
    12771196
    SM2519
    CUCCUUUUGUUUCUGCUAACG
    CGUUAGCAGAAACAAAGGAG
    2-O-Methyl
    2-O-Methyl
    3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,20
    3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    Sugar
    Sugar
    Low mRNA target inhibition efficacy
    12771196
    SM2520
    CUCCUUUUGUUUCUGCUAACG
    CGUUAGCAGAAACAAAGGAG
    2-O-Methyl
    2-O-Methyl
    5,6,7,8,9,10,11,12,13,14,15,16,17
    5,6,7,8,9,10,11,12,13,14,15,16,17
    Sugar
    Sugar
    Low mRNA target inhibition efficacy
    12771196
    SM2521
    CUCCUUUUGUUUCUGCUAACG
    CGUUAGCAGAAACAAAGGAG
    2-O-Methyl
    2-O-Methyl
    7,8,9,10,11,12,13,14,15
    7,8,9,10,11,12,13,14,15
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    12771196
    SM2522
    CUCCUUUUGUUUCUGCUAACG
    CGUUAGCAGAAACAAAGGAG
    0
    2-O-Methyl
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20
    0
    Sugar
    High target mRNA inhibition efficacy
    12771196
    SM2523
    CUCCUUUUGUUUCUGCUAACG
    CGUUAGCAGAAACAAAGGAG
    2-O-Methyl
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21
    0
    Sugar
    0
    Low mRNA target inhibition efficacy
    12771196
    SM2524
    CUCCUUUUGUUUCUGCUAACG
    CGUUAGCAGAAACAAAGGAG
    2-O-Methyl
    2-O-Methyl
    1,2,3,4,5,6,7,8,9,10,11
    1,2,3,4,5,6,7,8,9,10,11
    Sugar
    Sugar
    Low mRNA target inhibition efficacy
    12771196
    SM2525
    CUCCUUUUGUUUCUGCUAACG
    CGUUAGCAGAAACAAAGGAG
    2-O-Methyl
    2-O-Methyl
    12,13,14,15,16,17,18,19,20,21
    12,13,14,15,16,17,18,19,20
    Sugar
    Sugar
    Low mRNA target inhibition efficacy
    12771196