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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for 13,14,15,16,20,21 are 10
Results from 0 - 25


SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM3232	GCAGCACGACUUCTTCAAGTT CUUGAAGAAGUCGUGCUGCTT	Tricyclodeoxyribonucleic acid 0	13,14,15,16,20,21 0	Sugar 0	90 percent target mRNA inhibition	18776474
SM3238	GCAGCACGACUUCTTCAAGTT CUUGAAGAAGUCGUGCUGCTT	Tricyclodeoxyribonucleic acid 0	13,14,15,16,20,21 0	Sugar 0	76 percent target mRNA inhibition	21687522
SM3246	GCAGCACGACUUCTTCAAGTT CUUGAAGAAGTCGUGCUGCTT	Tricyclodeoxyribonucleic acid Tricyclodeoxyribonucleic acid	13,14,15,16,20,21 11,20,21	Sugar Sugar	89 percent target mRNA inhibition	21687522
SM3247	GCAGCACGACUUCTTCAAGTT CUUGAAGAAGUCGUGCTGCTT	Tricyclodeoxyribonucleic acid Tricyclodeoxyribonucleic acid	13,14,15,16,20,21 16,17,19,20,21	Sugar Sugar	23 percent target mRNA inhibition	21687522
SM3252	GCAGCACGACUUCTTCAAGTT CUUGAAGAAGUCGUGCUGCTT	Tricyclodeoxyribonucleic acid 0	13,14,15,16,20,21 0	Sugar 0	84 percent target mRNA inhibition	21687522
SM3260	GCAGCACGACUUCTTCAAGTT CUUGAAGAAGTCGUGCUGCTT	Tricyclodeoxyribonucleic acid Tricyclodeoxyribonucleic acid	13,14,15,16,20,21 11,20,21	Sugar Sugar	86 percent target mRNA inhibition	21687522
SM3261	GCAGCACGACUUCTTCAAGTT CUUGAAGAAGUCGUGCTGCTT	Tricyclodeoxyribonucleic acid Tricyclodeoxyribonucleic acid	13,14,15,16,20,21 16,17,19,20,21	Sugar Sugar	6 percent target mRNA inhibition	21687522
SM3266	GCAGCACGACUUCTTCAAGTT CUUGAAGAAGUCGUGCUGCTT	Tricyclodeoxyribonucleic acid 0	13,14,15,16,20,21 0	Sugar 0	67 percent target mRNA inhibition	21687522
SM3274	GCAGCACGACUUCTTCAAGTT CUUGAAGAAGTCGUGCUGCTT	Tricyclodeoxyribonucleic acid Tricyclodeoxyribonucleic acid	13,14,15,16,20,21 11,20,21	Sugar Sugar	84 percent target mRNA inhibition	21687522
SM3275	GCAGCACGACUUCTTCAAGTT CUUGAAGAAGUCGUGCTGCTT	Tricyclodeoxyribonucleic acid Tricyclodeoxyribonucleic acid	13,14,15,16,20,21 16,17,19,20,21	Sugar Sugar	4 percent target mRNA inhibition	21687522