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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 16343994 are 7
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM3373
    GUGGUAUUGUUCCUCCUAATT
    UUAGGAGGAACAAUACCACTT
    2-O-Methyl
    2-O-Methyl
    1,2,3,4,5,7,8,9,10,11
    2,3,15
    Sugar
    Sugar
    IC-50 = 1.5 nM for target mRNA
    16343994
    SM3374
    GUGGUAUUGUUCCUCCUAATT
    UUAGGAGGAACAAUACCACTT
    2-O-Methyl
    2-O-Methyl
    2,5,7,8,10,11,14,17
    12,17,18,20
    Sugar
    Sugar
    IC-50 = 1.5 nM for target mRNA
    16343994
    SM3376
    GUGAUCAGACUCAAUACGAAU
    AUUCGUAUUGAGUCUGAUCACAC
    2-O-Methyl
    2-O-Methyl
    2,5,11,15,21
    12,13,14,15,16
    Sugar
    Sugar
    IC-50 = 1.5 nM for target mRNA
    16343994
    SM3378
    GUCAUCACACUGAAUACCAAU
    AUUGGUAUUCAGUGUGAUGACAC
    2-O-Methyl
    2-O-Methyl
    2,5,11,15,21
    12,13,14,15,16
    Sugar
    Sugar
    IC-50 = 1.5 nM for target mRNA
    16343994
    SM3379
    GUCAUCACACUGAAUACCAAU
    AUUGGUAUUCAGUGUGAUGACAC
    2-O-Methyl
    2-O-Methyl
    1,12
    2,3,6,8,9,13,15,18
    Sugar
    Sugar
    IC-50 = 1.5 nM for target mRNA
    16343994
    SM3380
    GUCAUCACACUGAAUACCAAU
    AUUGGUAUUCAGUGUGAUGACAC
    2-O-Methyl
    2-O-Methyl
    3,6,8,10,17,18
    4,5,12,14,16,19
    Sugar
    Sugar
    IC-50 = 1.5 nM for target mRNA
    16343994
    SM3382
    UUGAUGUGUUUAGUCGCUAUU
    UAGCGACUAAACACAUCAAUU
    2-O-Methyl
    2-O-Methyl
    5,6,7,8,9
    11,12,13,14,15
    Sugar
    Sugar
    IC-50 = 1.5 nM for target mRNA
    16343994