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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for 17616127 are 25
Results from 0 - 25


SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM4508	GUAUUGACAGCUAUUCGAATT UUCGAAUAGCUGUCAAUACTT	2-Deoxythymidine 2-Deoxythymidine	20,21 20,21	Sugar Sugar	73 percent target mRNA inhibition	17616127
SM4509	GUAUUGACAGCUAUUCGAATT UUCGAAUAGCUGUCAAUACTT	Cyclohexenyl nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	1 * 20,21 20,21	Sugar Sugar	76 percent target mRNA inhibition	17616127
SM4510	GUAUUGACAGCUAUUCGAATT UUCGAAUAGCUGUCAAUACTT	Cyclohexenyl nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	6 * 20,21 20,21	Sugar Sugar	63 percent target mRNA inhibition	17616127
SM4511	GUAUUGACAGCUAUUCGAATT UUCGAAUAGCUGUCAAUACTT	Cyclohexenyl nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	10 * 20,21 20,21	Sugar Sugar	57 percent target mRNA inhibition	17616127
SM4512	GUAUUGACAGCUAUUCGAATT UUCGAAUAGCUGUCAAUACTT	Cyclohexenyl nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	17 * 20,21 20,21	Sugar Sugar	59 percent target mRNA inhibition	17616127
SM4513	GUAUUGACAGCUAUUCGAATT UUCGAAUAGCUGUCAAUACTT	Cyclohexenyl nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	3,7 * 20,21 20,21	Sugar Sugar	74 percent target mRNA inhibition	17616127
SM4514	GUAUUGACAGCUAUUCGAATT UUCGAAUAGCUGUCAAUACTT	Cyclohexenyl nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	18 * 20,21 20,21	Sugar Sugar	55 percent target mRNA inhibition	17616127
SM4515	GUAUUGACAGCUAUUCGAATT UUCGAAUAGCUGUCAAUACTT	Cyclohexenyl nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	1,3 * 20,21 20,21	Sugar Sugar	73 percent target mRNA inhibition	17616127
SM4516	GUAUUGACAGCUAUUCGAATT UUCGAAUAGCUGUCAAUACTT	2-Deoxythymidine Cyclohexenyl nucleic acid* 2-Deoxythymidine	20,21 12 * 20,21	Sugar Sugar	64 percent target mRNA inhibition	17616127
SM4517	GUAUUGACAGCUAUUCGAATT UUCGAAUAGCUGUCAAUACTT	2-Deoxythymidine Cyclohexenyl nucleic acid* 2-Deoxythymidine	20,21 12,18 * 20,21	Sugar Sugar	74 percent target mRNA inhibition	17616127
SM4518	GUAUUGACAGCUAUUCGAATT UUCGAAUAGCUGUCAAUACTT	2-Deoxythymidine Cyclohexenyl nucleic acid* 2-Deoxythymidine	20,21 18 * 20,21	Sugar Sugar	77 percent target mRNA inhibition	17616127
SM4519	GUAUUGACAGCUAUUCGAATT UUCGAAUAGCUGUCAAUACTT	2-Deoxythymidine Cyclohexenyl nucleic acid* 2-Deoxythymidine	20,21 12 * 20,21	Sugar Sugar	65 percent target mRNA inhibition	17616127
SM4520	GAACUCUUAGCGUAUGCAATT UUGCAUACGCUAAGAGUUCTT	Cyclohexenyl nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	18 * 20,21 20,21	Sugar Sugar	NA	17616127
SM4521	GAACUCUUAGCGUAUGCAATT UUGCAUACGCUAAGAGUUCTT	Cyclohexenyl nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	9,18 * 20,21 20,21	Sugar Sugar	NA	17616127
SM4522	GAACUCUUAGCGUAUGCAATT UUGCAUACGCUAAGAGUUCTT	2-Deoxythymidine Cyclohexenyl nucleic acid* 2-Deoxythymidine	20,21 15 * 20,21	Sugar Sugar	NA	17616127
SM4523	GAACUCUUAGCGUAUGCAATT UUGCAUACGCUAAGAGUUCTT	2-Deoxythymidine Cyclohexenyl nucleic acid* 2-Deoxythymidine	20,21 7 * 20,21	Sugar Sugar	NA	17616127
SM4524	GUAUUGACAGCUAUUCGAATT UUCGAAUAGCUGUCAAUACTT	Cyclohexenyl nucleic acid* 2-Deoxythymidine Cyclohexenyl nucleic acid* 2-Deoxythymidine	17 * 20,21 12 * 20,21	Sugar Sugar	42 percent target mRNA inhibition	17616127
SM4525	GUAUUGACAGCUAUUCGAATT UUCGAAUAGCUGUCAAUACTT	Cyclohexenyl nucleic acid* 2-Deoxythymidine Cyclohexenyl nucleic acid* 2-Deoxythymidine	17 * 20,21 12 * 20,21	Sugar Sugar	40 percent target mRNA inhibition	17616127
SM4526	GUAUUGACAGCUAUUCGAATT UUCGAAUAGCUGUCAAUACTT	Cyclohexenyl nucleic acid* 2-Deoxythymidine Cyclohexenyl nucleic acid* 2-Deoxythymidine	18 * 20,21 12 * 20,21	Sugar Sugar	39 percent target mRNA inhibition	17616127
SM4527	GUAUUGACAGCUAUUCGAATT UUCGAAUAGCUGUCAAUACTT	Cyclohexenyl nucleic acid* 2-Deoxythymidine Cyclohexenyl nucleic acid* 2-Deoxythymidine	18 * 20,21 12 * 20,21	Sugar Sugar	43 percent target mRNA inhibition	17616127
SM4528	GAACUCUUAGCGUAUGCAATT UUGCAUACGCUAAGAGUUCTT	Cyclohexenyl nucleic acid* 2-Deoxythymidine Cyclohexenyl nucleic acid* 2-Deoxythymidine	18 * 20,21 15 * 20,21	Sugar Sugar	46 percent target mRNA inhibition	17616127
SM4529	GAACUCUUAGCGUAUGCAATT UUGCAUACGCUAAGAGUUCTT	Cyclohexenyl nucleic acid* 2-Deoxythymidine Cyclohexenyl nucleic acid* 2-Deoxythymidine	18 * 20,21 15 * 20,21	Sugar Sugar	36 percent target mRNA inhibition	17616127
SM4530	GAACUCUUAGCGUAUGCAATT UUGCAUACGCUAAGAGUUCTT	Cyclohexenyl nucleic acid* 2-Deoxythymidine Cyclohexenyl nucleic acid* 2-Deoxythymidine	9,18 * 20,21 7 * 20,22	Sugar Sugar	43 percent target mRNA inhibition	17616127
SM4531	GAACUCUUAGCGUAUGCAATT UUGCAUACGCUAAGAGUUCTT	Cyclohexenyl nucleic acid* 2-Deoxythymidine Cyclohexenyl nucleic acid* 2-Deoxythymidine	9,18 * 20,21 7 * 20,22	Sugar Sugar	43 percent target mRNA inhibition	17616127
SM4532	GAACUCUUAGCGUAUGCAATT UUGCAUACGCUAAGAGUUCTT	2-Deoxythymidine 2-Deoxythymidine	20,21 20,21	Sugar Sugar	56 percent target mRNA inhibition	17616127