Browse By

Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 2,3,6,7,9,12,13,14,15,16,17,18 are 11
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2545
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    0
    2,3,6,7,9,12,13,14,15,16,17,18
    0
    Sugar
    0
    10 percent target mRNA inhibition
    17511001
    SM2549
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    2-Deoxy-2-Fluoro
    2,3,6,7,9,12,13,14,15,16,17,18
    1,9,10,12,15,16,19
    Sugar
    Sugar
    28 percent target mRNA inhibition
    17511001
    SM2554
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    0
    2,3,6,7,9,12,13,14,15,16,17,18
    0
    Sugar
    0
    51 percent target mRNA inhibition
    17511001
    SM2558
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    2-Deoxy-2-Fluoro
    2,3,6,7,9,12,13,14,15,16,17,18
    1,9,10,12,15,16,19
    Sugar
    Sugar
    60 percent target mRNA inhibition
    17511001
    SM2561
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    2-Deoxy-2-Fluoro
    2,3,6,7,9,12,13,14,15,16,17,18
    2,3,4,5,6,7,8,11,13,14,17,18,20,21
    Sugar
    Sugar
    38 percent target mRNA inhibition
    17511001
    SM2563
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    0
    2,3,6,7,9,12,13,14,15,16,17,18
    0
    Sugar
    0
    64 percent target mRNA inhibition
    17511001
    SM2567
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    2-Deoxy-2-Fluoro
    2,3,6,7,9,12,13,14,15,16,17,18
    1,9,10,12,15,16,19
    Sugar
    Sugar
    77 percent target mRNA inhibition
    17511001
    SM2570
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    2-Deoxy-2-Fluoro
    2,3,6,7,9,12,13,14,15,16,17,18
    2,3,4,5,6,7,8,11,13,14,17,18,20,21
    Sugar
    Sugar
    68 percent target mRNA inhibition
    17511001
    SM2572
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    0
    2,3,6,7,9,12,13,14,15,16,17,18
    0
    Sugar
    0
    83 percent target mRNA inhibition
    17511001
    SM2576
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    2-Deoxy-2-Fluoro
    2,3,6,7,9,12,13,14,15,16,17,18
    1,9,10,12,15,16,19
    Sugar
    Sugar
    62 percent target mRNA inhibition
    17511001
    SM2579
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    2-Deoxy-2-Fluoro
    2,3,6,7,9,12,13,14,15,16,17,18
    2,3,4,5,6,7,8,11,13,14,17,18,20,21
    Sugar
    Sugar
    69 percent target mRNA inhibition
    17511001